Protein Alignment tor and Tek

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_001099207.1
• Gene: Tek / 89804
• RGDID: 620980
• Length: 1120
• Species: Rattus norvegicus
• Alignment Length: 781
• Identity: 187/781 - (23%)
• Similarity: 308/781 - (39%)
• Gaps: 235/781 - (30%)

  Fly   139 LESNSTHNI-TALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIE 202
            ||..:.:.: ..|...|:|........:.|.|...|..|.:.     |..:|:    ...|..:.
  Rat   505 LEPRTDYELCVQLVRPGEGGEGHPGPVRRFTTASIGLPPPRG-----LSLLPK----SQTALNLT 560

  Fly   203 WKP---SAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMN 264
            |:|   |:|...|.::..:|..:.:..:.::|.    ..|....::||...:||.|..| ||...
  Rat   561 WQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVP----GNLTSVLLNNLLPREQYSVRAR-VNTKA 620

  Fly   265 RLE--SDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNY 327
            :.|  .:|:...::            .:.|| :|||:.:|.   :.:..|| ::|.    :.|.|
  Rat   621 QGEWSEELRAWTLS------------DILPP-QPENIKITN---ITDYTAL-VSWT----IVDGY 664

  Fly   328 TL----------------HIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQS---- 372
            ::                ||....|     |.|:.|.:.....|:.|     :.|.:.|::
  Rat   665 SISSIIIRYKVQGKNEDQHIDVKIK-----NATITQYQLKGLEPETT-----YHVDIFAENNIGS 719

  Fly   373 ---AGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCI-LMLCSLTFCRRNRSEVQALQMD 433
               |..:.:..|...|.     |..|.|:.:.:.....:.|| ::|..|...:..|:.||.....
  Rat   720 SNPAFSQEIRTLPAPKD-----LGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQ 779

  Fly   434 A----KDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEP----HSVLLQDVLGEGAFGLVR 490
            |    ::..|.:|      :||   ||:.|...:...:..:.|    :.:..|||:|||.||.|.
  Rat   780 AFQNVREEPAVQF------NSG---TLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVL 835

  Fly   491 RGVYKK----RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIE 551
            :...||    ...|:|.:|:..:.:|...|..|:::|..:|.||||:.::| :......:.|.||
  Rat   836 KARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLG-ACEHRGYLYLAIE 899

  Fly   552 YCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEE 616
            |...|:|.:|||
  Rat   900 YAPHGNLLDFLR----------------------------------------------------- 911

  Fly   617 SESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSK 681
                                                                             
  Rat   912 ----------------------------------------------------------------- 911

  Fly   682 QDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARN 746
                   |.|:.|....|...:|:.:    .|....||..|..||.||::|:|.:.:||||||||
  Rat   912 -------KSRVLETDPAFAIANSTAS----TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARN 965

  Fly   747 VLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYE 811
            :|:..:...|||||||||.   :.||.|. ..|:||::|:|:|||.:.|||:.|||||:||||:|
  Rat   966 ILVGENYIAKIADFGLSRG---QEVYVKK-TMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE 1026

  Fly   812 ITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGM 876
            |.:|||.||..::.::|.:.|.||:|:::|..|..|::.||..||...|..||:|:.:...|..|
  Rat  1027 IVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1091

  Fly   877 I 877
            :
  Rat  1092 L 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	111/397 (28%)
Tek	NP_001099207.1	Ig_Tie2_1	24..118	CDD:463089
		EGF_Lam	230..275	CDD:238012
		IgI_Tie2	348..439	CDD:409556
		Ig strand A	348..352	CDD:409556
		Ig strand A'	358..362	CDD:409556
		Ig strand B	365..374	CDD:409556
		Ig strand C	382..387	CDD:409556
		Ig strand C'	391..393	CDD:409556
		Ig strand D	397..401	CDD:409556
		Ig strand E	404..412	CDD:409556
		Ig strand F	420..428	CDD:409556
		Ig strand G	431..439	CDD:409556
		fn3	445..518	CDD:394996	2/12 (17%)
		fn3	542..625	CDD:394996	21/96 (22%)
		FN3	638..730	CDD:238020	22/110 (20%)
		PTKc_Tie2	812..1114	CDD:133219	115/415 (28%)