DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and Fgfr1

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_077060.1	Gene:	Fgfr1 / 79114	RGDID:	620713	Length:	822	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	248/1029 - (24%)
Similarity:	373/1029 - (36%)	Gaps:	384/1029 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LLNVTACT----QNCLEKGQ-----MDFRSCLKDCRINGTFPGALRKVQENYQMNMICRTESEIV 90
            |:..|.||    ....|:.|     ::..|.|       ..||.|        :.:.||...: |
  Rat    13 LVTATLCTARPAPTLPEQAQPWGVPVEVESLL-------VHPGDL--------LQLRCRLRDD-V 61

  Fly    91 FQIDWVQHS------------------RGTEPAPNATYIIRVDAVK-DDNKETALYLSDDNFLIL 136
            ..|:|::..                  |.:.||.:..|....::.. .|....::.:||    .|
  Rat    62 QSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSD----AL 122

  Fly   137 PGLESNSTHNITALAMHGDGSYSLIAKDQTFATL--IRGY--QPSKM-------GAVNLLRF--- 187
            |..|.:...:        |.|......|.|....  :..|  .|.||       .|...::|
  Rat   123 PSSEDDDDDD--------DSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179

  Fly   188 ---VPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDN--- 246
               .|.| .|..:....|:||......|  .|.|:|.|:.||..:.    ..|..|...|:|
  Rat   180 SSGTPSP-TLRWLKNGKEFKPDHRIGGY--KVRYATWSIIMDSVVP----SDKGNYTCIVENEYG 237

  Fly   247 -----------------------LEFDKQYHVGVRTVNIMNRLESD----LQWLP-IAVPSCL-- 281
                                   |..:|...:| ..|..|.::.||    :|||. |.|....
  Rat   238 SINHTYQLDVVERSPHRPILQAGLPANKTVALG-SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 301

  Fly   282 -DWYPYNYTLCPPHKPENLTVTQKQ----YLPNI-----------------LALNITW------- 317
             |..||:..|    |...:..|.|:    :|.|:                 |:.:..|
  Rat   302 PDNLPYDQIL----KTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 362

  Fly   318 -ARPRYLPDNYTLHIFDLFKG--------GTELNYTLDQ--NRSHFYVPKITVLGSHFEVHLVAQ 371
             .||..:.....|.|.....|        |:.:.|.:..  .:|.|:        |...||.:|:
  Rat   363 EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFH--------SQMAVHKLAK 419

  Fly   372 SAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKD 436
            |                                 :|:             |.:..|.|      |
  Rat   420 S---------------------------------IPL-------------RRQVTVSA------D 432

  Fly   437 AKASEFHLSLMDSSGLLV-----TLSANESLEVMDELEV--EPHSVLLQD------VLGEGAFGL 488
            :.||      |:|..|||     :.|....|..:.|.|:  :|...|.:|      .||||.||.
  Rat   433 SSAS------MNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQ 491

  Fly   489 V----RRGVYKKR-----QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSN 544
            |    ..|:.|.:     :||||:||.:..::|:.....|::|:|.:|||.||:.::|..|: ..
  Rat   492 VVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DG 555

  Fly   545 QMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSM 609
            .:.:::||.|.|:|:.:|:.                          .|.|
  Rat   556 PLYVIVEYASKGNLREYLQA--------------------------RRPP--------------- 579

  Fly   610 LSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKP 674
                                               |||...|            |...|:.:|..
  Rat   580 -----------------------------------GLEYCYN------------PSHNPEEQLSS 597

  Fly   675 QPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVH 739
            :                                         ||:..|.|||.|||:||..|.:|
  Rat   598 K-----------------------------------------DLVSCAYQVARGMEYLASKKCIH 621

  Fly   740 RDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWS 804
            |||||||||::.|..:|||||||:||::|.:.|:|: .:|:||:||:|.|:|..::||.||||||
  Rat   622 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT-TNGRLPVKWMAPEALFDRIYTHQSDVWS 685

  Fly   805 FGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSAL 869
            |||||:||.||||.|.|.|...:|.:||::||||.:|..||.|::.:|..||::|||.||||..|
  Rat   686 FGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQL 750

  Fly   870 KHRLGGMILATN-----DVPERLKQ-LQAATESKLKSC-DGLNSKVEQVPCEEE 916
            ...|..::..|:     |:...|.| ..:..:::..:| .|.:|.....|..||
  Rat   751 VEDLDRIVALTSNQEYLDLSMPLDQDSPSFPDTRSSTCSSGEDSVFSHEPFPEE 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	17/87 (20%)
		STYKc	475..873	CDD:214568	130/412 (32%)
		PTKc	479..873	CDD:270623	129/408 (32%)
Fgfr1	NP_077060.1	Ig1_FGFR	40..118	CDD:143174	15/93 (16%)
		IG_like	41..118	CDD:214653	15/92 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		11/53 (21%)
		I-set	160..247	CDD:254352	21/93 (23%)
		Heparin-binding	160..177		3/16 (19%)
		Ig2_FGFR	163..247	CDD:143265	19/90 (21%)
		IG_like	262..358	CDD:214653	22/100 (22%)
		Ig3_FGFR	270..359	CDD:143175	21/93 (23%)
		PTKc_FGFR1	464..765	CDD:270678	134/431 (31%)
		Pkinase_Tyr	478..754	CDD:285015	128/406 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..822		8/35 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000