Protein Alignment tor and Fgr

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_077059.2
• Gene: Fgr / 79113
• RGDID: 621319
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 734
• Identity: 162/734 - (22%)
• Similarity: 259/734 - (35%)
• Gaps: 259/734 - (35%)

  Fly   179 MGAVNLLRFVPQPDDLHHIAAEIEWK-PSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKK---- 238
            ||.|...:..|.|.:  .:..|.::: ..||...|.|.....::|:: .:|:...|.:...
  Rat     1 MGCVFCKKLEPAPKE--DVGLEGDFRSQGAEERYYPDPTQGRSSSIS-PQPISPAFLNVGNIRSV 62

  Fly   239 ----------LYRH---TVDNLEFDK--QYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWY-PYN 287
                      ||.:   |.|:|.|.|  ::|       |:|..|.| .|...::.|....| |.|
  Rat    63 SGTGVTIFVALYDYEARTGDDLTFTKGEKFH-------ILNNTEYD-WWEARSLSSGRTGYVPSN 119

  Fly   288 YTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDN-----YTLHIFDLFKGGTELNY-TLD 346
            |.     .|.:....::.|...|...:   |..:.|.|.     :.:...:..||...|:. ..|
  Rat   120 YV-----APVDSIQAEEWYFGKISRKD---AERQLLSDGNPQGAFLIRESETTKGAYSLSIRDWD 176

  Fly   347 QNR----SHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVP 407
            |||    .|:.:.|:.:.|.:.......:|         ..|.|...:.:::|    |...:..|
  Rat   177 QNRGDHIKHYKIRKLDMGGYYITTRAQFES---------VQDLVRHYMEVNDG----LCYLLTAP 228

  Fly   408 ICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEP 472
              |::|            :.|.|.: ||||                              .|::.
  Rat   229 --CMVM------------KPQTLGL-AKDA------------------------------WEIDR 248

  Fly   473 HSVLLQDVLGEGAFGLVRRGVYK-KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIV 536
            :|:.|...||.|.||.|..|.:. ..:||||.||  |......||..|.|::|.: :|..:|.:
  Rat   249 NSIALDRRLGTGCFGDVWLGTWNCSTKVAVKTLK--PGTMSPKAFLEEAQIMKLL-RHDKLVQL- 309

  Fly   537 GYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDR 601
             |:......:.::.|:...|||.:||:
  Rat   310 -YAVVSEEPIYIVTEFMCYGSLLDFLK-------------------------------------- 335

  Fly   602 IEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKD 666
                                                  |.||:.|
  Rat   336 --------------------------------------DRKGHNL-------------------- 342

  Fly   667 RPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEF 731
                                                       .:|    :|:|:|.|||.||.:
  Rat   343 -------------------------------------------MLP----NLVDMAAQVAEGMAY 360

  Fly   732 LAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVY 796
            :.:...:||||.|.|:|:......|||||||:|.:. ::.|....|: |.||||.|.|:.....:
  Rat   361 MERMNYIHRDLRAANILVGEHLICKIADFGLARLIV-DDEYNPQQGT-KFPIKWTAPEAALFGRF 423

  Fly   797 TSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPS 861
            |.:|||||||:||.|:.|.|.:|||.::..::|:.:..|:.|..|.||...::.:||..|...|.
  Rat   424 TVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPE 488

  Fly   862 HRPTFSALKHRLGGMILAT 880
            .||||..|:..|.....:|
  Rat   489 ERPTFEYLQSFLEDYFTST 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	96/394 (24%)
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..46		6/29 (21%)
		SH3	68..125	CDD:473055	19/69 (28%)
		SH2_Src_Fgr	128..228	CDD:198230	20/115 (17%)
		Protein Kinases, catalytic domain	255..502	CDD:473864	97/396 (24%)