DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and TEK

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_000450.3	Gene:	TEK / 7010	HGNCID:	11724	Length:	1124	Species:	Homo sapiens

Alignment Length:	778	Identity:	185/778 - (23%)
Similarity:	309/778 - (39%)	Gaps:	227/778 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LESNSTHNI-TALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIE 202
            ||..:.:.: ..|...|:|........:.|.|...|..|.:  .:|||   |:    ......:.
Human   507 LEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPR--GLNLL---PK----SQTTLNLT 562

  Fly   203 WK---PSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRK------KLYRHTVDNLEFDKQYHVGVR 258
            |:   ||:|.:.|.::           |...||..|::      .|....::||...:||.|..|
Human   563 WQPIFPSSEDDFYVEV-----------ERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRAR 616

  Fly   259 TVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYL 323
             ||    .::..:|..       |...:..:...|.:|||:.::...:...:    |:|.    :
Human   617 -VN----TKAQGEWSE-------DLTAWTLSDILPPQPENIKISNITHSSAV----ISWT----I 661

  Fly   324 PDNYTLHIFDL---FKGGTE--------LNYTLDQNRSHFYVPKITVLGSHFEVHLVAQ-SAGGK 376
            .|.|::....:   .:|..|        .|.|:.|.:.....|:     :.::|.:.|: :.|..
Human   662 LDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPE-----TAYQVDIFAENNIGSS 721

  Fly   377 NVSG----LTLDKVHRGVLLSEGNMVKLVLFIIVPICCI-LMLCSLTFCRRNRSEVQALQMDA-- 434
            |.:.    :||.:......|..|.|:.:.:.....:.|: ::|..|...:..|:.||.....|
Human   722 NPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQ 786

  Fly   435 --KDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEP----HSVLLQDVLGEGAFGLVRRGV 493
              ::..|.:|      :||   ||:.|..::...:..:.|    :.:..|||:|||.||.|.:..
Human   787 NVREEPAVQF------NSG---TLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKAR 842

  Fly   494 YKK----RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCS 554
            .||    ...|:|.:|:..:.:|...|..|:::|..:|.||||:.::| :......:.|.|||..
Human   843 IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLG-ACEHRGYLYLAIEYAP 906

  Fly   555 LGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESES 619
            .|:|.:|||
Human   907 HGNLLDFLR-------------------------------------------------------- 915

  Fly   620 DQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDF 684

Human   916 ----------------------------------------------------------------- 915

  Fly   685 KSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLI 749
                |.|:.|....|...:|:.:    .|....||..|..||.||::|:|.:.:||||||||:|:
Human   916 ----KSRVLETDPAFAIANSTAS----TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILV 972

  Fly   750 SVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITT 814
            ..:...|||||||||.   :.||.|. ..|:||::|:|:|||.:.|||:.|||||:||||:||.:
Human   973 GENYVAKIADFGLSRG---QEVYVKK-TMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 1033

  Fly   815 LGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI 877
            |||.||..::.::|.:.|.||:|:::|..|..|::.||..||...|..||:|:.:...|..|:
Human  1034 LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	16/70 (23%)
		STYKc	475..873	CDD:214568	112/401 (28%)
		PTKc	479..873	CDD:270623	111/397 (28%)
TEK	NP_000450.3	Ig_Tie2_1	24..118	CDD:402176
		EGF_Lam	230..275	CDD:238012
		EGF_Lam	314..>342	CDD:238012
		IgI_Tie2	348..439	CDD:409556
		Ig strand B	366..370	CDD:409556
		Ig strand C	382..386	CDD:409556
		Ig strand E	407..411	CDD:409556
		Ig strand F	421..426	CDD:409556
		Ig strand G	434..437	CDD:409556
		fn3	445..520	CDD:394996	2/12 (17%)
		fn3	544..626	CDD:394996	23/106 (22%)
		FN3	639..731	CDD:238020	18/104 (17%)
		PTKc_Tie2	816..1118	CDD:133219	115/415 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100