Protein Alignment tor and SRC

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: XP_047296363.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 562
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 151/642 - (23%)
• Similarity: 224/642 - (34%)
• Gaps: 244/642 - (38%)

  Fly   248 EFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWY-PYNYTLCPPHKPENLTVTQKQYLPNI- 310
            |.|..:..|.| :.|:|..|.| .||..::.:....| |.||.     .|.:....::.|...|
Human   126 ETDLSFKKGER-LQIVNNTEGD-WWLAHSLSTGQTGYIPSNYV-----APSDSIQAEEWYFGKIT 183

  Fly   311 ------LALNITWARPRYL-------PDNYTLHI--FDLFKGGTELNYTLDQ-NRSHFYVPKITV 359
                  |.||....|..:|       ...|.|.:  ||..||....:|.:.: :...||:...|.
Human   184 RRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQ 248

  Fly   360 LGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNR 424
            ..|..:  |||..:  |:..||    .||                           ..|.|..::
Human   249 FNSLQQ--LVAYYS--KHADGL----CHR---------------------------LTTVCPTSK 278

  Fly   425 SEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLV 489
            .:.|.|   ||||                              .|:...|:.|:..||:|.||.|
Human   279 PQTQGL---AKDA------------------------------WEIPRESLRLEVKLGQGCFGEV 310

  Fly   490 RRGVYK-KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYC 553
            ..|.:. ..:||:|.||  |......||..|.|::|.: :|..:|.:  |:......:.::.||.
Human   311 WMGTWNGTTRVAIKTLK--PGTMSPEAFLQEAQVMKKL-RHEKLVQL--YAVVSEEPIYIVTEYM 370

  Fly   554 SLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESE 618
            |.|||.:||:.|
Human   371 SKGSLLDFLKGE----------------------------------------------------- 382

  Fly   619 SDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQD 683
                                              .|.|:
Human   383 ----------------------------------TGKYL-------------------------- 387

  Fly   684 FKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVL 748
                                      |:|    .|:|:|.|:|.||.::.:...|||||.|.|:|
Human   388 --------------------------RLP----QLVDMAAQIASGMAYVERMNYVHRDLRAANIL 422

  Fly   749 ISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEIT 813
            :..:...|:|||||:| :..:|.|....|: |.||||.|.|:..:..:|.:|||||||:||.|:|
Human   423 VGENLVCKVADFGLAR-LIEDNEYTARQGA-KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELT 485

  Fly   814 TLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALK 870
            |.|.:|||.:...::|..:.:|:||..|..|.:.:..||..||...|..||||..|:
Human   486 TKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	99/393 (25%)
SRC	XP_047296363.1	SH3_Src	114..169	CDD:212941	14/49 (29%)
		SH2_Src_Src	173..273	CDD:198228	26/134 (19%)
		PTKc_Src	286..562	CDD:270656	105/437 (24%)