DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Kit

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_071600.1	Gene:	Kit / 64030	RGDID:	620568	Length:	978	Species:	Rattus norvegicus

Alignment Length:	946	Identity:	207/946 - (21%)
Similarity:	349/946 - (36%)	Gaps:	289/946 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EKGQMDFRSCLKDCRINGTFPGALRKVQENYQMNMICRTESEIVFQID--WVQHSRGTEPAPNAT 109
            :|..:..|:.:|...: .:.|.....::|.....:|| |..::...:|  |::    ..|.|.:
  Rat   198 DKFTLKVRAAIKAIPV-VSVPETSHLLKEGDTFTVIC-TIKDVSTSVDSMWIK----LNPQPQS- 255

  Fly   110 YIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQTF--ATLIR 172
                    |...|..:.:..|.|:      |...|..|::..::..|.:...| :.||  |.:..
  Rat   256 --------KAQVKRNSWHQGDFNY------ERQETLTISSARVNDSGVFMCYA-NNTFGSANVTT 305

  Fly   173 GYQPSKMGAVNLLR------FVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNS----VNMDE 227
            ..:..:.|.:|:..      ||...::: .:..|.|..|..|...:..|....||.    |..|.
  Rat   306 TLKVVEKGFINIFPVKNTTVFVTDGENV-DLVVEFEAYPKPEHQQWIYMNRTPTNRGEDYVKSDN 369

  Fly   228 PLEVQFRDRKKL----------YRHTVDN------LEFDKQYHVGVRTVNIMNRLESDLQWLPIA 276
            ...:::.:..:|          |...|.|      :.||...:.....:.....:...||.:...
  Rat   370 QSNIRYVNELRLTRLKGTEGGTYTFLVSNSDVSASVTFDVYVNTKPEILTYDRLMNGRLQCVAAG 434

  Fly   277 VPS-CLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTE 340
            .|. .:|||                                                  |..|.|
  Rat   435 FPEPTIDWY--------------------------------------------------FCTGAE 449

  Fly   341 LNYTLD--------QNRSHFYVPKITVLGS--------HFEVHLVAQSAGGKN-------VSGLT 382
            ...|:.        ||.|.....|:.|..|        :..|...|.:|.||:       ..|.:
  Rat   450 QRCTVPVPPVDVQIQNASVSPFGKLVVQSSIDSSVFRHNGTVECKASNAVGKSSAFFNFAFKGNS 514

  Fly   383 LDKVHRGVLLSEGNMVKLVLFIIVP--ICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLS 445
            .:::....|.:.    .|:.|::..  :..|:|:.:..:.::...|||
  Rat   515 KEQIQPHTLFTP----LLIGFVVTAGLMGIIVMVLAYKYLQKPMYEVQ----------------- 558

  Fly   446 LMDSSGLLVTLSANESLEVMDELE------VEP-------------HSVLLQDVLGEGAFGLV-- 489
                            .:|::|:.      ::|             :.:.....||.||||.|
  Rat   559 ----------------WKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVE 607

  Fly   490 --RRGVYKK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLL 549
              ..|:.|.   ..||||:||...:..:..|...|:::|..:|.|.|||.::|..| .....:::
  Rat   608 ATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-VGGPTLVI 671

  Fly   550 IEYCSLGSLQNFLREE-----WKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSM 609
            .|||..|.|.||||.:     :..::||....|.|||                :|.:
  Rat   672 TEYCCYGDLLNFLRRKRDSFIFSKQEEQADAALYKNL----------------LHSK-------- 712

  Fly   610 LSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKP 674
                  ||..|.::             ...|.|.         |.||:..|            |.
  Rat   713 ------ESSCDSSN-------------EYMDMKP---------GVSYVVPT------------KT 737

  Fly   675 QPKKDSKQD--FKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKV 737
            ..::.::.|  .:.|....|.|:.|             :.|...|||..:.|||.||.|||....
  Rat   738 DKRRSARIDSYIERDVTPAIMEDDE-------------LALDLEDLLSFSYQVAKGMAFLASKNC 789

  Fly   738 VHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDV 802
            :||||||||:|::..|..||.||||:||:.:::.|... |:.:||:||:|.||:.:.|||.:|||
  Rat   790 IHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVK-GNARLPVKWMAPESIFNCVYTFESDV 853

  Fly   803 WSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTF 866
            ||:|:.|:|:.:||..|||.:. .|...:::::|.||..||.....|:.:|::||.:.|..||||
  Rat   854 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAAMYEVMKTCWDADPLKRPTF 918

  Fly   867 SALKHRLGGMILATNDVPERLKQLQAATESKLKSCD 902
            ..:      :.|....:.:..|.:.    |.|.:|:
  Rat   919 KQV------VQLIEKQISDSSKHIY----SNLANCN 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	15/81 (19%)
		STYKc	475..873	CDD:214568	126/412 (31%)
		PTKc	479..873	CDD:270623	126/408 (31%)
Kit	NP_071600.1	ig	216..307	CDD:278476	21/111 (19%)
		IG_like	220..309	CDD:214653	20/109 (18%)
		Ig4_SCFR	313..413	CDD:143268	19/100 (19%)
		Ig	428..503	CDD:299845	21/124 (17%)
		PKc_like	555..929	CDD:304357	133/491 (27%)
		Pkinase_Tyr	591..925	CDD:285015	126/418 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910