DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and pdgfrb

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_021336701.1	Gene:	pdgfrb / 559529	ZFINID:	ZDB-GENE-030805-2	Length:	1072	Species:	Danio rerio

Alignment Length:	1000	Identity:	237/1000 - (23%)
Similarity:	400/1000 - (40%)	Gaps:	272/1000 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WFFVGSNQGEMLLMDKISHDKTL--------LNVTAC---TQNCLE---------KGQMDFRSCL 57
            ||.    :.|.:::.|...:.|:        :|||..   |:..:|         ...:|.|:.:
Zfish   126 WFL----ENEHVMVTKTREEGTIPCLVTNPSINVTLYERDTEMAVEGSYNPSVGYSAALDDRTYI 186

  Fly    58 KDCRING-------------TFPGAL--------RKVQENYQMNMICRTES-EIVFQIDWVQHSR 100
            ....:||             ..|.||        ..:::...:|:.|.... |:|| ..|...::
Zfish   187 CKGELNGEEKESDLFYVFSILAPEALDPYINASKTVLKQGETLNVNCTVHGVELVF-FSWDFPNK 250

  Fly   101 ---GTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIA 162
               |.||                       |:|    :|..:...|..|||.:::...|.|
Zfish   251 DMGGIEP-----------------------LTD----VLSSMSMRSCLNITDVSLDRSGQY---- 284

  Fly   163 KDQTFATLIRGYQPSKMGA-VNL-------LRFVPQPDDLHHIAAE----IEWKPSAESNCYFDM 215
                ...:..|.|..:..| :|:       :...|..|  .:|:|:    :|.|...|
Zfish   285 ----VCHVHEGVQDQRASASINITVLEKGFVSLTPPLD--RNISAQLGENVELKVEIE------- 336

  Fly   216 VSYSTNSV------------NMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLES 268
             :|...:|            :|.|..|.:|.....|.|..:..:..   |.|.|:..:.:..:..
Zfish   337 -AYPKPTVQWRKDGAVIRGHSMREEHETRFVSTLTLVRTRLQQMGL---YKVTVQNEDALKEMIF 397

  Fly   269 DLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNI------------------ 315
            ||:   :.||      |....|...|.||      |::....:|..:
Zfish   398 DLE---VKVP------PQITELSDHHLPE------KKHAVTCVAEGVPKPSIQWFSCDSMTRCSN 447

  Fly   316 ---TWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRS-HFYVPKITVLGSH-FEVHLVAQSAGG 375
               .|:.....|::.|:          :.|.|.:..|. |..:.::|::... ..:...|.:..|
Zfish   448 RSAVWSPLVEDPESVTI----------QTNVTYNSTRKIHQVLSQVTLVRPQLLTIRCEASNERG 502

  Fly   376 KNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKAS 440
            .....:   ::....|.|:..::..||.::|.:...:::....:.::.|.|::...:::
Zfish   503 ARARDI---RLVNSTLFSQVAVLAAVLALVVIVIISIIILIAVWRKKPRYEIRWKVIES------ 558

  Fly   441 EFHLSLMDSSGLLVTLSANESLEVMDEL--------EVEPHSVLLQDVLGEGAFG-LVRRGVY-- 494
                         |:|..:|.:.| |.:        |:...|::|...||.|||| :|....|
Zfish   559 -------------VSLDGHEYIYV-DPIHLPYDLAWEMPRDSLVLGRTLGSGAFGRVVEATAYGL 609

  Fly   495 ----KKRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSL 555
                ...:||||:||......:..|...|::::..:|.|.|||.::|..|: ...:.|:.|||..
Zfish   610 GISQSATKVAVKMLKSTARRSETQALMSELKIMSHLGPHINIVNLLGACTK-QGPLYLVTEYCRY 673

  Fly   556 GSLQNFL-REEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESES 619
            |.|.::| |.:..|.|                    |...:|.|.:..:..|:|      :..:.
Zfish   674 GDLVDYLHRNKHSFLQ--------------------NFADKNHIANGTQICNDS------DSGKE 712

  Fly   620 DQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIP--KTAEAPKDRPKRKLKPQP-KKDSK 681
            ..:..|.|:             .|| ::..::....|:|  :.|:..|   ...::|.| :...:
Zfish   713 YVSFGSECD-------------GGY-MDMTKDEQTEYVPMQELADTIK---YADIQPSPYESPYQ 760

  Fly   682 QDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARN 746
            ||...:...|:..:      |..||:.   .|.|.||:..:.|||.||||||....|||||||||
Zfish   761 QDIYQEQGHRVDHS------LVISDSP---VLSYTDLVGFSYQVAQGMEFLASKNCVHRDLAARN 816

  Fly   747 VLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYE 811
            |||...:..||.||||:||:.|:|.| .|.||..||:||:|.||:.|.:||:.|||||:|:||:|
Zfish   817 VLICEGKLAKICDFGLARDIMHDNNY-ISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWE 880

  Fly   812 ITTLGGMPYPSVSPSDLL-QLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGG 875
            |.||||.|||.:..::|. ..|::|:||.:|...:.|::.:|..||......||.||.|.|.:|.
Zfish   881 IFTLGGTPYPDLPMNELFYSALKRGYRMAKPSYASDEIYEVMRKCWDEKYEKRPEFSFLVHTMGN 945

  Fly   876 MILATNDVPERLKQLQAATESKLKS 900
            |:   :|..:  |:.....:|.|||
Zfish   946 ML---SDAYK--KKYSQVNDSFLKS 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	15/77 (19%)
		STYKc	475..873	CDD:214568	137/409 (33%)
		PTKc	479..873	CDD:270623	136/405 (34%)
pdgfrb	XP_021336701.1	Ig	226..307	CDD:325142	22/116 (19%)
		Ig	309..403	CDD:325142	20/109 (18%)
		Ig_3	404..>437	CDD:316449	8/44 (18%)
		PKc_like	549..947	CDD:328722	146/471 (31%)
		Trypan_PARP	<980..1053	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010