DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Alk

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	137/554 - (24%)
Similarity:	213/554 - (38%)	Gaps:	182/554 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 MVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSS----------- 450
            |:.|.:..|.....|.||.: .:.|:.:|:.:...:..:|.:.:....::.||:
  Fly  1110 MISLAVLFICIAALIFMLYN-RYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCD 1173

  Fly   451 GLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKKRQ-------VAVKLLKDEP 508
            |:|     |..::|....:|...|:.|.:.||:||||.|...:|:.|.       ||||.|:::|
  Fly  1174 GIL-----NGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDP 1233

  Fly   509 NDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQ-MMLLIEYCSLGSLQNFLREEWKFRQEQ 572
            ..|....|..|..:: |...|||:|.::|..  |..| ..:::|..:.|.||.||||.
  Fly  1234 KREKEEDFLKEAAIM-AKFNHPNMVHLIGVC--FDRQPYYIVLELLAGGDLQKFLREN------- 1288

  Fly   573 NAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITN 637
                                  ||:
  Fly  1289 ----------------------RNT---------------------------------------- 1291

  Fly   638 AADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCL 702
                                                  |::.|....|
  Fly  1292 --------------------------------------PERPSLLTMK----------------- 1301

  Fly   703 DSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLIS---VDRSIKIADFGLSR 764
                          |||..|..||.|..::...:.:|||:||||.|:|   ..|.:||||||:||
  Fly  1302 --------------DLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSR 1352

  Fly   765 DVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLL 829
            |:|..:.||| ||...|||||:..|:....::||::||||||:||:|:.:||..|||....:.::
  Fly  1353 DIYRSDYYRK-GGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVM 1416

  Fly   830 QLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQLQAAT 894
            :|:.:|.|:..|..|...::.:|..||:..|..||||..|...|.......:.:...|..:...|
  Fly  1417 ELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPT 1481

  Fly   895 ESKLKSCDGLNSKVEQVPCEEEL------YLEPL 922
            .|:      .:..|.:.|..||.      ||.||
  Fly  1482 ASE------RDDTVIRPPNGEEFCLAVPDYLVPL 1509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495
		STYKc	475..873	CDD:214568	108/408 (26%)
		PTKc	479..873	CDD:270623	107/404 (26%)
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	111/417 (27%)
		TyrKc	1193..1460	CDD:197581	108/408 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100