DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and PDGFRB

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens

Alignment Length:	899	Identity:	222/899 - (24%)
Similarity:	343/899 - (38%)	Gaps:	271/899 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 FQIDWVQHSRGTEPAPNA------TYIIRV-DAVKDDNKETALYLSDDNFLILPGLESNSTHNIT 148
            |.:|...|.|.....|:|      ||...| ::|.|...|.|:     |..:   :||.   .:.
Human   264 FLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAI-----NITV---VESG---YVR 317

  Fly   149 ALAMHGDGSYSLIAKDQTFATLIRGYQP--------------SKMGAVNL-------LRFVPQPD 192
            .|...|...::.:.:.:|...:...|.|              |..|.:.|       .|:|   .
Human   318 LLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYV---S 379

  Fly   193 DLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGV 257
            :|..:..::     ||:. ::.|.::       .|..|||              |.|..|.:|.|
Human   380 ELTLVRVKV-----AEAG-HYTMRAF-------HEDAEVQ--------------LSFQLQINVPV 417

  Fly   258 RTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWAR--- 319
            |.:.:.   ||.                       |...|.....:.:.:|.   .||.|:.
Human   418 RVLELS---ESH-----------------------PDSGEQTVRCRGRGMPQ---PNIIWSACRD 453

  Fly   320 ----PRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSG 380
                ||.||..       |....:|....|:.|.:::...:      .|||           ||.
Human   454 LKRCPRELPPT-------LLGNSSEEESQLETNVTYWEEEQ------EFEV-----------VST 494

  Fly   381 LTLDKVHRGVLL------SEGNMVKLVL-------FIIVPICCILMLCSLTFC----------RR 422
            |.|..|.|.:.:      :.|...:.|:       |.:|.|..||.|..||..          ::
Human   495 LRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKK 559

  Fly   423 NRSEVQALQMDAKDAKASEF-HLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAF 486
            .|.|::...:::..:...|: ::..|             .|......|:....::|...||.|||
Human   560 PRYEIRWKVIESVSSDGHEYIYVDPM-------------QLPYDSTWELPRDQLVLGRTLGSGAF 611

  Fly   487 GLV----RRGVYKKR---QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSN 544
            |.|    ..|:...:   :||||:||......:..|...|::::..:|.|.|:|.::|..|: ..
Human   612 GQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTK-GG 675

  Fly   545 QMMLLIEYCSLGSLQNFL-REEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNS 608
            .:.::.|||..|.|.::| |.:..|            |:.:.|.|   |.|...::.....:...
Human   676 PIYIITEYCRYGDLVDYLHRNKHTF------------LQHHSDKR---RPPSAELYSNALPVGLP 725

  Fly   609 MLSTVEEESESDQTHSSRCETYTLTRITNAADNKGY-GLEDIENIGGSYIPKTAEAPKDRPKRKL 672
            :.|.|....|||                     .|| .:...|::  .|:|..
Human   726 LPSHVSLTGESD---------------------GGYMDMSKDESV--DYVPML------------ 755

  Fly   673 KPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIP--------------LKYADLLDIAQ 723
                      |.|.|.|....|:..|....|  :..|..|              |.|.||:..:.
Human   756 ----------DMKGDVKYADIESSNYMAPYD--NYVPSAPERTCRATLINESPVLSYMDLVGFSY 808

  Fly   724 QVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLAL 788
            |||.||||||....||||||||||||...:.:||.||||:||:..::.| .|.||..||:||:|.
Human   809 QVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY-ISKGSTFLPLKWMAP 872

  Fly   789 ESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSD-LLQLLRQGHRMKRPEGCTQEMFSLM 852
            ||:.:.:||:.|||||||:||:||.||||.|||.:..:: ....:::|:||.:|...:.|::.:|
Human   873 ESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIM 937

  Fly   853 ESCWSSVPSHRPTFSALKHRLGGMILATNDVPERL------KQLQAATESKLKS 900
            :.||......||.||.|...|           |||      |:.|...|..|:|
Human   938 QKCWEEKFEIRPPFSQLVLLL-----------ERLLGEGYKKKYQQVDEEFLRS 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	13/61 (21%)
		STYKc	475..873	CDD:214568	132/421 (31%)
		PTKc	479..873	CDD:270623	131/417 (31%)
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653	14/50 (28%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	14/55 (25%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	21/133 (16%)
		Ig	425..523	CDD:299845	26/147 (18%)
		PTKc_PDGFR_beta	562..953	CDD:133238	135/467 (29%)
		Pkinase_Tyr	600..953	CDD:285015	130/416 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5472
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960