DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tor and PDGFRA

DIOPT Version :10

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_001334757.1 Gene:PDGFRA / 5156 HGNCID:8803 Length:1114 Species:Homo sapiens


Alignment Length:905 Identity:223/905 - (24%)
Similarity:356/905 - (39%) Gaps:259/905 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 LPGLESNSTHNITALAMHGDGSYSLIA----------KDQTFATLIRGY---QP--SKMGAVNLL 185
            :|.::...|..:....:...|.|...|          |..|.:...:|:   :|  |::.|||| 
Human   291 VPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNL- 354

  Fly   186 RFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPL-----------EVQFRDRKKL 239
                  .::.|...|:...|...       :|:..|::.:.|.|           |:::|.:.||
Human   355 ------HEVKHFVVEVRAYPPPR-------ISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKL 406

  Fly   240 YR--------HTV--DNLEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPH 294
            .|        :|:  .|.:..|.|     |..::.::.|          |.||       |...|
Human   407 IRAKEEDSGHYTIVAQNEDAVKSY-----TFELLTQVPS----------SILD-------LVDDH 449

  Fly   295 KPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITV 359
            .......|.:           ..|....|||...:...|:.|...|.::|:..|.    |..|..
Human   450 HGSTGGQTVR-----------CTAEGTPLPDIEWMICKDIKKCNNETSWTILANN----VSNIIT 499

  Fly   360 LGSHFEVHLVAQSAGGKNVSG-LTLDKVH---------RGVLLSEGNMVK--------------- 399
                 |:|    |.....|.| :|..||.         :.:|.:|...:|               
Human   500 -----EIH----SRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAA 555

  Fly   400 -LVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEF-HLSLMDSSGLLVTLSANESL 462
             |||.:||.|..|:::  :.:.::.|.|::...:::......|: ::..|             .|
Human   556 VLVLLVIVIISLIVLV--VIWKQKPRYEIRWRVIESISPDGHEYIYVDPM-------------QL 605

  Fly   463 EVMDELEVEPHSVLLQDVLGEGAFGLVRRGV-------YKKRQVAVKLLKDEPNDEDVYAFKCEI 520
            ......|.....::|..|||.||||.|..|.       ....:||||:||......:..|...|:
Human   606 PYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 670

  Fly   521 QMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNV 585
            :::..:|.|.|||.::|..|: |..:.::.|||..|.|.|:|.:                     
Human   671 KIMTHLGPHLNIVNLLGACTK-SGPIYIITEYCFYGDLVNYLHK--------------------- 713

  Fly   586 DNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAAD--NKGYGLED 648
                 ||              :|.||...|:.:.:      .:.:.|    |.||  .:.|.:..
Human   714 -----NR--------------DSFLSHHPEKPKKE------LDIFGL----NPADESTRSYVILS 749

  Fly   649 IENIGGSYIPKTAEAPKDRPKRKLKPQPK----KDSKQDFKSDNKKRIFENKEYFDCLDSSDTKP 709
            .||.|.....|.|:..:..|..:.|...|    :.|..|..:..||:...:.|..:.|...::: 
Human   750 FENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE- 813

  Fly   710 RIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRK 774
              .|...|||....|||.||||||....|||||||||||::..:.:||.||||:||:.|::.| .
Human   814 --GLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY-V 875

  Fly   775 SGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRM 838
            |.||..||:||:|.||:...:||:.|||||:|:||:||.:|||.|||.:. .|.....::.|:||
Human   876 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRM 940

  Fly   839 KRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQ-------------- 889
            .:|:..|.|::.:|..||:|.|..||:|..|..      :..|.:|.:.|:              
Human   941 AKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE------IVENLLPGQYKKSYEKIHLDFLKSDH 999

  Fly   890 -----------------LQAATESKLKSCD-GLNSK--------------VEQVPCEEEL 917
                             .....|.|||..: ||:.:              ::.||.||:|
Human  1000 PAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDL 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 PTKc 479..873 CDD:270623 135/407 (33%)
PDGFRANP_001334757.1 Ig_3 53..125 CDD:464046
IgI_PDGFR-alphabeta 237..335 CDD:409447 7/43 (16%)
Ig strand A 237..241 CDD:409447
Ig strand A' 248..252 CDD:409447
Ig strand B 254..263 CDD:409447
Ig strand C 268..273 CDD:409447
Ig strand C' 276..278 CDD:409447
Ig strand D 282..290 CDD:409447
Ig strand E 294..302 CDD:409447 1/7 (14%)
Ig strand F 312..318 CDD:409447 1/5 (20%)
Ig strand G 323..329 CDD:409447 0/5 (0%)
Ig4_PDGFR 338..438 CDD:409445 24/118 (20%)
PTKc_PDGFR_alpha 580..981 CDD:173653 142/474 (30%)
Blue background indicates that the domain is not in the aligned region.

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