Protein Alignment tor and Eph

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Alignment Length: 840
• Identity: 175/840 - (20%)
• Similarity: 296/840 - (35%)
• Gaps: 337/840 - (40%)

  Fly   102 TEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQT 166
            |...|..||.:::.|:                        ||..:|.....|.:.|..:...|..
  Fly   459 TNLEPVTTYTVQIHAI------------------------NSVSHINEFKRHSNESSLVAVSDIV 499

  Fly   167 FATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEV 231
            |         |....:|:      |.||:.:..     ..||       :.::|.||.:.
  Fly   500 F---------SNTSLLNI------PLDLNEVKT-----GQAE-------IVFTTESVLLS----- 532

  Fly   232 QFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESDLQW-LPIAVPSCLDWYPYNYTLCPPHK 295
                       ||.||          |.:.|.|: ::||:| .|:.....|::|
  Fly   533 -----------TVFNL----------RILAITNK-DADLEWDKPVQSDFPLEFY----------- 564

  Fly   296 PENLTVTQKQYLP-------NILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFY 353
                   :.::.|       |..|||....:         .||..|.: .||..:.:....::.:
  Fly   565 -------EVRWFPKVELDAINKSALNTKETK---------AHIVGLLE-NTEYGFQVRCKTNNGF 612

  Fly   354 VPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLT 418
                   ||:..: :.||:.  ::|..:..|.|.  :....|.:|..|||::     |.::.::.
  Fly   613 -------GSYSNM-IYAQTL--QSVGSVYDDSVQ--IRFIAGAIVTGVLFLV-----IFIIATVY 660

  Fly   419 FCRRNRSEVQALQMDAKDAKASEFHLSL-----------MDSSGLLVTLSANESLEVMDELE--V 470
            |.|....:    .:|    |.|..||.|           ||::.::..|..|.:..:.....  |
  Fly   661 FMRSKHQD----DLD----KKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYV 717

  Fly   471 EPHS-------------------VLLQDVLGEGAFGLVRRGVYK-------KRQVAVKLLKDEPN 509
            :||:                   :.::.::|.|.||.|.||..|       ...||:|.||...:
  Fly   718 DPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSS 782

  Fly   510 DEDVYAFKCEIQMLKAVGK--HPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQ 572
            ::....|..|..::   |:  |||::.:.|..|| ||.:|::.||...|||..|||
  Fly   783 EKARCDFLTEASIM---GQFDHPNVIYLQGVVTR-SNPVMIITEYMENGSLDTFLR--------- 834

  Fly   573 NAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITN 637
                                            :|:....|::
  Fly   835 --------------------------------VNDGKFQTLQ----------------------- 844

  Fly   638 AADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCL 702
                                                                             
  Fly   845 ----------------------------------------------------------------- 844

  Fly   703 DSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVY 767
                           |:.:.:.:|.||.:|:....|||||||||||::.....|||||||||::.
  Fly   845 ---------------LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE 894

  Fly   768 H-ENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQL 831
            : .:.|...|  ||:|::|.|.|::..:.:||.|||||:||:|:|:.:.|..||.:.|..|:::.
  Fly   895 NASDAYTTRG--GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS 957

  Fly   832 LRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGM------ILATNDVPE 885
            :.:|:|:..|..|.:.::.||..||....:|||||:::...|..:      :|.|...||
  Fly   958 IEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPE 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	97/403 (24%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	5/40 (13%)
		FN3	536..623	CDD:238020	24/133 (18%)
		EphA2_TM	640..738	CDD:464211	21/110 (19%)
		PTKc_EphR	736..1002	CDD:270629	98/415 (24%)
		SAM_1	1029..1092	CDD:425739