Protein Alignment tor and InR

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 907
• Identity: 190/907 - (20%)
• Similarity: 327/907 - (36%)
• Gaps: 320/907 - (35%)

  Fly   119 DDNK-------ETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQP 176
            ||.|       |.||    .||:.:|.:..:...:    :...||:..        |.|.....|
  Fly  1025 DDRKVQAGMEFENAL----QNFIFVPNIRKSKNGS----SDKSDGAEG--------AALDSNAIP 1073

  Fly   177 SKMGAVNLLR------FVPQPDD------LHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPL 229
            :. ||.|..|      ..|:.||      |.|:.:..:     :::.:|:
  Fly  1074 NG-GATNPSRRRRDVALEPELDDVEGSVLLRHVRSITD-----DTDAFFE--------------- 1117

  Fly   230 EVQFRDRKKLYRHTVDNLEFDKQ-YHVGVR------TVNIMNRLESDLQWLPIAVPSCLDWYP-- 285
                :|.:..|:...| |..:|| |.|..:      |..:..:|....:: .|.|.:|.:..|
  Fly  1118 ----KDDENTYKDEED-LSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRY-AIFVVACREEIPSE 1176

  Fly   286 ------YNYTLCPPHKPENLTVTQKQYLPNILAL--------------NITWARPRYLPDNYTLH 330
                  :..:||..:.....|..:|::...::.|              .:.|..|  :..|..:.
  Fly  1177 KLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPP--VDPNGEIV 1239

  Fly   331 IFDLFKGGTELNYTL---DQNRSHFYVPKITVLGSHFEVHLVAQSAGG--KNVSGLTLDKVHRGV 390
            .:       |:.|.|   ||......:|     .:.|.     |:||.  |...||...:|....
  Fly  1240 TY-------EVAYKLQKPDQVEEKKCIP-----AADFN-----QTAGYLIKLNEGLYSFRVRANS 1287

  Fly   391 LLSEGNMVKL-------------VLFIIVPICCILMLCSL--TFCRRNRSEVQA--LQMDAKDAK 438
            :...|:..::             |.|.::.|....::.||  ..|..::.:|.:  |.|   :.:
  Fly  1288 IAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHM---NTE 1349

  Fly   439 ASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKK------- 496
            .:.|:.|:.               .:.|:.||...:::....||:|:||:|..|:.|.
  Fly  1350 VNPFYASMQ---------------YIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVD 1399

  Fly   497 RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNF 561
            |:.|:|.:.:...|.:...|..|..::|....: ::|.::|..:| ....::::|....|.|:::
  Fly  1400 RECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSR-GQPALVVMELMKKGDLKSY 1462

  Fly   562 LREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSR 626
            ||..                                   |.|:.:.:|:
  Fly  1463 LRAH-----------------------------------RPEERDEAMM---------------- 1476

  Fly   627 CETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKR 691
              || |.||               .:.|:..|.|
  Fly  1477 --TY-LNRI---------------GVTGNVQPPT------------------------------- 1492

  Fly   692 IFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIK 756
                                   |..:..:|.::|.||.:||..|.|||||||||.:::.|.::|
  Fly  1493 -----------------------YGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVK 1534

  Fly   757 IADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYP 821
            |.|||::||:|..:.||| |..|.||::|:..|||...||:|.|||:||||:|:|:.||...||.
  Fly  1535 IGDFGMTRDIYETDYYRK-GTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQ 1598

  Fly   822 SVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTF-------------------- 866
            .:|...:|:.:..|..|:|||.|...:..||:.||....|.||:|
  Fly  1599 GLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVS 1663

  Fly   867 -----SALKHR-----------LGGMILATNDVPERLKQLQAATESKLKSCDGLNSKVEQVP 912
                 :.|:||           ....:....|:.:|.:|..|.|..::.... .||.::|.|
  Fly  1664 FYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQ-QNSSLDQPP 1724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	106/436 (24%)
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	18/96 (19%)
		PTKc_InsR_like	1364..1652	CDD:173625	105/413 (25%)