DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and btl

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	216/933 - (23%)
Similarity:	325/933 - (34%)	Gaps:	350/933 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PNATYIIRVDAVKDDNKETAL-------YLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAK 163
            |..|::.:.:|   ||.:..|       .|..|...::..::......:..:.|...|.|..||:
  Fly   271 PKITWLHKGNA---DNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAE 332

  Fly   164 DQTFATLIRG----YQPSKMGAVNLLRFV----PQP---------DDLHHIAAEIE---WKPSAE 208
            :|...|:...    |.||....|......    |.|         ||:.:.|||..   ..|...
  Fly   333 NQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFR 397

  Fly   209 SNCYFDMVSYSTNSVNMDEPL----EVQFRDRKK---------------------------LYRH 242
            ........|.|.|:||:..|:    .:.:...||                           ||..
  Fly   398 KELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNC 462

  Fly   243 TVDN----LEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTL---------CPPH 294
            .|.|    ::||....:..||           :..||.|      .|.|.|:         |..:
  Fly   463 KVCNAWGCIQFDFSVQINDRT-----------RSAPIIV------VPQNQTVKVNGSLVMKCTVY 510

  Fly   295 KPENLTVTQKQ-YLPN----------ILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQ- 347
            ...:.||:.|: .|.|          |..||.|...     |:..|         |..|.|.||
  Fly   511 SDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTN-----DSVVL---------TLRNVTFDQE 561

  Fly   348 -----------NRSH--------------------------FYVPKITV-----LGSHFEVHLVA 370
                       .||:                          |.:..||:     |||.|...::.
  Fly   562 GWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLR 626

  Fly   371 QSAGGKNVSGLTLDKVHR--------------GVLLSEGNMVKLVLFIIVPICCILMLCSLTFCR 421
            :....|.:. |.::.||:              |...|.|::...|:.|                .
  Fly   627 RLRREKLLK-LRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRI----------------E 674

  Fly   422 RNRSEVQALQMDAKDAKA--SEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEG 484
            :.|:.|........|...  :|:...| ||:                 .|:....:.|..:||||
  Fly   675 KQRTTVSTTGTGGTDPAQGFNEYEFPL-DSN-----------------WEIPRQQLSLGSILGEG 721

  Fly   485 AFGLV----RRGVYKKRQ-----VAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYST 540
            |||.|    ..|:.:..|     ||||::|:|..|.|:.:...|::::|.:|||.||:.::|..:
  Fly   722 AFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCS 786

  Fly   541 RFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDI 605
            : ...:.:::||...|:|::||:        ||..|        ...||
  Fly   787 Q-GGPLWVIVEYAPHGNLKDFLK--------QNRPG--------APQRR---------------- 818

  Fly   606 NNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKR 670
                                             :|:.||
  Fly   819 ---------------------------------SDSDGY-------------------------- 824

  Fly   671 KLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKY---ADLLDIAQQVAVGMEFL 732
                                              .|.||.|..::   .:|...|.|:|.|||:|
  Fly   825 ----------------------------------LDDKPLISTQHLGEKELTKFAFQIARGMEYL 855

  Fly   733 AQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYT 797
            |..:.:||||||||||:|....:|||||||:||:.....|||: .:|:|||||:|.|||..:.|.
  Fly   856 ASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKN-TNGRLPIKWMAPESLQEKKYD 919

  Fly   798 SQSDVWSFGVLLYEITTLGGMPYPSV-SPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPS 861
            |||||||:||||:||.|.|..|||.: |..:|...|..|.||::|..|:..::.:|..||.....
  Fly   920 SQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESC 984

  Fly   862 HRPTFSALKHRLGGMILATNDVP 884
            .||||:.|.....|::...:..|
  Fly   985 ARPTFAELVESFDGILQQASSNP 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	19/99 (19%)
		STYKc	475..873	CDD:214568	122/410 (30%)
		PTKc	479..873	CDD:270623	121/406 (30%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	14/67 (21%)
		Ig	258..340	CDD:143165	15/71 (21%)
		I-set	394..479	CDD:254352	15/84 (18%)
		IGc2	408..469	CDD:197706	11/60 (18%)
		IG_like	492..583	CDD:214653	22/104 (21%)
		Ig	507..583	CDD:299845	19/89 (21%)
		PKc_like	700..1000	CDD:304357	127/444 (29%)
		TyrKc	712..996	CDD:197581	122/410 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010