Protein Alignment tor and LCK

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_001426075.1
• Gene: LCK / 3932
• HGNCID: 6524
• Length: 567
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 149/656 - (22%)
• Similarity: 229/656 - (34%)
• Gaps: 248/656 - (37%)

  Fly   272 WLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDL-F 335
            :|||         |..::|.|....:||.:....|.|:                    |..|| |
Human   105 FLPI---------PARFSLMPLVFTDNLVIALHSYEPS--------------------HDGDLGF 140

  Fly   336 KGGTELNYTLDQNRSHFYVPKITVLGSHF-EVHLVAQSAG-------GKNVSGLTLDKVHRGVLL 392
            :.|.:|. .|:|:...:....:|.....| ..:.||::..       .||:|....::    .||
Human   141 EKGEQLR-ILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAER----QLL 200

  Fly   393 SEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASE------FHLSLMDSSG 451
            :.||.....|.                 |.:.|...:..:..:|...::      :.:..:|:.|
Human   201 APGNTHGSFLI-----------------RESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGG 248

  Fly   452 LLVT---------------LSANESLEVM----------------DELEVEPHSVLLQDVLGEGA 485
            ..::               .:|::.|...                ||.||...::.|.:.||.|.
Human   249 FYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQ 313

  Fly   486 FGLVRRGVYK-KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLL 549
            ||.|..|.|. ..:||||.||......|  ||..|..::|.: :|..:|.:  |:......:.::
Human   314 FGEVWMGYYNGHTKVAVKSLKQGSMSPD--AFLAEANLMKQL-QHQRLVRL--YAVVTQEPIYII 373

  Fly   550 IEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVE 614
            .||...|||.:||:
Human   374 TEYMENGSLVDFLK--------------------------------------------------- 387

  Fly   615 EESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKD 679
                                                                             
Human   388 ----------------------------------------------------------------- 387

  Fly   680 SKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAA 744
                                       |...|.|....|||:|.|:|.||.|:.:...:||||.|
Human   388 ---------------------------TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRA 425

  Fly   745 RNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLL 809
            .|:|:|...|.|||||||:| :..:|.|....|: |.||||.|.|::.:..:|.:|||||||:||
Human   426 ANILVSDTLSCKIADFGLAR-LIEDNEYTAREGA-KFPIKWTAPEAINYGTFTIKSDVWSFGILL 488

  Fly   810 YEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLG 874
            .||.|.|.:|||.::..:::|.|.:|:||.||:.|.:|::.||..||...|..||||..|:..|.
Human   489 TEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 553

  Fly   875 GMILAT 880
            ....||
Human   554 DFFTAT 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	104/394 (26%)
LCK	NP_001426075.1	None