DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and KDR

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_002244.1	Gene:	KDR / 3791	HGNCID:	6307	Length:	1356	Species:	Homo sapiens

Alignment Length:	954	Identity:	239/954 - (25%)
Similarity:	370/954 - (38%)	Gaps:	312/954 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 YQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGLES 141
            :|:...|..|......:        |.|.|...:    .:|:|......:.::.:.|.::.|  .
Human   460 WQLEEECANEPSQAVSV--------TNPYPCEEW----RSVEDFQGGNKIEVNKNQFALIEG--K 510

  Fly   142 NST--------HNITAL--------AMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNL------ 184
            |.|        .|::||        ...|:...|.........||....||::..:|:|
Human   511 NKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADR 575

  Fly   185 --------LRFVPQPDDLH------HIAAEIE--WKPSAESNCYFDMVSYSTNSVNMDE----PL 229
                    .:..|||..:|      .:...::  ||.:|      .|.|.|||.:.:.|    .|
Human   576 STFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNA------TMFSNSTNDILIMELKNASL 634

  Fly   230 EVQ------FRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNR----LESDLQWLPIAVPSCLDWY 284
            :.|      .:|||...||.|            ||.:.::.|    :..:|:....::...::
Human   635 QDQGDYVCLAQDRKTKKRHCV------------VRQLTVLERVAPTITGNLENQTTSIGESIE-- 685

  Fly   285 PYNYTLC-----PPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFD---LFKGGTEL 341
                ..|     ||              |.|:     |.:     ||.|| :.|   :.|.|..
Human   686 ----VSCTASGNPP--------------PQIM-----WFK-----DNETL-VEDSGIVLKDGNR- 720

  Fly   342 NYTLDQNRSH----FYVPKITVLG-SHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLV 401
            |.|:.:.|..    :.....:||| :..|...:.:.|         .:|.:..:::..|..|..:
Human   721 NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGA---------QEKTNLEIIILVGTAVIAM 776

  Fly   402 LFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSL-MDSSGLLVTLSANESLEVM 465
            .|.:     :|::...|..|.|..|::.            .:||: ||.
Human   777 FFWL-----LLVIILRTVKRANGGELKT------------GYLSIVMDP---------------- 808

  Fly   466 DELEVEPH----------------SVLLQDVLGEGAFGLVRR----GVYKK---RQVAVKLLKDE 507
            |||.::.|                .:.|...||.||||.|..    |:.|.   |.||||:||:.
Human   809 DELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEG 873

  Fly   508 PNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREE------- 565
            ....:..|...|:::|..:|.|.|:|.::|..|:....:|:::|:|..|:|..:||.:
Human   874 ATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPY 938

  Fly   566 ----WKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLST----VEEESESDQT 622
                .:|||.::.:|...     ||.:|           |::.|.:|..|.    |||:|
Human   939 KTKGARFRQGKDYVGAIP-----VDLKR-----------RLDSITSSQSSASSGFVEEKS----- 982

  Fly   623 HSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSD 687
                                   |.|:|.         .|||:|..|             ||
Human   983 -----------------------LSDVEE---------EEAPEDLYK-------------DF--- 999

  Fly   688 NKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVD 752
                                     |....|:..:.|||.||||||..|.:||||||||:|:|..
Human  1000 -------------------------LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEK 1039

  Fly   753 RSIKIADFGLSRDVYHENVY-RKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLG 816
            ..:||.||||:||:|.:..| ||  |..:||:||:|.|::..:|||.|||||||||||:||.:||
Human  1040 NVVKICDFGLARDIYKDPDYVRK--GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLG 1102

  Fly   817 GMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILAT 880
            ..|||.|. ..:..:.|::|.||:.|:..|.||:..|..||...||.|||||.|...||.::.|.
Human  1103 ASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQAN 1167

  Fly   881 --NDVPERLKQLQAATESKLKSCDGLNSKVEQVPC-EEELYLEP 921
              .|..:.: .|..:....::...||:.....|.| |||...:|
Human  1168 AQQDGKDYI-VLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDP 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	19/73 (26%)
		STYKc	475..873	CDD:214568	140/421 (33%)
		PTKc	479..873	CDD:270623	139/417 (33%)
KDR	NP_002244.1	Ig	41..109	CDD:299845
		IG_like	231..324	CDD:214653
		Ig1_VEGFR	239..326	CDD:143270
		IG_like	340..417	CDD:214653
		Ig2_VEGFR-2	348..417	CDD:143272
		Ig_2	551..661	CDD:290606	29/127 (23%)
		IG	565..661	CDD:214652	25/113 (22%)
		I-set	667..754	CDD:254352	21/118 (18%)
		IGc2	680..744	CDD:197706	17/95 (18%)
		PTKc_VEGFR2	826..1167	CDD:270681	142/436 (33%)
		Pkinase_Tyr	834..1160	CDD:285015	140/421 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1318
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910