Protein Alignment tor and Blk

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: XP_006252250.1
• Gene: Blk / 364403
• RGDID: 1308859
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 736
• Identity: 170/736 - (23%)
• Similarity: 255/736 - (34%)
• Gaps: 269/736 - (36%)

  Fly   217 SYSTNSVNMDEPLEVQFRDRKKLYRHTV---DNLEFDKQYHVGVRTVNIMNRLESDLQ------- 271
            ||.|:|.:: .||..:....|:|:|...   |:.|........:|....|..|.|..|
  Rat     8 SYKTSSCDL-RPLAEEVSTPKRLWRQLSWGRDSAESASMPCGLLRLFLRMGLLSSKRQISEKSKS 71

  Fly   272 WLPIAV-------PSCLDWYPYNYTLCPPHKP----------------------ENLTVTQKQYL 307
            |.|:..       |.......:|:  .||..|                      .:|.|.:.:.|
  Rat    72 WSPVKARAQGKVPPPLPPLVVFNH--LPPPSPNQHPDEEERFVVALFDYAAVNDRDLQVLKGEKL 134

  Fly   308 PNI-------LALNITWARPRYLPDNY-----TLHIFDLF-----KGGTELNYTLDQNRSHFYVP 355
            ..:       ||.::...|..|:|.|:     ||.:...|     :...|.......|::
  Rat   135 QVLKSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKA----- 194

  Fly   356 KITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVL--------FIIVPICCIL 412
                 ||    .|:.:|...|....|::..|     .|:|.|||...        :.|.|
  Rat   195 -----GS----FLIRESESNKGAFSLSVKDV-----TSQGEMVKHYKIRSLDNGGYYISP----- 240

  Fly   413 MLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLS------ANESLEVMDELEVE 471
               .:||     ..:|||..          |.| ....||...|:      |.::....||.|:.
  Rat   241 ---RITF-----PTLQALVQ----------HYS-EKGDGLCQKLTLPCVNPAPKNPWAQDEWEIP 286

  Fly   472 PHSVLLQDVLGEGAFGLVRRGVYKKR-QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGI 535
            ..|:.|...||.|.||.|..|.||.. :||:|.||:.....:  ||..|..::|.: :|..:|.:
  Rat   287 RQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPE--AFLGEANVMKTL-QHERLVRL 348

  Fly   536 VGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHD 600
            ....||  ..:.::.||.:.|.|.:||
  Rat   349 YAVVTR--EPIYIVTEYMARGCLLDFL-------------------------------------- 373

  Fly   601 RIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPK 665
                                                                             
  Rat   374 ----------------------------------------------------------------- 373

  Fly   666 DRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGME 730
                               |:|...|:              :.||       |:|::.|||.||.
  Rat   374 -------------------KTDEGSRL--------------SLPR-------LIDMSAQVAEGMA 398

  Fly   731 FLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQV 795
            ::.:...:||||.|.|:|:|.....|||||||:|.:  ::.|....|: |.||||.|.|::...|
  Rat   399 YIERMNSIHRDLRAANILVSETLCCKIADFGLARII--DSEYTAQEGA-KFPIKWTAPEAIHFGV 460

  Fly   796 YTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMF-SLMESCWSSV 859
            :|.::|||||||||.||.|.|.:|||.:|..::::.|..|:||..||.|..|:: .::..||...
  Rat   461 FTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYHDVITECWRGR 525

  Fly   860 PSHRPTFSALKHRLGGMILAT 880
            |..||||..|:..|.....||
  Rat   526 PEERPTFEFLQSVLEDFYTAT 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	100/395 (25%)
Blk	XP_006252250.1	SH3	111..164	CDD:473055	9/52 (17%)
		SH2	169..268	CDD:472789	27/141 (19%)
		Protein Kinases, catalytic domain	282..545	CDD:473864	105/413 (25%)