DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and fgfr2

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_005169609.1	Gene:	fgfr2 / 352940	ZFINID:	ZDB-GENE-030323-1	Length:	836	Species:	Danio rerio

Alignment Length:	1048	Identity:	241/1048 - (22%)
Similarity:	376/1048 - (35%)	Gaps:	410/1048 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GEMLLMD--KISHDKTLLNVTACTQNCLEKGQMDFRSCLKDCRINGTFPGALRKVQENYQMNMIC 83
            |.:|||.  .:|..:..|.:.....:..|:.....::|:.  .:....||.|.|::        |
Zfish    32 GALLLMTLATVSVARPSLKIDLVNTSAPEEPPTKNQNCVP--VLFSVHPGELLKLK--------C 86

  Fly    84 -----------------RTESEIVFQIDWVQHSRGTEPAPNATY---------------IIRV-D 115
                             |.::..:...||:|.|..| |..:..|               |:.| |
Zfish    87 PLSGADDVVWTKDSSSLRPDNRTLVTRDWLQISDAT-PKDSGLYSCSATGSRDCDVFSFIVNVTD 150

  Fly   116 AVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQPSKM- 179
            |:...:.|.....|||                    :..||....:.. .||        |.||
Zfish   151 AISSGDDEDDTERSDD--------------------VGADGEQMRLPY-WTF--------PEKME 186

  Fly   180 ------GAVNLLRF------VPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQ 232
                  .|.|.::|      .|:|        ::.|..:|:                       .
Zfish   187 KKLHAVPAANTVKFRCAAAGNPKP--------KMRWLKNAK-----------------------P 220

  Fly   233 FRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESDLQWLPI---AVPS------CLDWYPY-- 286
            ||...::..:.|                    ||:   .|..|   .|||      ||....|
Zfish   221 FRQEDRMGGYKV--------------------RLQ---HWTLIMESVVPSDKGNYTCLVENQYGS 262

  Fly   287 ---NYTL----CPPHK-------PENLTVTQKQYLPNILAL------NITWAR------PRYLPD 325
               .|||    ..||:       |.|:||...|....:..:      :|.|.:      .||.||
Zfish   263 INHTYTLDVVERSPHRPILQAGLPANVTVQVGQDAKFVCKVYSDAQPHIQWLQHYTKNGSRYGPD 327

  Fly   326 NYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVL------GSHFEV----HLVAQSAGG----- 375
            .                           :|.:.||      .|..||    ::..:.||.
Zfish   328 G---------------------------LPYVRVLKSSGINSSDVEVLMLTNVTEEDAGEITCKV 365

  Fly   376 KNVSGLTLDKVHRGVLLSEGNMVKLVL---FIIVPICCI---LMLCSLTF---CRRNRS------ 425
            .|..|...:.....|:.:|.|.::...   ::.:.|.||   |:.|.:..   ||...|
Zfish   366 SNYIGEANNSCWLIVIPAETNPIETDYPPDYVEIAIYCIGVFLIACMVVIVVVCRMRTSAKKPDF 430

  Fly   426 -----------EVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVMD-----ELEVEPH- 473
                       ::...:..:.|:.:|      |.||..||.::...|....|     :|..:|.
Zfish   431 SSQPAVHKLTKQIPLRRQVSSDSSSS------MSSSTPLVRITTRRSSAHDDPIPEYDLPEDPRW 489

  Fly   474 -----SVLLQDVLGEGAFGLV----RRGVYKKR-----QVAVKLLKDEPNDEDVYAFKCEIQMLK 524
                 .:.|...||||.||.|    ..|:.|.:     .||||:|||:..::|:.....|::|:|
Zfish   490 EFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 554

  Fly   525 AVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRR 589
            .:|:|.||:.::|..|: ...:.:::||.|.|:|:.:||.
Zfish   555 MIGRHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLRA------------------------- 593

  Fly   590 FNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGG 654
              |.|....:                             :|.:.|:::.
Zfish   594 --RRPPGMEY-----------------------------SYDIARVSDE---------------- 611

  Fly   655 SYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLL 719
                                                                     ||.:.||:
Zfish   612 ---------------------------------------------------------PLTFKDLV 619

  Fly   720 DIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIK 784
            ....|||.|||:||..|.:||||||||||::....:|||||||:|||::.:.|:|: .:|:||:|
Zfish   620 SCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKT-TNGRLPVK 683

  Fly   785 WLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMF 849
            |:|.|:|..:|||.||||||||||::||.||||.|||.:...:|.:||::||||.:|..||.|::
Zfish   684 WMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELY 748

  Fly   850 SLMESCWSSVPSHRPTFSALKHRLGGMI-LATN----DVPERLKQLQAATESKLKSC-DGLNSKV 908
            .:|:.||.::.||||||..|...|..:: ||||    |:...::|...:......|| .|.:|..
Zfish   749 MMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLDLCAPVEQYSPSFPDTRSSCSSGDDSVF 813

  Fly   909 EQVPCEEE 916
            ...|..:|
Zfish   814 SHDPLADE 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	5/61 (8%)
		STYKc	475..873	CDD:214568	124/406 (31%)
		PTKc	479..873	CDD:270623	123/402 (31%)
fgfr2	XP_005169609.1	Ig	71..148	CDD:299845	14/87 (16%)
		IG_like	75..148	CDD:214653	14/81 (17%)
		Ig2_FGFR	187..271	CDD:143265	23/137 (17%)
		IG_like	197..271	CDD:214653	21/127 (17%)
		IG_like	286..380	CDD:214653	21/120 (18%)
		Ig	294..381	CDD:299845	17/113 (15%)
		PTKc_FGFR2	471..783	CDD:270679	133/442 (30%)
		Pkinase_Tyr	496..772	CDD:285015	124/406 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910