DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and tek

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_009299388.1	Gene:	tek / 30747	ZFINID:	ZDB-GENE-990415-56	Length:	1117	Species:	Danio rerio

Alignment Length:	959	Identity:	216/959 - (22%)
Similarity:	345/959 - (35%)	Gaps:	305/959 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 CTQNCL-EKGQMD-FRSCL------KDCRINGTFP--GALRKVQEN--YQMNMICRTESEIVFQI 93
            |||.|: .||:.| ||.|:      ..|....:.|  ..||.|:.|  .::::.|
Zfish   314 CTQKCVCAKGRCDRFRGCVCAGRHGSRCEEADSSPVISHLRDVEINTGVELSVNC---------- 368

  Fly    94 DWVQHSRGTEPAP----------NATYIIRVDAVKDDNKETALYLSDDNFLILPG---LESNSTH 145
                 |....|||          |.|.|..||....:::.|:::......:...|   .:.|:||
Zfish   369 -----SASGRPAPLHGDITLITANRTTIAAVDTHTLNDQSTSVFRVQQVRVSSAGRWRCQVNNTH 428

  Fly   146 -----NITA-----------LAMHGDGSYSLIAKDQTFATLIRGYQP-SKMGAVNLLRFVPQPDD 193
                 ..|.           ..:.|.|...|:        |:...:| |..|.:.....:.:|..
Zfish   429 AQVEDEFTVEVKVPPRPQNPPVLQGSGPRHLL--------LLLNTEPYSGDGPIATTTLLYRPAS 485

  Fly   194 LHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVR 258
            .|..::.....|....:..:.|..|.| .|.:..|..............:...||..    |||:
Zfish   486 AHTWSSFTAHGPLVRLDNLYPMTQYLT-QVQLSRPGPGGAGQAGPAATFSTQVLELP----VGVK 545

  Fly   259 TVNIMNRLESDLQW---------------LPIAVPSCLDWY--PYNYT------LCPPHKPENLT 300
             ::.:::....|.|               |....|..|..:  |.|.:      |.|.||.: .|
Zfish   546 -LSAVSQTALLLSWDIAPAEQHCTYEVSCLQAGAPGTLRTFQLPSNSSAMHLSDLKPRHKYQ-CT 608

  Fly   301 VTQK----QYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTL---------------- 345
            |...    |..|:..|.  |.:.|...|....:.|:::......|.:.:
Zfish   609 VRSSCGVGQNHPSASAW--TLSDPELPPPPANISIWNISDTSAVLTWAVAEGESVSRAVIRFQQV 671

  Fly   346 --DQNRSHFYVP--------KITVLGSH---------FEVHLVAQSAGGKNVSGLTLDKVHRGVL 391
              .|.|....:|        :..:||..         :.|:.:.:||....||.:||.:.....|
Zfish   672 EQAQYRQQVELPVQTQQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLMTLPQQESSAL 736

  Fly   392 L-SEGNMVKLVLFIIV----PICCILML--CSLTFCRRNRSEVQALQMDAKDAKASEF------- 442
            . :.|:   |:|:.|:    ..||.::|  |.:...:||..: :.:....::..|..|
Zfish   737 FAAHGH---LLLYAILGSAGMTCCTVLLAFCIVLQLKRNTLQ-RRIHSILREEPAVHFSSAPPPH 797

  Fly   443 HLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKK----RQVAVKL 503
            ..|.:.|..|:.     .:|:..|        :..|||||||.||.|.:...:|    ...|||.
Zfish   798 RRSAVVSRSLVF-----PALQWSD--------IQFQDVLGEGNFGQVLKARIRKDGLRMDAAVKR 849

  Fly   504 LKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKF 568
            :||..:.:|...|..|:::|..:|.|.||:.::| :......:.|.||:...|:|.:|||
Zfish   850 MKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLG-ACEHRGYLYLAIEFAPHGNLLDFLR----- 908

  Fly   569 RQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLT 633

Zfish   909 ----------------------------------------------------------------- 908

  Fly   634 RITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEY 698
                                                                   |.|:.|....
Zfish   909 -------------------------------------------------------KSRVLETDPA 918

  Fly   699 FDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLS 763
            |.....:.:    .|....||..:..||.||.:|:|.:.:||||||||||:..:...||||||||
Zfish   919 FAIAHRTAS----TLSSQQLLAFSADVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIADFGLS 979

  Fly   764 RDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDL 828
            |.   :.||.|. ..|:||::|:|:|||.:.|||:.|||||:||||:|:.:|||.||..::.::|
Zfish   980 RG---QEVYVKK-TMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAEL 1040

  Fly   829 LQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI 877
            .:.|..|.|:::|..|..|::.||:.||...|..||:||.:...||.|:
Zfish  1041 YEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSLGRML 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	11/61 (18%)
		STYKc	475..873	CDD:214568	110/401 (27%)
		PTKc	479..873	CDD:270623	109/397 (27%)
tek	XP_009299388.1	Ig_Tie2_1	25..121	CDD:287411
		EGF_2	224..255	CDD:285248
		IG_like	354..439	CDD:214653	19/99 (19%)
		fn3	541..621	CDD:278470	17/85 (20%)
		FN3	633..717	CDD:214495	9/83 (11%)
		PTKc_Tie2	809..1111	CDD:133219	115/428 (27%)
		STYKc	817..1085	CDD:214568	110/401 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100