Protein Alignment tor and Txk

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_001019426.1
• Gene: Txk / 305311
• RGDID: 1306481
• Length: 526
• Species: Rattus norvegicus
• Alignment Length: 623
• Identity: 128/623 - (20%)
• Similarity: 210/623 - (33%)
• Gaps: 247/623 - (39%)

  Fly   293 PHKPENLTVTQ-KQYL------PNILALNITWARPR-------YLPDNY-------TLHIFDLFK 336
            |.:|.||.:.: ::||      |:       |.|.|       .:|.||       .|..::.:
  Rat    94 PREPCNLALKRAEEYLILERCDPH-------WWRARDRLGNEGLIPSNYVTENRLTNLETYEWY- 150

  Fly   337 GGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLV 401
               ..|.|.||..                 .|:.|.|  |..:.:..|..|.|
  Rat   151 ---HKNITRDQTE-----------------RLLRQEA--KEGAFIVRDSRHLG------------ 181

  Fly   402 LFIIVPICCILMLCSLTFCRRN-RSEVQALQMDAKDA---KASEFHL----------------SL 446
                     ...:...|..||: :|.::..|:...|:   ..:|.||                .|
  Rat   182 ---------SYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVTERHLFPSVPELIQYHQYNAAGL 237

  Fly   447 MD----SSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKKR-QVAVKLLKD 506
            |.    ..|||.:.....|....::.|::|..:.....:|.|.||:|..|.::.| :||:|.:.:
  Rat   238 MSRLRYPVGLLGSCLPATSGFSYEKWEIDPSELTFVKEIGSGQFGVVYLGEWRARIRVAIKAINE 302

  Fly   507 EPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQE 571
            ....|:.:..:.::.|..:   |..:|.:.|...: ...:.::.|:...|.|.::|||
  Rat   303 GSMSEEDFIEEAKVMMKLS---HSRLVQLYGVCIQ-QKPLYIVTEFMENGCLLDYLRE------- 356

  Fly   572 QNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRIT 636
                             |..:||:
  Rat   357 -----------------RKGKLPK----------------------------------------- 363

  Fly   637 NAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDC 701
                                                                             
  Rat   364 ----------------------------------------------------------------- 363

  Fly   702 LDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDV 766
                          |.||.:.|.:..||.:|.::..:||||||||.|:|....:||:|||::|.|
  Rat   364 --------------ALLLSMCQDICEGMAYLEKSCYIHRDLAARNCLVSSACVVKISDFGMARYV 414

  Fly   767 YHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQL 831
            ..:.....||  .|.|:||...|......|:|:|||||||||::|:.|.|.||:.:.|...:::.
  Rat   415 LDDEYISSSG--AKFPVKWSPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEA 477

  Fly   832 LRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSAL 869
            :.:|.|:.||......::.:|.|||...|..||||:.|
  Rat   478 ISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAEL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	86/392 (22%)
Txk	NP_001019426.1	SH3_TXK	84..138	CDD:212840	13/50 (26%)
		SH2_Tec_Txk	142..247	CDD:198261	23/148 (16%)
		Protein Kinases, catalytic domain	265..520	CDD:473864	87/401 (22%)