DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and flt4

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_571020.2	Gene:	flt4 / 30121	ZFINID:	ZDB-GENE-980526-326	Length:	1368	Species:	Danio rerio

Alignment Length:	891	Identity:	220/891 - (24%)
Similarity:	349/891 - (39%)	Gaps:	260/891 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 NGTFPGALRKVQENYQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALY 127
            |.:.|...:.:.|    |.:.:.|..|.|.:..:......|..|:.      |.::.|..:  |.
Zfish   553 NASVPAMYKCLAE----NKVGKDERLIYFYVTTIPEGFDIEMEPSE------DPLEQDLVQ--LK 605

  Fly   128 LSDDNF-------------LILPGLESNSTHNITALAMHGDGSYSLIAKDQTFATLIRG---YQP 176
            .:.|||             .:.|.|:..|.|.                    :||.:.|   :|.
Zfish   606 CNADNFTYENLRWYRLDPQTVPPELDCKSLHQ--------------------YATFLEGQLSFQT 650

  Fly   177 SKMGAVNLLRFVP-QPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLY 240
            :....|..|.... |..|..:...|::.:.:...:|:...:....    |:.|          .|
Zfish   651 TSNNWVLQLNITNIQLQDEGNYVCEVQNRRTGVKHCHRKYIPVKA----MEAP----------RY 701

  Fly   241 RHTVDNLEFDKQYHVGVRTVNIMNRLE--SDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQ 303
            ||...|           .|||:...|:  .|::..|.  |. |.|:..|.   |.|:...:.:..
Zfish   702 RHNPTN-----------HTVNVSESLQMNCDVEGTPF--PQ-LSWFKDNQ---PLHQISGILLQD 749

  Fly   304 KQYLPNILALNITWARPRYLPDNYTLHIFDLF--KGGTELNYTLDQNRSHFYVPKITVLGSHFEV 366
            .         |.|.:..|...::..|:.....  ||..:.:.|            ::|:||.
Zfish   750 S---------NRTLSIQRVREEDAGLYTCSACNQKGCVQSSAT------------VSVIGSD--- 790

  Fly   367 HLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQ 431
                             ||.:..:::..|..|..:.|      .:|:|  :.||...|
Zfish   791 -----------------DKTNVEIVILIGTGVIAIFF------WVLLL--VIFCNVKR------- 823

  Fly   432 MDAKDAKASEFHLSLMDSSGLLVTLSANESLEVM----DELEVEPHSVLLQDVLGEGAFG-LVRR 491
            ::..|.|..  :||::...|   .:...|..|.:    .:.|:....:.|..|||.|||| ::..
Zfish   824 VNPADIKTG--YLSIIMDPG---EVPLEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEA 883

  Fly   492 GVY---KK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLI 550
            .::   ||   ..||||:||:.....:..|...|:::|..:|.|.|:|.::|..|:.:..:|:::
Zfish   884 SIFGHDKKSSANTVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIV 948

  Fly   551 EYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEE 615
            |||..|:|.||||.:.:|                       .||   ..||.....:.:...:|.
Zfish   949 EYCKYGNLSNFLRAKREF-----------------------FLP---YRDRSPKTQSQVRRMIEA 987

  Fly   616 ESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDS 680
            ...|...|.                                 |.|:
Zfish   988 GQASQSEHQ---------------------------------PSTS------------------- 1000

  Fly   681 KQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAAR 745
                 |.|..|:           :.|...:.||...||:..:.|||.||||||..|.:|||||||
Zfish  1001 -----STNPPRV-----------TVDDLWKTPLTIEDLICYSFQVARGMEFLASRKCIHRDLAAR 1049

  Fly   746 NVLISVDRSIKIADFGLSRDVYHENVY-RKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLL 809
            |:|:|.:..:||.||||:||:|.:..| ||  |:.:||:||:|.||:..:|||||||||||||||
Zfish  1050 NILLSENNVVKICDFGLARDIYKDPDYVRK--GNARLPLKWMAPESIFDKVYTSQSDVWSFGVLL 1112

  Fly   810 YEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRL 873
            :||.:||..|||.:. ..|..:.|:.|.||:.|:..:.|::.:|.:||...|..||||.||...|
Zfish  1113 WEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPTFPALVEIL 1177

  Fly   874 GGMILATNDVPERLKQLQAATESKLKSCDGLNSKVEQVPCEEELYL 919
            |. :|..|.:||....:..::|.     ||.:....:.|.:||:.|
Zfish  1178 GD-LLQENSLPEIPFNVSQSSED-----DGFSQASSRPPSQEEIRL 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	9/61 (15%)
		STYKc	475..873	CDD:214568	132/406 (33%)
		PTKc	479..873	CDD:270623	131/402 (33%)
flt4	NP_571020.2	IG_like	258..348	CDD:214653
		Ig1_VEGFR	265..350	CDD:143270
		IG_like	362..445	CDD:214653
		Ig	373..445	CDD:299845
		Ig	602..685	CDD:143165	17/104 (16%)
		IG	602..678	CDD:214652	17/97 (18%)
		I-set	705..786	CDD:254352	20/118 (17%)
		IGc2	714..776	CDD:197706	13/76 (17%)
		PKc_like	858..1184	CDD:304357	136/422 (32%)
		Pkinase_Tyr	866..1177	CDD:285015	132/406 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1007		7/85 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1212		4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910