DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Kdr

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_037194.2	Gene:	Kdr / 25589	RGDID:	2965	Length:	1343	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	221/907 - (24%)
Similarity:	361/907 - (39%)	Gaps:	286/907 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 VKDDNKETALYLSDDNFLILPGLESNST--------HNITAL----AMHGDG------SYSLIAK 163
            |||......:.::.:.:.::.|  .|.|        .|::||    |::..|      |:.:|..
  Rat   484 VKDFQGGNKIEVTKNQYALIEG--KNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRG 546

  Fly   164 DQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSY----STNSVN 224
            .:  .|:....||::..:|:||                   .:|:.|.:.::..|    ...||:
  Rat   547 PE--ITVQPATQPTEQESVSLL-------------------CTADRNTFENLTWYKLGSQATSVH 590

  Fly   225 MDEPLEVQFRDRKKLYR--------HTVDNL---------------------EFDKQYHVGVRTV 260
            |.|.|....::...|::        .|.|.|                     :..|:.|..|:.:
  Rat   591 MGESLTPVCKNLDALWKLNGTVFSNSTNDILIVAFQNASLQDQGNYVCSAQDKKTKKRHCLVKQL 655

  Fly   261 NIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALN------ITWAR 319
            .|:.|:      .|:...:.                ||.|.|..:.:..:...:      |||.:
  Rat   656 VILERM------APMITGNL----------------ENQTTTIGETIEVVCPTSGNPTPLITWFK 698

  Fly   320 PRYLPDNYTLHIFD---LFKGGTELNYTLDQNRSH----FYVPKITVLG-SHFEVHLVAQSAGGK 376
                 ||.|| :.|   :.|.|.. |.|:.:.|..    :......||| :..|...:.:.|
  Rat   699 -----DNETL-VEDSGIVLKDGNR-NLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGA--- 753

  Fly   377 NVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASE 441
                  .:|.:..|::..|..|..:.|.:     :|::...|..|.|..|::
  Rat   754 ------QEKTNLEVIILVGTAVIAMFFWL-----LLVIVLRTVKRANEGELK------------- 794

  Fly   442 FHLSLMDSSGLLVTLSANESLEVMDELEVEPHS----------VLLQDVLGEGAFGLVRR----G 492
                    :|.|..:...:.|.:.:..|..|:.          :.|...||.||||.|..    |
  Rat   795 --------TGYLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFG 851

  Fly   493 VYKK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCS 554
            :.|.   :.||||:||:.....:..|...|:::|..:|.|.|:|.::|..|:....:|:::|:|.
  Rat   852 IDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 916

  Fly   555 LGSLQNFL---REEW--------KFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNS 608
            .|:|..:|   |.|:        :||..::.:|     |.:||.:|           |::.|.:|
  Rat   917 FGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVG-----ELSVDLKR-----------RLDSITSS 965

  Fly   609 MLST----VEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPK 669
            ..|.    |||:|                            |.|:|
  Rat   966 QSSASSGFVEEKS----------------------------LSDVE------------------- 983

  Fly   670 RKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQ 734
                   ::::.::...|     |...|:..|                   .:.|||.||||||.
  Rat   984 -------EEEASEELYKD-----FLTLEHLIC-------------------YSFQVAKGMEFLAS 1017

  Fly   735 NKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVY-RKSGGSGKLPIKWLALESLTHQVYTS 798
            .|.:||||||||:|:|....:||.||||:||:|.:..| ||  |..:||:||:|.|::..:|||.
  Rat  1018 RKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK--GDARLPLKWMAPETIFDRVYTI 1080

  Fly   799 QSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSH 862
            |||||||||||:||.:||..|||.|. ..:..:.|::|.||:.|:..|.||:..|..||...|:.
  Rat  1081 QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQ 1145

  Fly   863 RPTFSALKHRLGGMILAT--NDVPERLKQLQAATESKLKSCDGLNSKVEQVPC-EEELYLEP 921
            ||.||.|...||.::.|.  .|..:.:....:.|.| ::...||:.....|.| |||...:|
  Rat  1146 RPAFSELVEHLGNLLQANAQQDGKDYIVLPMSETLS-MEEDSGLSLPTSPVSCMEEEEVCDP 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	15/94 (16%)
		STYKc	475..873	CDD:214568	133/421 (32%)
		PTKc	479..873	CDD:270623	132/417 (32%)
Kdr	NP_037194.2	Ig	224..325	CDD:416386
		Ig strand A	224..228	CDD:409353
		Ig strand A'	234..238	CDD:409353
		Ig strand B	240..249	CDD:409353
		Ig strand C	256..261	CDD:409353
		Ig strand C'	264..266	CDD:409353
		Ig strand D	270..278	CDD:409353
		Ig strand E	286..294	CDD:409353
		Ig strand F	304..310	CDD:409353
		Ig strand G	315..321	CDD:409353
		Ig	329..417	CDD:416386
		Ig strand A	329..332	CDD:409353
		Ig strand A'	339..343	CDD:409353
		Ig strand B	345..356	CDD:409353
		Ig strand C	360..366	CDD:409353
		Ig strand C'	368..371	CDD:409353
		Ig strand D	376..379	CDD:409353
		Ig strand E	381..386	CDD:409353
		Ig strand F	394..402	CDD:409353
		Ig strand G	408..417	CDD:409353
		Ig_3	547..641	CDD:404760	18/114 (16%)
		IGc2	676..740	CDD:197706	14/70 (20%)
		Ig strand B	680..684	CDD:409353	0/3 (0%)
		Ig strand C	693..697	CDD:409353	2/3 (67%)
		Ig strand E	716..720	CDD:409353	1/4 (25%)
		Ig strand F	730..735	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	755..789	CDD:375470	8/38 (21%)
		PTKc_VEGFR2	822..1163	CDD:270681	135/436 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1314
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910