DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tor and FLT4

DIOPT Version :10

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:XP_011532780.1 Gene:FLT4 / 2324 HGNCID:3767 Length:1440 Species:Homo sapiens


Alignment Length:859 Identity:220/859 - (25%)
Similarity:337/859 - (39%) Gaps:239/859 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 RGYQPSKMGAVNLLR------FVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLE 230
            |.:.|.||.|...||      .:||..|...:..:....|....:.:.:.|.....:|:   .|.
Human   538 RPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVS---KLV 599

  Fly   231 VQFRDRKKLYRHTVDNL--EFDKQYHVGVRTVNIMNRLESD-----LQWLPIAVPSC-------- 280
            :|..:...:|:..|.|.  :.::..:..|.|:.....:||.     |:..|:.: ||        
Human   600 IQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLL-SCQADSYKYE 663

  Fly   281 -LDWYPYNY-TLCPPH--------KPENLTVTQ-----KQYLPNILALNITWARPRYLPD---NY 327
             |.||..|. ||...|        |..:|..|.     ::..|......::.:.||..|:   :|
Human   664 HLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHY 728

  Fly   328 TLHIFDLFKGGTELNYTLDQNRSH-------------FYVPKIT-------------------VL 360
            ...:.|              .|||             ...|::|                   |.
Human   729 VCEVQD--------------RRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVA 779

  Fly   361 GSH---------------------------FEVHLVAQSAGGK------NVSGLTLDKVHRGVLL 392
            |:|                           ..:..|.:...|:      |..|.........|..
Human   780 GAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEG 844

  Fly   393 SE--GNMVKLVLF---IIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGL 452
            ||  |:|..::|.   :|.....:|:|  |.||...|    ....|.|..     :||::...| 
Human   845 SEDKGSMEIVILVGTGVIAVFFWVLLL--LIFCNMRR----PAHADIKTG-----YLSIIMDPG- 897

  Fly   453 LVTLSANESLEVM----DELEVEPHSVLLQDVLGEGAFGLVRR----GVYKKRQ---VAVKLLKD 506
              .:...|..|.:    .:.|.....:.|..|||.||||.|..    |::|...   ||||:||:
Human   898 --EVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKE 960

  Fly   507 EPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQE 571
            .....:..|...|:::|..:|.|.|:|.::|..|:....:|:::|:|..|:|.||||.    :::
Human   961 GATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRA----KRD 1021

  Fly   572 QNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRIT 636
            ..:...:|:.||   ..||..:...:..||            .....||:...:|   ::.|.  
Human  1022 AFSPCAEKSPEQ---RGRFRAMVELARLDR------------RRPGSSDRVLFAR---FSKTE-- 1066

  Fly   637 NAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDC 701
                            ||:                .:..|.::::..:.|               
Human  1067 ----------------GGA----------------RRASPDQEAEDLWLS--------------- 1084

  Fly   702 LDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDV 766
                      ||...||:..:.|||.||||||..|.:||||||||:|:|....:||.||||:||:
Human  1085 ----------PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI 1139

  Fly   767 YHENVY-RKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLL 829
            |.:..| ||  ||.:||:||:|.||:..:|||:|||||||||||:||.:||..|||.|. ..:..
Human  1140 YKDPDYVRK--GSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFC 1202

  Fly   830 QLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQLQAAT 894
            |.||.|.||:.||..|..:..:|.:|||..|..||.||.|...||.::.......|  :::..|.
Human  1203 QRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEE--EEVCMAP 1265

  Fly   895 ESKLKSCDGLNSKV 908
            .|...|.:|..|:|
Human  1266 RSSQSSEEGSFSQV 1279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 PTKc 479..873 CDD:270623 135/402 (34%)
FLT4XP_011532780.1 Ig_2 214..301 CDD:464026
IgI_VEGFR 307..406 CDD:409448
Ig strand A 307..311 CDD:409448
Ig strand A' 317..321 CDD:409448
Ig strand B 323..332 CDD:409448
Ig strand C 339..344 CDD:409448
Ig strand C' 347..349 CDD:409448
Ig strand D 353..361 CDD:409448
Ig strand E 366..374 CDD:409448
Ig strand F 384..390 CDD:409448
Ig strand G 395..401 CDD:409448
IgI_VEGFR-3 408..495 CDD:409449
Ig strand A 409..414 CDD:409449
Ig strand A' 419..424 CDD:409449
Ig strand B 426..437 CDD:409449
Ig strand C 441..447 CDD:409449
Ig strand C' 449..452 CDD:409449
Ig strand D 455..457 CDD:409449
Ig strand E 459..464 CDD:409449
Ig strand F 472..480 CDD:409449
Ig strand G 486..495 CDD:409449
Ig_3 636..732 CDD:464046 21/96 (22%)
Ig 755..842 CDD:472250 9/86 (10%)
Ig strand B 772..776 CDD:409353 0/3 (0%)
Ig strand C 785..789 CDD:409353 0/3 (0%)
Ig strand E 808..812 CDD:409353 0/3 (0%)
Ig strand F 822..827 CDD:409353 0/4 (0%)
VEGFR-2_TMD 847..881 CDD:375470 10/39 (26%)
PTKc_VEGFR3 914..1253 CDD:270680 139/421 (33%)
Blue background indicates that the domain is not in the aligned region.

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