DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tor and FLT3

DIOPT Version :10

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_004110.2 Gene:FLT3 / 2322 HGNCID:3765 Length:993 Species:Homo sapiens


Alignment Length:943 Identity:232/943 - (24%)
Similarity:372/943 - (39%) Gaps:250/943 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 CLEKGQMDFRSCLKDCRINGTFPGALRK----VQENYQMNMICRTESEI------VFQIDWVQHS 99
            |..:|:    ||.::.      |..::|    :.|.:..::.|...:|:      :|.||..|..
Human   199 CDSQGE----SCKEES------PAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTP 253

  Fly   100 RGTEP----APNATYIIRVDAV----------KDDNKETALYLSDDNFLILPGLESNSTHNITAL 150
            :.|.|    .......||..||          :.:||.    |.:.|:..:....:|.|......
Human   254 QTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKA----LEEGNYFEMSTYSTNRTMIRILF 314

  Fly   151 AMHGDGSYSLIAKDQT-FATLIRGYQPSKMGAVNLLR--FVP--------QPDDLHHIAAEIEWK 204
            |.     .|.:|::.| :.|......||:...|.::.  |:.        :.|........:.:|
Human   315 AF-----VSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFK 374

  Fly   205 PSAESNC--YFDMVSYSTNSVNMDEPLEV-QFRDRKK-----LYRHTVDNLEFDKQYHVGVRTVN 261
            ...:..|  .|...|:......:|....: :|.:.|.     ::....|:.:|.|.:.:.:|   
Human   375 AYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIR--- 436

  Fly   262 IMNRLESDLQWLPIAVPSCL-DWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPD 325
               |....|.....:..||. |.||                     ||     :.||.:......
Human   437 ---RKPQVLAEASASQASCFSDGYP---------------------LP-----SWTWKKCSDKSP 472

  Fly   326 NYTLHIFDLFKGGTELNYTLDQNRSHF--YVPKITVLGSH----FEVHLVAQSAGGKNVSGLTLD 384
            |.|..|       ||..:....||..|  :|...|:..|.    |.|...|.::.|.:...:.|:
Human   473 NCTEEI-------TEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLN 530

  Fly   385 KVHRGVLLSEGNMVKLVLFIIVPICCI-LMLCSLTFCR------RNRSEVQALQMDAKDAKASEF 442
            .......:.:    .:..:..:.:|.: :::.:|..|.      |..|::|.:|           
Human   531 SPGPFPFIQD----NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQ----------- 580

  Fly   443 HLSLMDSSGLLVTLSANESLEVMDELEVE-------PHSVL-LQDVLGEGAFGLVRR----GVYK 495
                       ||.|::.....:|..|.|       |...| ...|||.||||.|..    |:.|
Human   581 -----------VTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISK 634

  Fly   496 ---KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGS 557
               ..|||||:||::.:..:..|...|::|:..:|.|.|||.::|..| .|..:.|:.|||..|.
Human   635 TGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT-LSGPIYLIFEYCCYGD 698

  Fly   558 LQNFLR-EEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQ 621
            |.|:|| :..||.:....|..:.|         |:..|....|.     |:||..:.|.:...|.
Human   699 LLNYLRSKREKFHRTWTEIFKEHN---------FSFYPTFQSHP-----NSSMPGSREVQIHPDS 749

  Fly   622 THSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKS 686
            ...|                   ||.     |.|:                      .|:.:.:.
Human   750 DQIS-------------------GLH-----GNSF----------------------HSEDEIEY 768

  Fly   687 DNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISV 751
            :|:||:.|.::.            ..|.:.|||..|.|||.|||||.....|||||||||||::.
Human   769 ENQKRLEEEEDL------------NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 821

  Fly   752 DRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLG 816
            .:.:||.||||:||:..::.| ...|:.:||:||:|.|||...:||.:|||||:|:||:||.:||
Human   822 GKVVKICDFGLARDIMSDSNY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG 885

  Fly   817 GMPYPSVSPSD--LLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879
            ..|||.: |.|  ..:|::.|.:|.:|...|:|::.:|:|||:.....||:|..|...||     
Human   886 VNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLG----- 944

  Fly   880 TNDVPERLKQLQAATESKLKSCDGLNSKVEQVP 912
                    .||..|.|:..::.||   :|.:.|
Human   945 --------CQLADAEEAMYQNVDG---RVSECP 966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 PTKc 479..873 CDD:270623 134/403 (33%)
FLT3NP_004110.2 ig 256..345 CDD:395002 20/97 (21%)
Ig strand B 268..272 CDD:409448 1/3 (33%)
Ig strand C 282..286 CDD:409448 0/3 (0%)
Ig strand E 314..317 CDD:409448 1/7 (14%)
Ig strand F 327..332 CDD:409448 1/4 (25%)
Ig strand G 340..343 CDD:409448 0/2 (0%)
Protein Kinases, catalytic domain 572..947 CDD:473864 147/484 (30%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand 591..597 1/5 (20%)

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