DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tor and FLT3

DIOPT Version :9

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_004110.2 Gene:FLT3 / 2322 HGNCID:3765 Length:993 Species:Homo sapiens


Alignment Length:943 Identity:232/943 - (24%)
Similarity:372/943 - (39%) Gaps:250/943 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 CLEKGQMDFRSCLKDCRINGTFPGALRK----VQENYQMNMICRTESEI------VFQIDWVQHS 99
            |..:|:    ||.::.      |..::|    :.|.:..::.|...:|:      :|.||..|..
Human   199 CDSQGE----SCKEES------PAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTP 253

  Fly   100 RGTEP----APNATYIIRVDAV----------KDDNKETALYLSDDNFLILPGLESNSTHNITAL 150
            :.|.|    .......||..||          :.:||.    |.:.|:..:....:|.|......
Human   254 QTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKA----LEEGNYFEMSTYSTNRTMIRILF 314

  Fly   151 AMHGDGSYSLIAKDQT-FATLIRGYQPSKMGAVNLLR--FVP--------QPDDLHHIAAEIEWK 204
            |.     .|.:|::.| :.|......||:...|.::.  |:.        :.|........:.:|
Human   315 AF-----VSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFK 374

  Fly   205 PSAESNC--YFDMVSYSTNSVNMDEPLEV-QFRDRKK-----LYRHTVDNLEFDKQYHVGVRTVN 261
            ...:..|  .|...|:......:|....: :|.:.|.     ::....|:.:|.|.:.:.:|   
Human   375 AYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIR--- 436

  Fly   262 IMNRLESDLQWLPIAVPSCL-DWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPD 325
               |....|.....:..||. |.||                     ||     :.||.:......
Human   437 ---RKPQVLAEASASQASCFSDGYP---------------------LP-----SWTWKKCSDKSP 472

  Fly   326 NYTLHIFDLFKGGTELNYTLDQNRSHF--YVPKITVLGSH----FEVHLVAQSAGGKNVSGLTLD 384
            |.|..|       ||..:....||..|  :|...|:..|.    |.|...|.::.|.:...:.|:
Human   473 NCTEEI-------TEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLN 530

  Fly   385 KVHRGVLLSEGNMVKLVLFIIVPICCI-LMLCSLTFCR------RNRSEVQALQMDAKDAKASEF 442
            .......:.:    .:..:..:.:|.: :::.:|..|.      |..|::|.:|           
Human   531 SPGPFPFIQD----NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQ----------- 580

  Fly   443 HLSLMDSSGLLVTLSANESLEVMDELEVE-------PHSVL-LQDVLGEGAFGLVRR----GVYK 495
                       ||.|::.....:|..|.|       |...| ...|||.||||.|..    |:.|
Human   581 -----------VTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISK 634

  Fly   496 ---KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGS 557
               ..|||||:||::.:..:..|...|::|:..:|.|.|||.::|..| .|..:.|:.|||..|.
Human   635 TGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT-LSGPIYLIFEYCCYGD 698

  Fly   558 LQNFLR-EEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQ 621
            |.|:|| :..||.:....|..:.|         |:..|....|.     |:||..:.|.:...|.
Human   699 LLNYLRSKREKFHRTWTEIFKEHN---------FSFYPTFQSHP-----NSSMPGSREVQIHPDS 749

  Fly   622 THSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKS 686
            ...|                   ||.     |.|:                      .|:.:.:.
Human   750 DQIS-------------------GLH-----GNSF----------------------HSEDEIEY 768

  Fly   687 DNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISV 751
            :|:||:.|.::.            ..|.:.|||..|.|||.|||||.....|||||||||||::.
Human   769 ENQKRLEEEEDL------------NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 821

  Fly   752 DRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLG 816
            .:.:||.||||:||:..::.| ...|:.:||:||:|.|||...:||.:|||||:|:||:||.:||
Human   822 GKVVKICDFGLARDIMSDSNY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG 885

  Fly   817 GMPYPSVSPSD--LLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879
            ..|||.: |.|  ..:|::.|.:|.:|...|:|::.:|:|||:.....||:|..|...||     
Human   886 VNPYPGI-PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLG----- 944

  Fly   880 TNDVPERLKQLQAATESKLKSCDGLNSKVEQVP 912
                    .||..|.|:..::.||   :|.:.|
Human   945 --------CQLADAEEAMYQNVDG---RVSECP 966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 FN3 199..261 CDD:214495 11/69 (16%)
STYKc 475..873 CDD:214568 135/408 (33%)
PTKc 479..873 CDD:270623 134/403 (33%)
FLT3NP_004110.2 ig 256..345 CDD:278476 20/97 (21%)
PKc_like 572..947 CDD:304357 147/484 (30%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand 591..597 1/5 (20%)
Pkinase_Tyr 610..943 CDD:285015 135/407 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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