DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and FLT1

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_002010.2	Gene:	FLT1 / 2321	HGNCID:	3763	Length:	1338	Species:	Homo sapiens

Alignment Length:	1007	Identity:	235/1007 - (23%)
Similarity:	383/1007 - (38%)	Gaps:	333/1007 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HDKTLLNVTACTQNCLEKGQMDFRSCLKDCRINGTFPGALRKVQENYQMNMICRT--ESEIVFQI 93
            :||..:.|....|..||                 |..|     :.:|:::|..:.  ..|:|:..
Human   329 YDKAFITVKHRKQQVLE-----------------TVAG-----KRSYRLSMKVKAFPSPEVVWLK 371

  Fly    94 DWVQHSRGTEPA--PNATYIIRVDA--VKDDNKETALYLSDDNFLILPGL-ESNSTHNITALAMH 153
            |.:       ||  .:|.|:.|..:  :||..:|.|     .|:.||..: :||...|:||
Human   372 DGL-------PATEKSARYLTRGYSLIIKDVTEEDA-----GNYTILLSIKQSNVFKNLTA---- 420

  Fly   154 GDGSYSLI--AKDQTFATLIRGY-QPS--KMGAVNLLRF----VPQPD--------DLHHIAAEI 201
                 :||  .|.|.:...:..: .|:  .:|:..:|..    :|||.        :.:|..|..
Human   421 -----TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480

  Fly   202 EWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTV---------------------- 244
            ::..:.|.:...|..|...|.:............:.|:....|
Human   481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVG 545

  Fly   245 DNLEF-----DKQYHVGVR-------------TVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLC 291
            .|:.|     ...:||.:.             |||  ..|..|:.|:.:...:       |.|:.
Human   546 RNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVN--KFLYRDVTWILLRTVN-------NRTMH 601

  Fly   292 PPHKPENLTVTQKQYLP-NILALNI------TWA-RPR----------------------YLPDN 326
            .....:.:.:|::..:. |:..:|:      |:| |.|                      ||..|
Human   602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRN 666

  Fly   327 YTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAG---GKNVSGLTLDKV-- 386
            .:.|...:     ..:.|||.:.:....|:||...::   |.:.|..|   |...|.|.:::|
Human   667 LSDHTVAI-----SSSTTLDCHANGVPEPQITWFKNN---HKIQQEPGIILGPGSSTLFIERVTE 723

  Fly   387 -HRGV-----------------LLSEGNMVKLVLFIIVPIC-CI-------LMLCSLTFCRRNRS 425
             ..||                 |..:|...|..|.:|...| |:       |:...:...:|:.|
Human   724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSS 788

  Fly   426 EVQ----ALQMDAK-------------DAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPH 473
            |::    ::.||..             ||...||               |.|.|:
Human   789 EIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEF---------------ARERLK---------- 828

  Fly   474 SVLLQDVLGEGAFGLVRR----GVYKK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPN 531
               |...||.||||.|.:    |:.|.   |.||||:||:.....:..|...|:::|..:|.|.|
Human   829 ---LGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLN 890

  Fly   532 IVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRN 596
            :|.::|..|:....:|:::|||..|:|.|:|:.             |::|
Human   891 VVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKS-------------KRDL--------------- 927

  Fly   597 SIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTA 661
                                                                      .::.|.|
Human   928 ----------------------------------------------------------FFLNKDA 934

  Fly   662 EAPKDRPKRKLKP------QPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKP--RIPLKYADL 718
            ....:..|.|::|      :|:.||....:|.......|:|...|..:..|:..  :.|:...||
Human   935 ALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDL 999

  Fly   719 LDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPI 783
            :..:.|||.|||||:..|.:||||||||:|:|.:..:||.||||:||:|....|.:.|.: :||:
Human  1000 ISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDT-RLPL 1063

  Fly   784 KWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQE 847
            ||:|.||:..::|:::|||||:||||:||.:|||.|||.|. ..|....||:|.||:.||..|.|
Human  1064 KWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPE 1128

  Fly   848 MFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879
            ::.:|..||...|..||.|:.|..:||.::.|
Human  1129 IYQIMLDCWHRDPKERPRFAELVEKLGDLLQA 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	12/101 (12%)
		STYKc	475..873	CDD:214568	126/413 (31%)
		PTKc	479..873	CDD:270623	125/409 (31%)
FLT1	NP_002010.2	IG_like	143..219	CDD:214653
		IG_like	237..328	CDD:214653
		Ig1_VEGFR_like	245..327	CDD:143219
		Ig2_VEGFR-1	353..424	CDD:143326	23/91 (25%)
		IG	568..640	CDD:214652	14/80 (18%)
		IGc2	569..640	CDD:197706	14/79 (18%)
		I-set	661..748	CDD:254352	20/94 (21%)
		IGc2	676..738	CDD:197706	15/64 (23%)
		PTKc_VEGFR1	819..1157	CDD:271109	133/452 (29%)
		Pkinase_Tyr	827..1154	CDD:285015	127/426 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..982		10/41 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910