DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and FGFR2

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens

Alignment Length:	820	Identity:	198/820 - (24%)
Similarity:	323/820 - (39%)	Gaps:	292/820 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 YSTNSVNMDEPLE-------VQFR-----DRKKLYRHTVDNLEFDKQYHVG---VRTVNIMNRLE 267
            |.||:..|::.|.       |:||     :.....|...:..||.:::.:|   ||..:....:|
Human   174 YWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIME 238

  Fly   268 SDLQWLPIAVPS------CL---DWYPYNYTL------CPPHKPENLTVTQKQYLPNILAL---- 313
            |       .|||      |:   ::...|:|.      ..||:|    :.|.....|...:
Human   239 S-------VVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRP----ILQAGLPANASTVVGGD 292

  Fly   314 -------------NITWAR------PRYLPDNY-----------------TLHIFDLFKGGTEL- 341
                         :|.|.:      .:|.||..                 .|.:|::    ||.
Human   293 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV----TEAD 353

  Fly   342 ---------NYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNM 397
                     ||....|:|.:    :|||..        |.|.|:...           :.:..:.
Human   354 AGEYICKVSNYIGQANQSAW----LTVLPK--------QQAPGREKE-----------ITASPDY 395

  Fly   398 VKLVLFIIVPICCILMLCSLTFCR-RNRSE---------VQAL--------QMDAKDAKASEFHL 444
            :::.::.|.......|:.::..|| :|.::         |..|        |:.|:.:.:...:.
Human   396 LEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNT 460

  Fly   445 SLMDSSGLLVTLSANESLEVMDELEV--EP------HSVLLQDVLGEGAFGLV----RRGVYKKR 497
            .|:..:..|.:.:....|..:.|.|:  :|      ..:.|...||||.||.|    ..|:.|.:
Human   461 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 525

  Fly   498 -----QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGS 557
                 .||||:|||:..::|:.....|::|:|.:|||.||:.::|..|: ...:.:::||.|.|:
Human   526 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGN 589

  Fly   558 LQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQT 622
            |:.:||..           ....:|.:.|   .||:|                   ||:
Human   590 LREYLRAR-----------RPPGMEYSYD---INRVP-------------------EEQ------ 615

  Fly   623 HSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSD 687

Human   616 ----------------------------------------------------------------- 615

  Fly   688 NKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVD 752
                                     :.:.||:....|:|.|||:||..|.:||||||||||::.:
Human   616 -------------------------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 655

  Fly   753 RSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGG 817
            ..:|||||||:||:.:.:.|:|: .:|:||:||:|.|:|..:|||.||||||||||::||.||||
Human   656 NVMKIADFGLARDINNIDYYKKT-TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 719

  Fly   818 MPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI-LATN 881
            .|||.:...:|.:||::||||.:|..||.|::.:|..||.:|||.||||..|...|..:: |.||
Human   720 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 784

  Fly   882 ----DVPERLKQLQAATESKLKSCDGLNSKV---EQVPCE 914
                |:.:.|:|...:......||...:..|   :.:|.|
Human   785 EEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYE 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	14/57 (25%)
		STYKc	475..873	CDD:214568	125/406 (31%)
		PTKc	479..873	CDD:270623	124/402 (31%)
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174
		IG_like	66..143	CDD:214653
		Ig2_FGFR	183..267	CDD:143265	18/90 (20%)
		IG_like	282..376	CDD:214653	14/101 (14%)
		Ig3_FGFR	290..377	CDD:143175	14/94 (15%)
		PTKc_FGFR2	474..786	CDD:270679	133/442 (30%)
		Pkinase_Tyr	499..775	CDD:285015	125/406 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910