Protein Alignment tor and FGFR1

DIOPT Version :9

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: XP_011542745.1
• Gene: FGFR1 / 2260
• HGNCID: 3688
• Length: 865
• Species: Homo sapiens
• Alignment Length: 932
• Identity: 228/932 - (24%)
• Similarity: 348/932 - (37%)
• Gaps: 323/932 - (34%)

  Fly   131 DNFLILPG----LESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQP 191
            ::||:.||    |......::.::....||    :...::..|.|.|.:      |.:...||..
Human    74 ESFLVHPGDLLQLRCRLRDDVQSINWLRDG----VQLAESNRTRITGEE------VEVQDSVPAD 128

  Fly   192 DDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVG 256
            ..|:   |.:...||.....||        |||:.:.|.           .:.|:.:.|......
Human   129 SGLY---ACVTSSPSGSDTTYF--------SVNVSDALP-----------SSEDDDDDDDSSSEE 171

  Fly   257 VRTVNIM-NRLESDLQWL-PIAVPSCLDWYPYNYTL---CPPHKPENLTV----TQKQYLPN--I 310
            ..|.|.. ||:.....|. |..:...|...|...|:   ||.....|.|:    ..|::.|:  |
Human   172 KETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 236

  Fly   311 LALNITWARPRYLPD--------NYTLHIFDLFKGGTELNYTLDQNRSHFYVP---------KIT 358
            ....:.:|....:.|        |||..:.:.: |.....|.||......:.|         |..
Human   237 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEY-GSINHTYQLDVVERSPHRPILQAGLPANKTV 300

  Fly   359 VLGS--------------------HFEV-----------HLVAQSAGGKNVSGLTLDKVH-RGVL 391
            .|||                    |.||           ::......|.|.:...::.:| |.|.
Human   301 ALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVS 365

  Fly   392 LSE--------GNMVKL----------------------VLFIIVPICC---ILMLCSLTFCRRN 423
            ..:        ||.:.|                      .|::.:.|.|   .|:.|.:
Human   366 FEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV------ 424

  Fly   424 RSEVQALQMDAKDAKASEFHLSL------------------------MDSSGLLV-----TLSAN 459
             ..|...:|.: ..|.|:||..:                        |:|..|||     :.|..
Human   425 -GSVIVYKMKS-GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGT 487

  Fly   460 ESLEVMDELEV--EPHSVLLQD------VLGEGAFGLV----RRGVYKKR-----QVAVKLLKDE 507
            ..|..:.|.|:  :|...|.:|      .||||.||.|    ..|:.|.:     :||||:||.:
Human   488 PMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 552

  Fly   508 PNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQ 572
            ..::|:.....|::|:|.:|||.||:.::|..|: ...:.:::||.|.|:|:.:|:.
Human   553 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQA-------- 608

  Fly   573 NAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITN 637
                              .|.|
Human   609 ------------------RRPP------------------------------------------- 612

  Fly   638 AADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCL 702
                   |||...|            |...|:.:|..:
Human   613 -------GLEYCYN------------PSHNPEEQLSSK--------------------------- 631

  Fly   703 DSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVY 767
                          ||:..|.|||.|||:||..|.:||||||||||::.|..:|||||||:||::
Human   632 --------------DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 682

  Fly   768 HENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLL 832
            |.:.|:|: .:|:||:||:|.|:|..::||.|||||||||||:||.||||.|||.|...:|.:||
Human   683 HIDYYKKT-TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 746

  Fly   833 RQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATN------DVPERLKQLQ 891
            ::||||.:|..||.|::.:|..||.:|||.||||..|...|..::..|:      |:...|..|:
Human   747 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQVLHPDLTTHLLPLR 811

  Fly   892 AATESKLKSCDGLNSKVEQVPC 913
            ...:.:.:.|  |....|..||
Human   812 CFWKVRKRRC--LLRGQEPHPC 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	12/61 (20%)
		STYKc	475..873	CDD:214568	131/412 (32%)
		PTKc	479..873	CDD:270623	130/408 (32%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	21/97 (22%)
		IG_like	77..151	CDD:214653	20/94 (21%)
		I-set	193..280	CDD:254352	18/87 (21%)
		Ig2_FGFR	196..280	CDD:143265	18/84 (21%)
		IG_like	295..391	CDD:214653	15/95 (16%)
		Ig3_FGFR	303..392	CDD:143175	13/88 (15%)
		PTKc_FGFR1	497..797	CDD:270678	135/430 (31%)
		Pkinase_Tyr	511..787	CDD:285015	129/406 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910