DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Tie1

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_035717.2	Gene:	Tie1 / 21846	MGIID:	99906	Length:	1134	Species:	Mus musculus

Alignment Length:	970	Identity:	217/970 - (22%)
Similarity:	348/970 - (35%)	Gaps:	321/970 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DCRI-----NG----TFPGAL-------RKVQENYQMNMICRTESEIVFQIDWVQHSRGTEP--- 104
            |||:     ||    .|.|.:       ...:::.::..|....:|:.|.|       ||.|
Mouse   312 DCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILSMATEVEFNI-------GTMPRIN 369

  Fly   105 -----------------APNATYIIRVDAVKDDNKETA------LYLSDDNF------------- 133
                             .|:.|.::....:.:.::.||      |.|.|..|
Mouse   370 CAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDS 434

  Fly   134 -------------LILPGLESNSTHNITA---LAMHGDGSYSLI-----AKDQTFATLIRGYQPS 177
                         |..|.|.:..:..:..   ::..|||..|.:     .:|.|.|.......||
Mouse   435 RRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPS 499

  Fly   178 KMGAVNLLRFVPQPDDLHHIAAEIE---------WKPSA--ESNCYFDM---------------- 215
            :  .|.|:...|:..  :::..::.         |.|||  .::|...:
Mouse   500 E--NVTLMNLKPKTG--YNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRL 560

  Fly   216 -VSYSTNSVNMDEPLE-----------VQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLES 268
             ||:|..||    ||.           .:.::|:       :|:.|.:     .||. ::..|..
Mouse   561 RVSWSLPSV----PLSGDGFLLRLWDGARGQERR-------ENISFPQ-----ARTA-LLTGLTP 608

  Fly   269 DLQWLPIAVPSCLDWYPYNYTLCPP-------HKPENLTVTQKQYLPNILA---LNITWARPRYL 323
            ...:.       ||...|:.||..|       |.|.:.....:......|:   :.:.|..|...
Mouse   609 GTHYQ-------LDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAP 666

  Fly   324 PDNYTLHIFDL-FKGGTELNYTLDQNRSHFYVPKITVLGSH------FEVHLVAQSAG--GKNVS 379
            ....:.:|.:: ..||:.....:|.:|..  ...|.|.|.:      |.|....|..|  ...|.
Mouse   667 SGPISKYIVEIQVAGGSGDPQWMDVDRPE--ETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVE 729

  Fly   380 GLTLDK-------VHRGVLLSEGNMVKLVLFII--VPICCILMLCSL--TFCRRNRSEVQALQMD 433
            ..||..       |.......||...:|||.::  |...|:.:|.:|  ..|.| ||.:...:..
Mouse   730 EATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIR-RSCLHRRRTF 793

  Fly   434 AKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYK--- 495
            ...:.:.|..:....|..|.:|.......|.:....:|...:..:|::|||.||.|.|.:.|
Mouse   794 TYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDG 858

  Fly   496 -KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQ 559
             |...|:|:||:..::.|...|..|:::|..:|.||||:.::| :......:.:.|||...|:|.
Mouse   859 LKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLG-ACENRGYLYIAIEYAPYGNLL 922

  Fly   560 NFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHS 624
            :|||
Mouse   923 DFLR------------------------------------------------------------- 926

  Fly   625 SRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNK 689
                                                                            |
Mouse   927 ----------------------------------------------------------------K 927

  Fly   690 KRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRS 754
            .|:.|....|    :.:......|....||..|...|.||::|::.:.:||||||||||:..:.:
Mouse   928 SRVLETDPAF----AREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLA 988

  Fly   755 IKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMP 819
            .|||||||||.   |.||.|. ..|:||::|:|:|||.:.|||::||||||||||:||.:|||.|
Mouse   989 SKIADFGLSRG---EEVYVKK-TMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP 1049

  Fly   820 YPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879
            |..::.::|.:.|.||:||::|..|..|::.||..||...|..||.|:.:..:||.|:.|
Mouse  1050 YCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	17/100 (17%)
		STYKc	475..873	CDD:214568	112/401 (28%)
		PTKc	479..873	CDD:270623	112/397 (28%)
Tie1	NP_035717.2	ig	127..208	CDD:278476
		IG_like	131..210	CDD:214653
		EGF_Lam	225..263	CDD:238012
		EGF_CA	312..343	CDD:238011	7/30 (23%)
		ig	353..439	CDD:278476	14/92 (15%)
		IG	367..441	CDD:214652	8/73 (11%)
		fn3	447..518	CDD:278470	15/74 (20%)
		fn3	546..628	CDD:278470	19/105 (18%)
		FN3	640..732	CDD:238020	16/93 (17%)
		PTKc_Tie1	832..1128	CDD:270671	116/412 (28%)
		TyrKc	835..1103	CDD:197581	112/401 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100