DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Tek

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus

Alignment Length:	779	Identity:	185/779 - (23%)
Similarity:	304/779 - (39%)	Gaps:	228/779 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LESNSTHNI-TALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIE 202
            ||..:.:.: ..||..|:|........:.|.|...|..|.:.     |..:|:    ...|..:.
Mouse   505 LEPRTDYELCVQLARPGEGGEGHPGPVRRFTTASIGLPPPRG-----LSLLPK----SQTALNLT 560

  Fly   203 WKP---SAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMN 264
            |:|   ::|...|.::...|..:.:..:.::|.    ..|....:.||...:||.|..| ||...
Mouse   561 WQPIFTNSEDEFYVEVERRSLQTTSDQQNIKVP----GNLTSVLLSNLVPREQYTVRAR-VNTKA 620

  Fly   265 RLE--SDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNY 327
            :.|  .:|:...::            .:.|| :|||:.::.   :.:..|: ::|.    :.|.|
Mouse   621 QGEWSEELRAWTLS------------DILPP-QPENIKISN---ITDSTAM-VSWT----IVDGY 664

  Fly   328 TL----------------HIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGK 376
            ::                ||....|..|...|.|..     ..|:.|     :.|.:.|::..|.
Mouse   665 SISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLKG-----LEPETT-----YHVDIFAENNIGS 719

  Fly   377 NVSGL-----TLDKVHRGVLLSEGNMVKLVLFIIVPICCI-LMLCSLTFCRRNRSEVQALQMDA- 434
            :....     ||........|..|.|:.:.:.....:.|| ::|..|...:..|:.||.....|
Mouse   720 SNPAFSHELRTLPHSPASADLGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAF 784

  Fly   435 ---KDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEP----HSVLLQDVLGEGAFGLVRRG 492
               ::..|.:|      :||   ||:.|...:...:..:.|    :.:..|||:|||.||.|.:.
Mouse   785 QNVREEPAVQF------NSG---TLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKA 840

  Fly   493 VYKK----RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYC 553
            ..||    ...|:|.:|:..:.:|...|..|:::|..:|.||||:.::| :......:.|.|||.
Mouse   841 RIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLG-ACEHRGYLYLAIEYA 904

  Fly   554 SLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESE 618
            ..|:|.:|||
Mouse   905 PHGNLLDFLR------------------------------------------------------- 914

  Fly   619 SDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQD 683

Mouse   915 ----------------------------------------------------------------- 914

  Fly   684 FKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVL 748
                 |.|:.|....|...:|:.:    .|....||..|..||.||::|:|.:.:||||||||:|
Mouse   915 -----KSRVLETDPAFAIANSTAS----TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNIL 970

  Fly   749 ISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEIT 813
            :..:...|||||||||.   :.||.|. ..|:||::|:|:|||.:.|||:.|||||:||||:||.
Mouse   971 VGENYIAKIADFGLSRG---QEVYVKK-TMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIV 1031

  Fly   814 TLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI 877
            :|||.||..::.::|.:.|.||:|:::|..|..|::.||..||...|..||:|:.:...|..|:
Mouse  1032 SLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	13/64 (20%)
		STYKc	475..873	CDD:214568	112/401 (28%)
		PTKc	479..873	CDD:270623	111/397 (28%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		EGF_2	311..340	CDD:285248
		fn3	445..516	CDD:278470	2/10 (20%)
		fn3	542..625	CDD:278470	20/96 (21%)
		FN3	638..730	CDD:238020	20/110 (18%)
		PTKc_Tie2	815..1117	CDD:133219	115/415 (28%)
		STYKc	823..1091	CDD:214568	112/401 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100