DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001139740.1	Gene:	Pdgfrb / 18596	MGIID:	97531	Length:	1099	Species:	Mus musculus

Alignment Length:	937	Identity:	225/937 - (24%)
Similarity:	366/937 - (39%)	Gaps:	241/937 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LNVTA-CTQNCLEKGQMDFRSCLKDCRING--------TFP----GALRKVQENYQMNMICRTES 87
            :||:. ..|..:.:|:    |....|.:.|        |:|    |.|.:...:|...:..|..|
Mouse   213 INVSVNAVQTVVRQGE----SITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGS 273

  Fly    88 EIVFQIDWVQHSRGTEPAPNATYIIRVD-AVKDDNKETALYLSDDNFLILPGLESNSTHNITALA 151
                    :.|....|.:.:.||...|. :|.|...|.|:.:|    :|..|.       :..|.
Mouse   274 --------ILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINIS----VIENGY-------VRLLE 319

  Fly   152 MHGDGSYSLIAKDQTFATLIRGY-QPSKM-----------GAVNLLRFVPQPDDLHHIAAEIEWK 204
            ..||...:.:.:.:|...:...| .||.:           ||..|:.......:..:::..|..:
Mouse   320 TLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVR 384

  Fly   205 PSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESD 269
            .......|:.|.::       .|..|||              |.|..|.:|.||.:.:.   ||.
Mouse   385 VKVSEAGYYTMRAF-------HEDDEVQ--------------LSFKLQVNVPVRVLELS---ESH 425

  Fly   270 LQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDL 334
                                   |...|.....:.:.:|.   .|:||:..|.|.......:...
Mouse   426 -----------------------PANGEQTIRCRGRGMPQ---PNVTWSTCRDLKSRCPRKLSPT 464

  Fly   335 FKGGT-------ELNYTL---DQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTL---DKV 386
            ..|.:       |.|.|.   ||........::..:.....|..:.|::.|.:...:|:   ...
Mouse   465 PLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGGDSQEVTVVPHSLP 529

  Fly   387 HRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSG 451
            .:.|::|.  ::.||:..::.:..::||    :.::.|.|::...:::..:...|:  ..:|.
Mouse   530 FKVVVISA--ILALVVLTVISLIILIML----WQKKPRYEIRWKVIESVSSDGHEY--IYVDP-- 584

  Fly   452 LLVTLSANESLEV-MDELEVEPHSVLLQDVLGEGAFGLV----RRGVYKKR---QVAVKLLKDEP 508
              |.|..:.:.|: .|:|       :|...||.||||.|    ..|:...:   :||||:||...
Mouse   585 --VQLPYDSTWELPRDQL-------VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTA 640

  Fly   509 NDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFL-REEWKFRQEQ 572
            ...:..|...|::::..:|.|.|:|.::|..|: ...:.::.|||..|.|.::| |.:..|.|
Mouse   641 RSSEKQALMSELKIMSHLGPHLNVVNLLGACTK-GGPIYIITEYCRYGDLVDYLHRNKHTFLQ-- 702

  Fly   573 NAIGLKKNLEQNVDNRRFNR--LPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRI 635
                           |..|:  .|...::.....:..|:.|.:....|||
Mouse   703 ---------------RHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESD--------------- 737

  Fly   636 TNAADNKGY-GLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYF 699
                  .|| .:...|:|  .|:|..                      |.|.|.|....|:..|.
Mouse   738 ------GGYMDMSKDESI--DYVPML----------------------DMKGDIKYADIESPSYM 772

  Fly   700 DCLDSSDTKPRIP--------------LKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLIS 750
            ...|  :..|..|              |.|.||:..:.|||.||:|||....||||||||||||.
Mouse   773 APYD--NYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLIC 835

  Fly   751 VDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTL 815
            ..:.:||.||||:||:..::.| .|.||..||:||:|.||:.:.:||:.|||||||:||:||.||
Mouse   836 EGKLVKICDFGLARDIMRDSNY-ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL 899

  Fly   816 GGMPYPSVSPSD-LLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879
            ||.|||.:..:| ....:::|:||.:|...:.|::.:|:.||......||.||.|...|
Mouse   900 GGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL------ 958

  Fly   880 TNDVPERL------KQLQAATESKLKS 900
                 |||      |:.|...|..|:|
Mouse   959 -----ERLLGEGYKKKYQQVDEEFLRS 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	13/61 (21%)
		STYKc	475..873	CDD:214568	132/423 (31%)
		PTKc	479..873	CDD:270623	131/419 (31%)
Pdgfrb	NP_001139740.1	ig	36..113	CDD:278476
		IG_like	221..309	CDD:214653	22/103 (21%)
		Ig	227..311	CDD:299845	21/99 (21%)
		Ig	313..414	CDD:299845	21/128 (16%)
		IG	334..412	CDD:214652	16/98 (16%)
		PKc_like	562..953	CDD:304357	138/469 (29%)
		Pkinase_Tyr	600..953	CDD:285015	131/425 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1099
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5472
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960