Protein Alignment tor and Pdgfra

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_035188.2
• Gene: Pdgfra / 18595
• MGIID: 97530
• Length: 1089
• Species: Mus musculus
• Alignment Length: 1159
• Identity: 249/1159 - (21%)
• Similarity: 398/1159 - (34%)
• Gaps: 432/1159 - (37%)

  Fly    55 SCLKDCRINGTFPGAL---------------RKVQENYQMNMICRTESEIVFQIDWVQHSRGTEP 104
            |||.      |.||.:               :.||.|...::.|..|||    :.| ||....|.
Mouse    12 SCLL------TGPGLISCQLLLPSILPNENEKIVQLNSSFSLRCVGESE----VSW-QHPMSEED 65

  Fly   105 APNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAK-DQTFA 168
            .||.       .::.:...:.|:::     :|..:.:::.|.         |.|:.... .||..
Mouse    66 DPNV-------EIRSEENNSGLFVT-----VLEVVNASAAHT---------GWYTCYYNHTQTDE 109

  Fly   169 TLIRGYQPSKMGAVNLLRFVPQPD------DLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDE 227
            :.|.|.        ::..:||.||      .:......:|...||...|.           ..|.
Mouse   110 SEIEGR--------HIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCR-----------TTDP 155

  Fly   228 PLEVQFRDRKKLYRHTVD-----------------------------------------NLEFDK 251
            ..:|...:..:|...:.|                                         |||.|.
Mouse   156 ETQVTLHNNGRLVPASYDSRQGFNGTFSVGPYICEATVKGRTFKTSEFNVYALKATSELNLEMDA 220

  Fly   252 Q---YHVG---VRTVNIMNRLESDLQWL--------------PIAVPSCLDWYPYNYTLCPPH-- 294
            :   |..|   |.|..:.|....||||.              .|.:||    ....|||..|.
Mouse   221 RQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPS----IKLVYTLTVPKAT 281

  Fly   295 ---------------------KPENLTVTQKQYLP------NILALNI-----------TWARPR 321
                                 |...::|.:|.::.      .:.|:|:           .:..||
Mouse   282 VKDSGEYECAARQATKEVKEMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVREFVVEVQAYPTPR 346

  Fly   322 --YLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVL------GSHFEVHLVAQ------- 371
              :|.||.|     |.:..||:...:.:::...|..|:.::      ..|:.:  :.|
Mouse   347 ISWLKDNLT-----LIENLTEITTDVQKSQETRYQSKLKLIRAKEEDSGHYTI--IVQNEDDVKS 404

  Fly   372 ----------------------SAGGK------------------------------------NV 378
                                  |.||:                                    ||
Mouse   405 YTFELSTLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHIKKCNNDTSWTVLASNV 469

  Fly   379 SGLTLDKVHRG---------------------------------------VLLSEGNMVKLVLFI 404
            |.:..:...||                                       .|.||..:...||.:
Mouse   470 SNIITELPRRGRSTVEGRVSFAKVEETIAVRCLAKNNLSVVARELKLVAPTLRSELTVAAAVLVL 534

  Fly   405 IVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEF-HLSLMDSSGLLVTLSANESLEVMDEL 468
            :|.:...|::..:.:.::.|.|::...:::......|: ::..|             .|......
Mouse   535 LVIVIVSLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPM-------------QLPYDSRW 586

  Fly   469 EVEPHSVLLQDVLGEGAFGLVRRGV-------YKKRQVAVKLLKDEPNDEDVYAFKCEIQMLKAV 526
            |.....::|..:||.||||.|..|.       ....:||||:||......:..|...|::::..:
Mouse   587 EFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHL 651

  Fly   527 GKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFN 591
            |.|.|||.::|..|: |..:.::.|||..|.|.|:|.:                          |
Mouse   652 GPHLNIVNLLGACTK-SGPIYIITEYCFYGDLVNYLHK--------------------------N 689

  Fly   592 RLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAAD--NKGYGLEDIENIGG 654
            |              :|.:|...|:.:.|      .:.:.|    |.||  .:.|.:...||.|.
Mouse   690 R--------------DSFMSQHPEKPKKD------LDIFGL----NPADESTRSYVILSFENNGD 730

  Fly   655 SYIPKTAEAPKDRPKRKLKPQPK----KDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKY 715
            ....|.|:..:..|..:.|...|    :.|..|..:..||:...:.|..:.|...|::   .|..
Mouse   731 YMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDDSE---GLTL 792

  Fly   716 ADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGK 780
            .|||....|||.||||||....|||||||||||::..:.:||.||||:||:.|::.| .|.||..
Mouse   793 LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY-VSKGSTF 856

  Fly   781 LPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGC 844
            ||:||:|.||:...:||:.|||||:|:||:||.:|||.|||.:. .|.....::.|:||.:|:..
Mouse   857 LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHA 921

  Fly   845 TQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQ-------------------- 889
            |.|::.:|..||:|.|..||:|..|..      :..|.:|.:.|:
Mouse   922 TSEVYEIMVQCWNSEPEKRPSFYHLSE------IVENLLPGQYKKSYEKIHLDFLKSDHPAVARM 980

  Fly   890 -----------LQAATESKLKSCD-GLNSK--------------VEQVPCEEEL 917
                       .....|.|||..: ||:.:              ::.||.||:|
Mouse   981 RVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDL 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	135/407 (33%)
Pdgfra	NP_035188.2	Ig_3	28..100	CDD:464046	18/97 (19%)
		Ig	212..310	CDD:472250	21/101 (21%)
		Ig strand B	231..235	CDD:409353	1/3 (33%)
		Ig strand C	244..248	CDD:409353	3/3 (100%)
		Ig strand E	273..277	CDD:409353	3/3 (100%)
		Ig strand F	287..292	CDD:409353	0/4 (0%)
		Ig strand G	302..305	CDD:409353	1/2 (50%)
		Ig4_PDGFR	313..413	CDD:409445	15/106 (14%)
		PTKc_PDGFR_alpha	555..956	CDD:173653	142/474 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1018..1089		5/17 (29%)