DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and ver-3

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_509836.1	Gene:	ver-3 / 181289	WormBaseID:	WBGene00006896	Length:	1227	Species:	Caenorhabditis elegans

Alignment Length:	803	Identity:	186/803 - (23%)
Similarity:	317/803 - (39%)	Gaps:	215/803 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NATYI----IRVDAVKDDNKETALYLSDDNFLIL--PGLESNSTHNITALAMHGDGSYSLIAKDQ 165
            |.|:.    ::..:::..|:...:     |.||.  .|.|....|..::.|...:.|..:...|.
Worm   528 NVTFTEGMDLKCSSIRKGNRAITV-----NKLIKIGEGFEVRPHHEKSSKATESEPSKIIYEGDN 587

  Fly   166 TFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPLE 230
            ...|.:               |....||.     .:.|:  .|::...|:.|..|.:       |
Worm   588 VKLTCV---------------FPLDSDDW-----SVSWR--FENSKSSDISSIPTTT-------E 623

  Fly   231 VQFRDRKKLYRHTVDNL-----EFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTL 290
            .:.   |:..:|.:.||     .|...|...|:..:....||:.:....|:.||          :
Worm   624 TEI---KQYSKHLILNLRDVTTSFTGTYTCVVKNEDSEKLLETSIDVKAISKPS----------I 675

  Fly   291 CPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVP 355
            ...:....:.|...||..  :..|:|...|         .::..||.|....:. |.:.|...|.
Worm   676 TGGNSNAVVIVDYDQYFE--INCNMTGTPP---------PVYQWFKDGNPYTHG-DVDGSILRVS 728

  Fly   356 KITVLG-SHFEVHLVAQSAGGKNVSGL--TLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSL 417
            :  ..| ...|.|.:|.:..|..::.:  .::...:|.|.....:..|:|..|:.:  .|:.|.|
Worm   729 R--ARGEDDGEFHCLATNRAGDKLNSIEVQVNNAPKGSLFFYWFLALLLLISIIAV--FLLTCKL 789

  Fly   418 TFCRRNRSEVQALQMDAKD-AKASEFHLSLMDSSGLL----VTLSANES---LEVMDELEVEPHS 474
            ....|...:        || |..:.:...:...:|.|    ..|...|.   |...::.|::|.:
Worm   790 RASNRLTKQ--------KDIALNTLYETMIKHQAGPLPEEMKDLPVEERTYYLPYNNDYEIDPVN 846

  Fly   475 VLLQDVLGEGAFGLVRRGV----YKKRQVAVK-----LLKDEPNDEDVYAFKC---EIQMLKAVG 527
            :.:.:.:|.|.||:|::|:    |.|.::..|     .:|...|..:|...|.   |::::.|:.
Worm   847 LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIP 911

  Fly   528 KHPNIVGIVGYSTR--FSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRF 590
            |:||::.::|..|:  ...|:.::.|:...|:|:.||:..
Worm   912 KNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAH------------------------- 951

  Fly   591 NRLPRNS-IHDRIED----INNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIE 650
                ||: |::.:||    :::|.|                        :.|:...|.|..:  |
Worm   952 ----RNTFINELVEDEHVPVDDSYL------------------------VPNSVKKKIYKFD--E 986

  Fly   651 NIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKY 715
            .:|             ...|.|...|                       |.|.:|
Worm   987 KLG-------------EGTRLLVEDP-----------------------DALCTS---------- 1005

  Fly   716 ADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYR-KSGGSG 779
             |||.|..|:|.||.:||....||||||.|||||:..:.::|||||||:...::..|| |.....
Worm  1006 -DLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDT 1069

  Fly   780 KLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGC 844
            .||::|:.||.:....:|.:|||||||:.||||.||||.|||:....::::.:|.|:|.|:||.|
Worm  1070 PLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEFIRNGNRNKQPEYC 1134

  Fly   845 TQEMFSLMESCWSSVPSHRPTFS 867
            ..|::.||:.||...|..||||:
Worm  1135 HDEIYELMKVCWQFNPKDRPTFN 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	13/66 (20%)
		STYKc	475..873	CDD:214568	116/413 (28%)
		PTKc	479..873	CDD:270623	116/409 (28%)
ver-3	NP_509836.1	IG	242..>313	CDD:214652
		IG_like	578..667	CDD:214653	21/120 (18%)
		Ig_3	578..654	CDD:290638	19/107 (18%)
		I-set	673..757	CDD:254352	19/107 (18%)
		IGc2	692..747	CDD:197706	13/68 (19%)
		STYKc	847..1163	CDD:214568	116/413 (28%)
		PTKc	851..1164	CDD:270623	116/409 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910