DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and ver-1

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_497162.2	Gene:	ver-1 / 175182	WormBaseID:	WBGene00006894	Length:	1083	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	203/928 - (21%)
Similarity:	318/928 - (34%)	Gaps:	373/928 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PAPNATYIIR-----VDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAK 163
            ||.|.|...|     ::..:|:..|..|     :...|...||....:||.|:.:..|.|.|..
Worm   384 PAGNYTVTWRRTYNSIEGPRDEIVEKGL-----SATFLENSESMEVLDITDLSCNKSGKYLLSI- 442

  Fly   164 DQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWKPSAESN------------------ 210
                     .||.:                    :..|.|:.:.||:
Worm   443 ---------NYQDT--------------------SETIFWEVAVESDYPDVQLIIREPASFKVFG 478

  Fly   211 -------CYFDMVSYSTNSVNMDEPLEVQ---FRDRKKLYRHTVDNLEFDKQ--YHVGVRTVNIM 263
                   .:.::...||:...:|..||.:   |:...|:.|..|.:..|:::  |.| |.|.|:|
Worm   479 HQFYLLGTHLNIDCVSTSIPLVDALLEYRKENFKIFTKVSRSFVADGTFERKISYQV-VLTENMM 542

  Fly   264 ------NRL--------------------------ESDLQWLPIAVPS----C-LDWYPYNYTLC 291
                  ||:                          |.|...|...||.    | :.|...|.::.
Worm   543 LKCRVGNRVALETVHVADEIPNIKFKLASNKSAIYEGDTVKLTCVVPKLAGRCSITWVHRNLSIL 607

  Fly   292 PPHKPENLTVTQKQ-----YLPNILAL---NITWARPRYLPDNYTLHI----------------- 331
              |..|   ||:..     |:.|....   |.|........:|::|..
Worm   608 --HSTE---VTEHSQLSFLYIRNATTSASGNYTCVLENQASENFSLSTILKVEPIIAPYIVKTGF 667

  Fly   332 -------------------FDLFKGGT------ELNYTLDQNRSHFYVPKITVLGS---HFEVHL 368
                               :..||.||      .|.:..:.|...:........||   .||:..
Worm   668 SAPTGSKLDCNIDGRPPPEYQWFKDGTPYGTGRRLKFFEEDNSGIYQCLATNRAGSATNSFELKT 732

  Fly   369 VAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTF-------CRRNRSE 426
            ..:|.|                           :|:::.|..:.:|..|.:       .::||
Worm   733 AGRSYG---------------------------IFVLLAILALGILVILGWKISTKLGWKKNR-- 768

  Fly   427 VQALQMDAKDAKASEFHLSLMDSSGLL---VTLSANESLEV-MDELEV-EPHSVLLQDVLGEGAF 486
                     |.|.  .:.||:.|...|   ....:|.:.|. .|.||: ||        :|.|.|
Worm   769 ---------DLKL--LYKSLIGSENFLPNGKNQFSNFNFEFHKDSLEILEP--------IGSGHF 814

  Fly   487 GLVRRGVYK--KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTR--FSNQMM 547
            |:||||:.|  |..||||......:.........|::::.|:.||||::.:||..|:  ...::.
Worm   815 GVVRRGILKGTKTVVAVKSSSYRSSIGFQKVIVEELKLMSAIPKHPNVLALVGAITKNLRHGELY 879

  Fly   548 LLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLST 612
            :|:||...|:|::||      :|.:|..         :|          .:||..:
Worm   880 ILMEYIDGGNLRDFL------QQRRNVF---------ID----------ELHDNFD--------- 910

  Fly   613 VEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPK 677
                                                 |||           |..||
Worm   911 -------------------------------------ENI-----------PLIRP--------- 918

  Fly   678 KDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDL 742
                 ||.|                          |...||:.||.|:|.|||:|.....||.:|
Worm   919 -----DFNS--------------------------LSTTDLVGIAHQIANGMEWLGNVPCVHGNL 952

  Fly   743 AARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGV 807
            ..|.||||..::|:|.|:|:.      :..|||..     ::|:|.|::.||:::|:|||||||:
Worm   953 CCRKVLISKTKTIRITDYGVG------DRQRKSSS-----MRWMAPEAIEHQMFSSKSDVWSFGI 1006

  Fly   808 LLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHR 872
            .||||.||||.|||:....::|:.::.|.|..:||.|...::.||:.||.:.|..||.||
Worm  1007 CLYEIFTLGGTPYPTCVTENILKHIKNGSRNLQPEYCPSALYDLMQLCWRAPPQDRPKFS----- 1066

  Fly   873 LGGMILATNDVPERLKQL 890
                 |.:..:.::||.|
Worm  1067 -----LCSELIEKQLKDL 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	18/91 (20%)
		STYKc	475..873	CDD:214568	109/401 (27%)
		PTKc	479..873	CDD:270623	109/397 (27%)
ver-1	NP_497162.2	Ig	<294..331	CDD:299845
		ig	576..652	CDD:278476	18/80 (23%)
		IG_like	578..654	CDD:214653	18/80 (23%)
		IG_like	660..731	CDD:214653	10/70 (14%)
		IGc2	674..722	CDD:197706	6/47 (13%)
		Pkinase_Tyr	803..1072	CDD:285015	114/419 (27%)
		PTKc	807..1073	CDD:270623	112/416 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010