Protein Alignment tor and Lck

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_001155904.1
• Gene: Lck / 16818
• MGIID: 96756
• Length: 520
• Species: Mus musculus
• Alignment Length: 741
• Identity: 163/741 - (21%)
• Similarity: 251/741 - (33%)
• Gaps: 309/741 - (41%)

  Fly   200 EIEWKPSAE--SNCYFDMVSYST-------NSVNMDEPLEV---------QFRDRKKLYRHTVD- 245
            |.:|..:.:  .||::.:|...:       |...:.:||..         ..:|...:..|:.:
Mouse    21 EDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEP 85

  Fly   246 ----NLEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQY 306
                :|.|:|...:.:        ||...:|          |           |.::||..|:.:
Mouse    86 SHDGDLGFEKGEQLRI--------LEQSGEW----------W-----------KAQSLTTGQEGF 121

  Fly   307 LP-NILA-LNITWARPRYL--------------PDN----------------YTLHI--FDLFKG 337
            :| |.:| .|.....|.:.              |.|                ::|.:  ||..:|
Mouse   122 IPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 186

  Fly   338 GTELNYTL-DQNRSHFYV-PKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKL 400
            ....:|.: :.:...||: |:||..|.|                    |.|......|:|...||
Mouse   187 EVVKHYKIRNLDNGGFYISPRITFPGLH--------------------DLVRHYTNASDGLCTKL 231

  Fly   401 VLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVM 465
            ..    |            |:..:.:....:
Mouse   232 SR----P------------CQTQKPQKPWWE---------------------------------- 246

  Fly   466 DELEVEPHSVLLQDVLGEGAFGLVRRGVYK-KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKH 529
            ||.||...::.|.:.||.|.||.|..|.|. ..:||||.||......|  ||..|..::|.: :|
Mouse   247 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD--AFLAEANLMKQL-QH 308

  Fly   530 PNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLP 594
            |.:|.:  |:......:.::.||...|||.:||:         ...|:|.|:
Mouse   309 PRLVRL--YAVVTQEPIYIITEYMENGSLVDFLK---------TPSGIKLNV------------- 349

  Fly   595 RNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPK 659
                                                                             
Mouse   350 ----------------------------------------------------------------- 349

  Fly   660 TAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQ 724
                                               ||                     |||:|.|
Mouse   350 -----------------------------------NK---------------------LLDMAAQ 358

  Fly   725 VAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALE 789
            :|.||.|:.:...:||||.|.|:|:|...|.|||||||:| :..:|.|....|: |.||||.|.|
Mouse   359 IAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLAR-LIEDNEYTAREGA-KFPIKWTAPE 421

  Fly   790 SLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMES 854
            ::.:..:|.:|||||||:||.||.|.|.:|||.::..:::|.|.:|:||.||:.|.:|::.||..
Mouse   422 AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMML 486

  Fly   855 CWSSVPSHRPTFSALKHRLGGMILAT 880
            ||...|..||||..|:..|.....||
Mouse   487 CWKERPEDRPTFDYLRSVLDDFFTAT 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	107/394 (27%)
Lck	NP_001155904.1	SH3_Lck	76..129	CDD:212938	14/81 (17%)
		SH2_Src_Lck	134..234	CDD:198225	21/123 (17%)
		PTKc_Lck_Blk	248..511	CDD:270652	112/412 (27%)