Protein Alignment tor and Kdr

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_034742.2
• Gene: Kdr / 16542
• MGIID: 96683
• Length: 1345
• Species: Mus musculus
• Alignment Length: 975
• Identity: 232/975 - (23%)
• Similarity: 382/975 - (39%)
• Gaps: 317/975 - (32%)

  Fly    69 ALRKVQENYQ----MNMICRT-ESEIVFQIDW---VQHSRGTEPAPNATYIIR----VDAVKDDN 121
            ||....::||    ..:.|.. .:..:..|.|   ::.:....|...:.|..:    |:..:..|
Mouse   429 ALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVEDFQGGN 493

  Fly   122 KETALYLSDDNFLILPGLESNST--------HNITAL----AMHGDG------SYSLIAKDQTFA 168
            |   :.::.:.:.::.|  .|.|        .|::||    |::..|      |:.:|...:  .
Mouse   494 K---IEVTKNQYALIEG--KNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPE--I 551

  Fly   169 TLIRGYQPSKMGAVNLL--------------------RFVPQPDDLHHIAAEIE--WKPSAESNC 211
            |:....||::..:|:||                    ..|...:.|..:...::  ||.:.
Mouse   552 TVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNG---- 612

  Fly   212 YFDMVSYSTNSVNMDEPLEVQF---------------RDRKKLYRHTVDNLEFDKQYHVGVRTVN 261
              .|.|.|||.:     |.|.|               :|:|...||.:            |:.:.
Mouse   613 --TMFSNSTNDI-----LIVAFQNASLQDQGDYVCSAQDKKTKKRHCL------------VKQLI 658

  Fly   262 IMNR----LESDLQWLPIAVPSCLDWYPYNYTLCP------PHKPENLTVTQKQYLPNILALNIT 316
            |:.|    :..:|:.....:...::      ..||      ||                    ||
Mouse   659 ILERMAPMITGNLENQTTTIGETIE------VTCPASGNPTPH--------------------IT 697

  Fly   317 WARPRYLPDNYTLHIFD---LFKGGTELNYTLDQNRSH----FYVPKITVLG-SHFEVHLVAQSA 373
            |.:     ||.|| :.|   :.:.|.. |.|:.:.|..    :......||| :..|...:.:.|
Mouse   698 WFK-----DNETL-VEDSGIVLRDGNR-NLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGA 755

  Fly   374 GGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAK 438
                     .:|.:..|::..|..|..:.|.:     :|::...|..|.|..|::
Mouse   756 ---------QEKTNLEVIILVGTAVIAMFFWL-----LLVIVLRTVKRANEGELK---------- 796

  Fly   439 ASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHS----------VLLQDVLGEGAFGLVRR-- 491
                       :|.|..:...:.|.:.:..|..|:.          :.|...||.||||.|..
Mouse   797 -----------TGYLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEAD 850

  Fly   492 --GVYKK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIE 551
              |:.|.   :.||||:||:.....:..|...|:::|..:|.|.|:|.::|..|:....:|:::|
Mouse   851 AFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE 915

  Fly   552 YCSLGSLQNFL---REEW--------KFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDI 605
            :|..|:|..:|   |.|:        :|||.::.:|     |.:||.:|           |::.|
Mouse   916 FCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVG-----ELSVDLKR-----------RLDSI 964

  Fly   606 NNSMLST----VEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKD 666
            .:|..|.    |||:|                            |.|:|
Mouse   965 TSSQSSASSGFVEEKS----------------------------LSDVE---------------- 985

  Fly   667 RPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEF 731
                      ::::.::...|     |...|:..|                   .:.|||.||||
Mouse   986 ----------EEEASEELYKD-----FLTLEHLIC-------------------YSFQVAKGMEF 1016

  Fly   732 LAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVY-RKSGGSGKLPIKWLALESLTHQV 795
            ||..|.:||||||||:|:|....:||.||||:||:|.:..| ||  |..:||:||:|.|::..:|
Mouse  1017 LASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK--GDARLPLKWMAPETIFDRV 1079

  Fly   796 YTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSV 859
            ||.|||||||||||:||.:||..|||.|. ..:..:.|::|.||:.|:..|.||:..|..||...
Mouse  1080 YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHED 1144

  Fly   860 PSHRPTFSALKHRLGGMILAT--NDVPERLKQLQAATESKLKSCDGLNSKVEQVPC-EEELYLEP 921
            |:.||:||.|...||.::.|.  .|..:.:....:.|.| ::...||:.....|.| |||...:|
Mouse  1145 PNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLS-MEEDSGLSLPTSPVSCMEEEEVCDP 1208

  Fly   922  921
            Mouse  1209  1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	133/417 (32%)
Kdr	NP_034742.2	Ig	226..327	CDD:472250
		Ig strand B	244..248	CDD:409353
		Ig strand C	259..263	CDD:409353
		Ig strand E	292..296	CDD:409353
		Ig strand F	306..311	CDD:409353
		Ig strand G	319..322	CDD:409353
		Ig	331..419	CDD:472250
		Ig strand B	350..354	CDD:409353
		Ig strand C	363..367	CDD:409353
		Ig strand E	383..387	CDD:409353
		Ig strand F	397..402	CDD:409353
		Ig strand G	412..415	CDD:409353
		Ig_3	549..642	CDD:464046	18/105 (17%)
		I-set	665..742	CDD:400151	18/109 (17%)
		Ig strand B	682..686	CDD:409353	0/9 (0%)
		Ig strand C	695..699	CDD:409353	3/23 (13%)
		Ig strand E	718..722	CDD:409353	1/4 (25%)
		Ig strand F	732..737	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	757..791	CDD:375470	8/38 (21%)
		PTKc_VEGFR2	824..1165	CDD:270681	136/436 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1272..1316