DRSC/TRiP Functional Genomics Resources

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Protein Alignment tor and CSF1R

DIOPT Version :10

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_005202.2 Gene:CSF1R / 1436 HGNCID:2433 Length:972 Species:Homo sapiens


Alignment Length:939 Identity:217/939 - (23%)
Similarity:362/939 - (38%) Gaps:295/939 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 PAPNATYIIRVDAVKDDNKETALYLS----DDNFLILPGLESNSTHNITALAMHGDGSYSLIAKD 164
            |.|.|..::..:.|:...:...:..|    |.||.:.      ..||.|.||         |.:.
Human   200 PGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVF------LQHNNTKLA---------IPQQ 249

  Fly   165 QTFATLIRGYQPSKMGAVNLLRFVPQPDDLHH-----IAAEIEWKPSAESNCYFDMVSYSTNSVN 224
            ..|..  ..||  |:..:||    .|.|..|.     :|:.::.|.|  ::.:|.:|..:..:::
Human   250 SDFHN--NRYQ--KVLTLNL----DQVDFQHAGNYSCVASNVQGKHS--TSMFFRVVESAYLNLS 304

  Fly   225 MDEPLEVQFRDRKKLYRHTVD---NLEFDKQYHVGVRTVNIMNRLE--SDLQWLP-IAVPSCLDW 283
            .::.|         :...||.   ||:...:.:.|::..| ...|.  ||.|..| :|..:..|.
Human   305 SEQNL---------IQEVTVGEGLNLKVMVEAYPGLQGFN-WTYLGPFSDHQPEPKLANATTKDT 359

  Fly   284 YPYNYTLCPPH-KPE--------------------NLTVTQKQYLPNILAL-------------- 313
            |.:.:||..|. ||.                    .||:   :|.|.:..:              
Human   360 YRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTL---RYPPEVSVIWTFINGSGTLLCAA 421

  Fly   314 ------NITWARPRYLPDN----YTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHL 368
                  |:||.:.....|.    ..|.::|     ......|.|...|    |:||         
Human   422 SGYPQPNVTWLQCSGHTDRCDEAQVLQVWD-----DPYPEVLSQEPFH----KVTV--------- 468

  Fly   369 VAQSAGGKNVSGLTLD----------KVHRGVLLSEGNMVKL-----------VLFIIVPICC-- 410
              ||.       ||::          :.|..|.......:.:           .||..|.:.|  
Human   469 --QSL-------LTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMS 524

  Fly   411 -----ILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDS-SGLLVTLSANESLEVMDELE 469
                 :|:|..|.:..:.:.:.|.             ...:::| .|...|......|...::.|
Human   525 IMALLLLLLLLLLYKYKQKPKYQV-------------RWKIIESYEGNSYTFIDPTQLPYNEKWE 576

  Fly   470 VEPHSVLLQDVLGEGAFGLVRR----GVYKK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVG 527
            ...:::.....||.||||.|..    |:.|:   .:||||:||...:.::..|...|::::..:|
Human   577 FPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG 641

  Fly   528 KHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNR 592
            :|.|||.::|..|. ...::::.|||..|.|.||||     |:.:..:|  .:|....|      
Human   642 QHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLR-----RKAEAMLG--PSLSPGQD------ 692

  Fly   593 LPRNSIHDRIEDINNSMLSTVEEESESDQTHSSR-CETYTLTRITNAADNKGYGLEDIENIGGSY 656
             |...:     |..|..|.  ::....|...||: .:||...|..:.:.|..:..:|::      
Human   693 -PEGGV-----DYKNIHLE--KKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLD------ 743

  Fly   657 IPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDI 721
                                |:|.:                              ||:..|||..
Human   744 --------------------KEDGR------------------------------PLELRDLLHF 758

  Fly   722 AQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWL 786
            :.|||.||.|||....:|||:||||||::.....||.||||:||:.:::.|... |:.:||:||:
Human   759 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVK-GNARLPVKWM 822

  Fly   787 ALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSV-SPSDLLQLLRQGHRMKRPEGCTQEMFS 850
            |.||:...|||.||||||:|:||:||.:||..|||.: ..|...:|::.|::|.:|....:.::|
Human   823 APESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYS 887

  Fly   851 LMESCWSSVPSHRPTFSAL----------------------KHRLGGMILATNDVPERLKQLQAA 893
            :|::||:..|:|||||..:                      ..|.||...:::::.|.       
Human   888 IMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEE------- 945

  Fly   894 TESKLKSCDGLNSKVEQVPCEEELYLEPL 922
            :.|:..:|           ||:....:||
Human   946 SSSEHLTC-----------CEQGDIAQPL 963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 PTKc 479..873 CDD:270623 124/424 (29%)
CSF1RNP_005202.2 IG_like 28..85 CDD:214653
Ig strand B 38..42 CDD:409353
Ig strand C 55..58 CDD:409353
Ig strand E 66..71 CDD:409353
Ig strand F 81..86 CDD:409353
Ig strand G 94..97 CDD:409353
IgI_3_CSF-1R 203..295 CDD:409530 25/116 (22%)
Ig strand A 203..208 CDD:409530 1/4 (25%)
Ig strand A' 210..216 CDD:409530 1/5 (20%)
Ig strand B 220..228 CDD:409530 1/7 (14%)
Ig strand C 234..238 CDD:409530 0/9 (0%)
Ig strand C' 241..244 CDD:409530 1/2 (50%)
Ig strand D 248..253 CDD:409530 0/4 (0%)
Ig strand E 257..265 CDD:409530 3/9 (33%)
Ig strand F 274..282 CDD:409530 1/7 (14%)
Ig strand G 285..295 CDD:409530 3/11 (27%)
IgI_4_SCFR_like 299..400 CDD:409364 22/113 (19%)
Ig strand A 299..305 CDD:409364 0/5 (0%)
Ig strand A' 309..314 CDD:409364 1/13 (8%)
Ig strand B 317..327 CDD:409364 2/9 (22%)
Ig strand C 331..338 CDD:409364 1/7 (14%)
Ig strand C' 340..343 CDD:409364 0/2 (0%)
Ig strand D 347..352 CDD:409364 1/4 (25%)
Ig strand E 361..370 CDD:409364 2/8 (25%)
Ig strand F 377..385 CDD:409364 0/7 (0%)
Ig strand G 388..399 CDD:409364 2/13 (15%)
Ig_3 401..489 CDD:464046 17/114 (15%)
Regulatory juxtamembrane domain 542..574 5/44 (11%)
PTKc_CSF-1R 543..914 CDD:133237 130/462 (28%)
Activation loop 796..818 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..950 5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

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