DRSC/TRiP Functional Genomics Resources

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Protein Alignment tor and CSF1R

DIOPT Version :9

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_001275634.1 Gene:CSF1R / 1436 HGNCID:2433 Length:972 Species:Homo sapiens


Alignment Length:939 Identity:217/939 - (23%)
Similarity:362/939 - (38%) Gaps:295/939 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 PAPNATYIIRVDAVKDDNKETALYLS----DDNFLILPGLESNSTHNITALAMHGDGSYSLIAKD 164
            |.|.|..::..:.|:...:...:..|    |.||.:.      ..||.|.||         |.:.
Human   200 PGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVF------LQHNNTKLA---------IPQQ 249

  Fly   165 QTFATLIRGYQPSKMGAVNLLRFVPQPDDLHH-----IAAEIEWKPSAESNCYFDMVSYSTNSVN 224
            ..|..  ..||  |:..:||    .|.|..|.     :|:.::.|.|  ::.:|.:|..:..:::
Human   250 SDFHN--NRYQ--KVLTLNL----DQVDFQHAGNYSCVASNVQGKHS--TSMFFRVVESAYLNLS 304

  Fly   225 MDEPLEVQFRDRKKLYRHTVD---NLEFDKQYHVGVRTVNIMNRLE--SDLQWLP-IAVPSCLDW 283
            .::.|         :...||.   ||:...:.:.|::..| ...|.  ||.|..| :|..:..|.
Human   305 SEQNL---------IQEVTVGEGLNLKVMVEAYPGLQGFN-WTYLGPFSDHQPEPKLANATTKDT 359

  Fly   284 YPYNYTLCPPH-KPE--------------------NLTVTQKQYLPNILAL-------------- 313
            |.:.:||..|. ||.                    .||:   :|.|.:..:              
Human   360 YRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTL---RYPPEVSVIWTFINGSGTLLCAA 421

  Fly   314 ------NITWARPRYLPDN----YTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHL 368
                  |:||.:.....|.    ..|.::|     ......|.|...|    |:||         
Human   422 SGYPQPNVTWLQCSGHTDRCDEAQVLQVWD-----DPYPEVLSQEPFH----KVTV--------- 468

  Fly   369 VAQSAGGKNVSGLTLD----------KVHRGVLLSEGNMVKL-----------VLFIIVPICC-- 410
              ||.       ||::          :.|..|.......:.:           .||..|.:.|  
Human   469 --QSL-------LTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMS 524

  Fly   411 -----ILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDS-SGLLVTLSANESLEVMDELE 469
                 :|:|..|.:..:.:.:.|.             ...:::| .|...|......|...::.|
Human   525 IMALLLLLLLLLLYKYKQKPKYQV-------------RWKIIESYEGNSYTFIDPTQLPYNEKWE 576

  Fly   470 VEPHSVLLQDVLGEGAFGLVRR----GVYKK---RQVAVKLLKDEPNDEDVYAFKCEIQMLKAVG 527
            ...:::.....||.||||.|..    |:.|:   .:||||:||...:.::..|...|::::..:|
Human   577 FPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG 641

  Fly   528 KHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNR 592
            :|.|||.::|..|. ...::::.|||..|.|.||||     |:.:..:|  .:|....|      
Human   642 QHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLR-----RKAEAMLG--PSLSPGQD------ 692

  Fly   593 LPRNSIHDRIEDINNSMLSTVEEESESDQTHSSR-CETYTLTRITNAADNKGYGLEDIENIGGSY 656
             |...:     |..|..|.  ::....|...||: .:||...|..:.:.|..:..:|::      
Human   693 -PEGGV-----DYKNIHLE--KKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLD------ 743

  Fly   657 IPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDI 721
                                |:|.:                              ||:..|||..
Human   744 --------------------KEDGR------------------------------PLELRDLLHF 758

  Fly   722 AQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWL 786
            :.|||.||.|||....:|||:||||||::.....||.||||:||:.:::.|... |:.:||:||:
Human   759 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVK-GNARLPVKWM 822

  Fly   787 ALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSV-SPSDLLQLLRQGHRMKRPEGCTQEMFS 850
            |.||:...|||.||||||:|:||:||.:||..|||.: ..|...:|::.|::|.:|....:.::|
Human   823 APESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYS 887

  Fly   851 LMESCWSSVPSHRPTFSAL----------------------KHRLGGMILATNDVPERLKQLQAA 893
            :|::||:..|:|||||..:                      ..|.||...:::::.|.       
Human   888 IMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEE------- 945

  Fly   894 TESKLKSCDGLNSKVEQVPCEEELYLEPL 922
            :.|:..:|           ||:....:||
Human   946 SSSEHLTC-----------CEQGDIAQPL 963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 FN3 199..261 CDD:214495 10/64 (16%)
STYKc 475..873 CDD:214568 124/428 (29%)
PTKc 479..873 CDD:270623 124/424 (29%)
CSF1RNP_001275634.1 IG_like 28..85 CDD:214653
ig 207..293 CDD:365836 23/110 (21%)
Ig4_SCFR_like 299..400 CDD:319281 22/113 (19%)
Ig 416..495 CDD:319273 18/105 (17%)
Regulatory juxtamembrane domain 542..574 5/44 (11%)
PTKc_CSF-1R 543..914 CDD:133237 130/462 (28%)
Activation loop 796..818 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..950 5/38 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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