Protein Alignment tor and Flt4

DIOPT Version :10

• Sequence 1: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_032055.1
• Gene: Flt4 / 14257
• MGIID: 95561
• Length: 1363
• Species: Mus musculus
• Alignment Length: 887
• Identity: 228/887 - (25%)
• Similarity: 344/887 - (38%)
• Gaps: 264/887 - (29%)

  Fly    69 ALRKVQENYQMNMICRTESEIVFQ--------ID-WVQHSRGTEPAPNATYI-----------IR 113
            :||:.|:...|.. ||...|:..|        :| |.:...|.....:...|           :.
Mouse   473 SLRRRQQRDGMPQ-CRDWKEVTTQDAVNPIESLDSWTEFVEGKNKTVSKLVIQDANVSAMYKCVV 536

  Fly   114 VDAVKDDNKETALYLS--DDNFLI--------LPGLE-------SNSTH--------NITALAMH 153
            |:.|..|.:....|::  .|.|.|        |.|..       .|.|:        |::.|...
Mouse   537 VNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDA 601

  Fly   154 GDGSYSLIAKD-QTFAT-LIRGYQPSKMGA--VNLLRFVPQ--PDDLHHIAAEIEWKPSAESNCY 212
            ......|..|: ..||| |....:.::.||  ..|...:|:  |:|......|::.:.|.:.:|:
Mouse   602 QGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCH 666

  Fly   213 FDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESDLQWLPIA- 276
                         .:.|.||..:..:|.::..|.|            ||:.:.||   ...|:|
Mouse   667 -------------KKYLSVQALEAPRLTQNLTDLL------------VNVSDSLE---MRCPVAG 703

  Fly   277 --VPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGT 339
              |||.: ||          |.|.|  .:|:                               .|.
Mouse   704 AHVPSIV-WY----------KDERL--LEKE-------------------------------SGI 724

  Fly   340 ELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGK------NVSGLTLDKVHRGVLLSE--GN 396
            :|   .|.|:             ...:..|.:...|:      |..|.........|..||  |:
Mouse   725 DL---ADSNQ-------------RLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGS 773

  Fly   397 MVKLVLF---IIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSA 458
            |..::|.   :|.....:|:|  |.||...|    ....|.|..     :||::...|   .:..
Mouse   774 MEIVILIGTGVIAVFFWVLLL--LIFCNMKR----PAHADIKTG-----YLSIIMDPG---EVPL 824

  Fly   459 NESLEVM----DELEVEPHSVLLQDVLGEGAFGLVRR----GVYKKRQ---VAVKLLKDEPNDED 512
            .|..|.:    .:.|.....:.|..|||.||||.|..    |:.|...   ||||:||:.....:
Mouse   825 EEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASE 889

  Fly   513 VYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGL 577
            ..|...|:::|..:|.|.|:|.::|..|:.:..:|:::|:|..|:|.||||.:   |...|...
Mouse   890 HRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVK---RDTFNPYA- 950

  Fly   578 KKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNK 642
            :|:.||   .|||..:...:..||            .....||:.      .:|...:...:..:
Mouse   951 EKSPEQ---RRRFRAMVEGAKADR------------RRPGSSDRA------LFTRFLMGKGSARR 994

  Fly   643 GYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDT 707
            ...:::.|::..|
Mouse   995 APLVQEAEDLWLS---------------------------------------------------- 1007

  Fly   708 KPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVY 772
                ||...||:..:.|||.||||||..|.:||||||||:|:|....:||.||||:||:|.:..|
Mouse  1008 ----PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDY 1068

  Fly   773 -RKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQG 835
             ||  ||.:||:||:|.||:..:|||:|||||||||||:||.:||..|||.|. ..:..|.|:.|
Mouse  1069 VRK--GSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDG 1131

  Fly   836 HRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI 877
            .||:.||..|..:..:|:||||..|..||.||.|...||.::
Mouse  1132 TRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLL 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	PTKc	479..873	CDD:270623	135/402 (34%)
Flt4	NP_032055.1	IgI_VEGFR	230..329	CDD:409448
		Ig strand A	230..234	CDD:409448
		Ig strand A'	240..244	CDD:409448
		Ig strand B	246..255	CDD:409448
		Ig strand C	262..267	CDD:409448
		Ig strand C'	270..272	CDD:409448
		Ig strand D	276..284	CDD:409448
		Ig strand E	289..297	CDD:409448
		Ig strand F	307..313	CDD:409448
		Ig strand G	318..324	CDD:409448
		Ig	331..418	CDD:472250
		Ig strand B	352..356	CDD:409449
		Ig strand C	365..369	CDD:409449
		Ig strand E	382..386	CDD:409449
		Ig strand F	396..401	CDD:409449
		Ig strand G	411..414	CDD:409449
		IG_like	570..663	CDD:214653	19/92 (21%)
		Ig strand B	574..578	CDD:409353	0/3 (0%)
		Ig strand C	587..591	CDD:409353	0/3 (0%)
		Ig strand E	636..640	CDD:409353	1/3 (33%)
		Ig strand F	650..655	CDD:409353	0/4 (0%)
		Ig	678..765	CDD:472250	26/161 (16%)
		Ig strand B	695..699	CDD:409353	2/6 (33%)
		Ig strand C	708..712	CDD:409353	1/4 (25%)
		Ig strand E	731..735	CDD:409353	0/16 (0%)
		Ig strand F	745..750	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	770..804	CDD:375470	10/39 (26%)
		Protein Kinases, catalytic domain	837..1175	CDD:473864	139/420 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1330