DRSC/TRiP Functional Genomics Resources

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Protein Alignment tor and Flt3

DIOPT Version :10

Sequence 1:NP_476762.1 Gene:tor / 35717 FlyBaseID:FBgn0003733 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_034359.2 Gene:Flt3 / 14255 MGIID:95559 Length:1000 Species:Mus musculus


Alignment Length:998 Identity:235/998 - (23%)
Similarity:385/998 - (38%) Gaps:261/998 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AKYAFIFWFFVGSNQGEML---LMDKISHDKTLLNVTACTQNCLEKG----QMDFRSC---LKDC 60
            |.|..:|...|...|..:|   ...|:.:...||        |:.:|    .:::..|   .:.|
Mouse   151 ANYTVLFTVNVRDTQLYVLRRPYFRKMENQDALL--------CISEGVPEPTVEWVLCSSHRESC 207

  Fly    61 RINGTFPGALRK----VQENYQMNMICRTESEI------VFQIDWVQHSRGTEPAPNATYIIRVD 115
            :..|  |..:||    :.|.:..::.|...:.:      :|.||..|..:.|.|           
Mouse   208 KEEG--PAVVRKEEKVLHELFGTDIRCCARNALGRECTKLFTIDLNQAPQSTLP----------- 259

  Fly   116 AVKDDNKETALYLSDDNFLILPGLESNSTHNIT------ALAMHGDGSYSLIAKDQTFATLIR-- 172
                   :..|.:.:..::....:..|....:|      ||.   :|||..::...|..|:||  
Mouse   260 -------QLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALE---EGSYFEMSTYSTNRTMIRIL 314

  Fly   173 ------------GY-------QPSKMGAVNLLR--FVP--------QPDDLHHIAAEIEWKPSAE 208
                        ||       .||:...|.:|.  |:.        :.|........:.:|....
Mouse   315 LAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPR 379

  Fly   209 SNC--YFDMVSYSTNSVNMDEPLEV-QFRDRKK-----LYRHTVDNLEFDKQYHVGVRTVNIMNR 265
            ..|  .|...|:......:::...: :|.|.|.     ::....|:.:|.|.:     |:||..:
Mouse   380 IRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMF-----TLNIRKK 439

  Fly   266 LESDLQWLPIAVPSC-LDWYP---YNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDN 326
            .:. |.....:..|| .|.||   :.:..|....| |.|    :.:|..:     |.:      .
Mouse   440 PQV-LANASASQASCSSDGYPLPSWTWKKCSDKSP-NCT----EEIPEGV-----WNK------K 487

  Fly   327 YTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVL 391
            ....:|..:...:.||              ::..|....|...|.::.|.:...:.|:.......
Mouse   488 ANRKVFGQWVSSSTLN--------------MSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPF 538

  Fly   392 LSEGNMVKLVLFIIVPICCILMLCSLTFCR------RNRSEVQALQMDAKDAKASEFHLSLMDSS 450
            :.:.......:.:.:|...:|:   :..|.      |..|::|.:|:.. ......|::...|..
Mouse   539 IQDNISFYATIGLCLPFIVVLI---VLICHKYKKQFRYESQLQMIQVTG-PLDNEYFYVDFRDYE 599

  Fly   451 GLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRR----GVYK---KRQVAVKLLKDEP 508
            ..|......|:||             ...|||.||||.|..    |:.|   ..|||||:||::.
Mouse   600 YDLKWEFPRENLE-------------FGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKA 651

  Fly   509 NDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLR-EEWKFRQEQ 572
            :..:..|...|::|:..:|.|.|||.::|..| .|..:.|:.|||..|.|.|:|| :..||.:..
Mouse   652 DSCEKEALMSELKMMTHLGHHDNIVNLLGACT-LSGPVYLIFEYCCYGDLLNYLRSKREKFHRTW 715

  Fly   573 NAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITN 637
            ..|..:.|         |:..|....|.     |:||     ..|...|.|..            
Mouse   716 TEIFKEHN---------FSFYPTFQAHS-----NSSM-----PGSREVQLHPP------------ 749

  Fly   638 AADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCL 702
                    |:.:....|:.|                     .|:.:.:.:|:||:.|.:|     
Mouse   750 --------LDQLSGFNGNLI---------------------HSEDEIEYENQKRLAEEEE----- 780

  Fly   703 DSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVY 767
              .|..   .|.:.|||..|.|||.|||||.....|||||||||||::..:.:||.||||:||:.
Mouse   781 --EDLN---VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIL 840

  Fly   768 HENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSD--LLQ 830
            .::.| ...|:.:||:||:|.|||...:||.:|||||:|:||:||.:||..|||.: |.|  ..:
Mouse   841 SDSSY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI-PVDANFYK 903

  Fly   831 LLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQLQAATE 895
            |::.|.:|::|...|:.::.:|:|||:.....||:|..|...||             .||..|.|
Mouse   904 LIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLG-------------CQLAEAEE 955

  Fly   896 SKLKSCDGLNSKVEQVPCEEELY 918
            :..::..|      .||....:|
Mouse   956 AMYQNMGG------NVPEHPSIY 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
torNP_476762.1 PTKc 479..873 CDD:270623 134/403 (33%)
Flt3NP_034359.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..67
ig 256..346 CDD:395002 19/110 (17%)
Ig strand B 269..273 CDD:409353 0/3 (0%)
Ig strand C 283..287 CDD:409353 1/3 (33%)
Ig strand E 315..318 CDD:409353 0/2 (0%)
Ig strand F 328..333 CDD:409353 1/4 (25%)
7tm_GPCRs <491..>586 CDD:475119 15/112 (13%)
Protein Kinases, catalytic domain 573..950 CDD:473864 145/476 (30%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250 592..598 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1000 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

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