DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and Fgfr3

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001156689.1	Gene:	Fgfr3 / 14184	MGIID:	95524	Length:	802	Species:	Mus musculus

Alignment Length:	530	Identity:	166/530 - (31%)
Similarity:	234/530 - (44%)	Gaps:	179/530 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 VHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHL------ 444
            |:.|| ||.|    :|.|:.:.:...::||.|      ||..:.........|.|.|.|
Mouse   368 VYAGV-LSYG----VVFFLFILVVAAVILCRL------RSPPKKGLGSPTVHKVSRFPLKRQVSL 421

  Fly   445 ---SLMDSSGLLV---TLSANES--LEVMDELEV--EPH------SVLLQDVLGEGAFGLV---- 489
               |.|:|:..||   .||:.|.  |..:.|||:  :|.      .:.|...||||.||.|
Mouse   422 ESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAE 486

  Fly   490 RRGVYKKR-----QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLL 549
            ..|:.|.|     .||||:|||:..|:|:.....|::|:|.:|||.||:.::|..|: ...:.:|
Mouse   487 AIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVL 550

  Fly   550 IEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVE 614
            :||.:.|:|:.|||..
Mouse   551 VEYAAKGNLREFLRAR------------------------------------------------- 566

  Fly   615 EESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKD 679
                                                                ||       |..|
Mouse   567 ----------------------------------------------------RP-------PGMD 572

  Fly   680 SKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIP---LKYADLLDIAQQVAVGMEFLAQNKVVHRD 741
            ..                 ||..       |:|   |...||:..|.|||.|||:||..|.:|||
Mouse   573 YS-----------------FDAC-------RLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRD 613

  Fly   742 LAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFG 806
            |||||||::.|..:|||||||:|||::.:.|:|: .:|:||:||:|.|:|..:|||.||||||||
Mouse   614 LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT-TNGRLPVKWMAPEALFDRVYTHQSDVWSFG 677

  Fly   807 VLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKH 871
            |||:||.||||.|||.:...:|.:||::||||.:|..||.:::.:|..||.:|||.||||..|..
Mouse   678 VLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVE 742

  Fly   872 RLGGMILATN 881
            .|..::..|:
Mouse   743 DLDRILTVTS 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495
		STYKc	475..873	CDD:214568	134/409 (33%)
		PTKc	479..873	CDD:270623	133/405 (33%)
Fgfr3	NP_001156689.1	IGc2	51..110	CDD:197706
		IG	52..108	CDD:214652
		Ig2_FGFR	155..239	CDD:143265
		IG_like	254..349	CDD:214653
		Ig3_FGFR	262..350	CDD:143175
		PTKc_FGFR3	455..788	CDD:173652	137/432 (32%)
		Pkinase_Tyr	468..744	CDD:285015	134/409 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910