DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Flt3

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001094292.1	Gene:	Flt3 / 140635	RGDID:	61308	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	922	Identity:	220/922 - (23%)
Similarity:	358/922 - (38%)	Gaps:	238/922 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DKISHDKTLLNVTACTQNCLEKGQMDFRSCLKDCRIN------GTFPGALRKVQENYQMNMICRT 85
            :|:.|:....::..|.:|.|.      |.|.|...|:      .|.|....||.|...:.  |:.
  Rat   218 EKVLHELFETDIRCCARNALG------RECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIR--CKA 274

  Fly    86 -ESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFL-ILPGLESNSTHNIT 148
             .....|.:.|   ..|.:.....:|.           |.:.|.::.:.: ||....|:...|.|
  Rat   275 IHVNHGFGLTW---ELGNKVLEEGSYF-----------EMSSYSTNRSMIRILLAFVSSVGRNNT 325

  Fly   149 ALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLR--FVP--------QPDDLHHIAAEIEW 203
                   |.|          |......||:...|.:|.  |:.        :.|........:.:
  Rat   326 -------GYY----------TCSSSKHPSQTALVTILEKGFINATSSQEEYEIDPYEKFCFSVRF 373

  Fly   204 KPSAESNC--YFDMVSYSTNSVNMDEPLEV-QFRDRKK-----LYRHTVDNLEFDKQYHVGVRTV 260
            |...:..|  .|...|:......:::...: :|.|.|.     ::....|:.:|.|.:.:.:|
  Rat   374 KAYPQIRCKWTFSQTSFPCEQSGLEDGYSISKFCDHKNNPGEYIFHGENDDAQFTKMFILNIR-- 436

  Fly   261 NIMNRLESDLQWLPIAVPSCL-DWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLP 324
                |....|.....:..||. |.||                     ||     |.||.:.....
  Rat   437 ----RKPQVLANASASQASCFSDGYP---------------------LP-----NWTWKKCSDKS 471

  Fly   325 DNYTLHIFDLFKGGTELNYTLDQNRSHF--YVPKITV----LGSHFEVHLVAQSAGGKNVSGLTL 383
            .|.|..|       .|..:....||..|  :|...|:    .|..|.|...|.::.|.:...:.|
  Rat   472 PNCTEEI-------PEGVWNKKANRKVFGQWVSSSTLNMSEAGRGFLVKCCAYNSMGTSCETILL 529

  Fly   384 DKVHRGVLLSEGNMVKLVLFIIVPIC-CILMLCSLTFCR------RNRSEVQALQMDAKDAKASE 441
            :.....:.:.:    .:..:..:.:| ..:::.::..|.      |..|::|.:|:.. ......
  Rat   530 NSPGPFLFIQD----NISFYATIGLCPPFIVVLTVLICHKYKKQFRYESQLQMIQVTG-PLDNEY 589

  Fly   442 FHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRR----GVYK---KRQV 499
            |::...|....|......|:||             ...|||.||||.|..    |:.|   ..||
  Rat   590 FYIDFRDYEYDLKWEFPRENLE-------------FGKVLGSGAFGRVMNATAYGISKTGVSIQV 641

  Fly   500 AVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLRE 564
            |||:||::.:..:..|...|::|:..:|.|.|||.::|..| .|..:.|:.|||..|.|.|:||.
  Rat   642 AVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLGACT-LSGPVYLIFEYCCHGDLLNYLRS 705

  Fly   565 EWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCET 629
            :                     ..:|:|    :..:..::.|.|...|.:..|.|....|...:.
  Rat   706 K---------------------REKFHR----TWTEIFKEHNFSFYPTFQSHSNSSMPGSREVQI 745

  Fly   630 YTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFE 694
            |.             .::.:....|:.|                     .|:.:.:.:|:||:.|
  Rat   746 YP-------------PVDQVSGFNGNSI---------------------HSEGNIEYENQKRLEE 776

  Fly   695 NKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIAD 759
            .:|       .|..   .|.:.|||..|.|||.|||||.....|||||||||||::..:.:||.|
  Rat   777 EEE-------EDLN---VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 831

  Fly   760 FGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS 824
            |||:||:..::.| ...|:.:||:||:|.|||...:||.:|||||:|:||:||.:||..|||.:
  Rat   832 FGLARDILSDSSY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI- 894

  Fly   825 PSD--LLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTF---------------SALKHR 872
            |.|  ..:|::.|.:|::|...|:|::.:|:|||:.....||:|               :|:...
  Rat   895 PVDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEAAMYQN 959

  Fly   873 LGGMILATNDVP 884
            :||      |||
  Rat   960 MGG------DVP 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	11/69 (16%)
		STYKc	475..873	CDD:214568	130/421 (31%)
		PTKc	479..873	CDD:270623	130/417 (31%)
Flt3	NP_001094292.1	ig	255..345	CDD:278476	23/122 (19%)
		PKc_like	572..949	CDD:304357	138/462 (30%)
		Pkinase_Tyr	610..945	CDD:285015	131/419 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010