DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tor and Flt4

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_446104.2	Gene:	Flt4 / 114110	RGDID:	621737	Length:	1363	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	209/830 - (25%)
Similarity:	316/830 - (38%)	Gaps:	253/830 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ENYQMNMICRTESEIVFQIDWVQHSRGTEPAPNATYIIRVDAVKDDNKETALYLSDDNFLILPGL 139
            |...:.:.||.::.....:.|              |.:.:..:.|......|....:..|....|
  Rat   570 EGQSVRLSCRADNYTYEHLRW--------------YRLNLSTLHDAQGNPLLLDCKNVHLFATPL 620

  Fly   140 ESNSTHNITALAMHGDGSYSLIAKDQTFATLIRGYQPSKMGAVNLLRFVPQPDDLHHIAAEIEWK 204
            |:| .......|.|              |||          ::|:.|..  |:|......|::.:
  Rat   621 EAN-LEEAEPGARH--------------ATL----------SLNIPRVA--PEDEGDYVCEVQDR 658

  Fly   205 PSAESNCYFDMVSYSTNSVNMDEPLEVQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLESD 269
            .:.:.:|:             .:.|.||..:..:|.::..|.|            ||:.:.||
  Rat   659 RNQDKHCH-------------KKYLSVQALEAPRLTQNLTDLL------------VNVSDSLE-- 696

  Fly   270 LQWLPIA---VPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHI 331
             ...|:|   |||.: ||          |.|.|  .:|:
  Rat   697 -MRCPVAGAHVPSIV-WY----------KDERL--LEKE-------------------------- 721

  Fly   332 FDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGK------NVSGLTLDKVHRGV 390
                 .|.:|   .|.|:             ...:..|.:...|:      |..|.........|
  Rat   722 -----SGIDL---ADSNQ-------------RLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAV 765

  Fly   391 LLSE--GNMVKLVLF---IIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEFHLSLMDSS 450
            ..||  |:|..::|.   :|.....:|:|  |.||...|    ....|.|..     :||::...
  Rat   766 EGSEDKGSMEIVILIGTGVIAVFFWVLLL--LIFCNMKR----PAHADIKTG-----YLSIIMDP 819

  Fly   451 GLLVTLSANESLEVM----DELEVEPHSVLLQDVLGEGAFGLVRR----GVYKKRQ---VAVKLL 504
            |   .:...|..|.:    .:.|.....:.|..|||.||||.|..    |:.|...   ||||:|
  Rat   820 G---EVPLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKML 881

  Fly   505 KDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFR 569
            |:.....:..|...|:::|..:|.|.|:|.::|..|:.:..:|:::|:|..|:|.||||    .:
  Rat   882 KEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLR----VK 942

  Fly   570 QEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTR 634
            :|......:|:.||   .|||.                    .:.|.:::|:......:....||
  Rat   943 RETFDPYAEKSPEQ---RRRFR--------------------AMVEGAKADRRRLGSTDRALFTR 984

  Fly   635 ITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYF 699
            ....                              |...:..|.....:|....
  Rat   985 FLMG------------------------------KGSARRAPFVQEAEDLWLS------------ 1007

  Fly   700 DCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSR 764
                        ||...||:..:.|||:||||||..|.:||||||||:|:|....:||.||||:|
  Rat  1008 ------------PLTMEDLVCYSFQVALGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLAR 1060

  Fly   765 DVYHENVY-RKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSD 827
            |:|.:..| ||  ||.:||:||:|.||:..:|||:|||||||||||:||.:||..|||.|. ..:
  Rat  1061 DIYKDPDYVRK--GSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEE 1123

  Fly   828 LLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI 877
            ..|.|:.|.||:.||..|..:..:|:||||..|..||.||.|...||.::
  Rat  1124 FCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLL 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	8/61 (13%)
		STYKc	475..873	CDD:214568	135/406 (33%)
		PTKc	479..873	CDD:270623	134/402 (33%)
Flt4	NP_446104.2	Ig_2	137..220	CDD:404734
		IgI_VEGFR	230..329	CDD:409448
		Ig strand B	248..252	CDD:409448
		Ig strand C	263..267	CDD:409448
		Ig strand E	293..297	CDD:409448
		Ig strand F	307..312	CDD:409448
		Ig strand G	320..323	CDD:409448
		Ig	331..418	CDD:416386
		Ig strand A	332..337	CDD:409353
		Ig strand A'	342..347	CDD:409353
		Ig strand B	349..360	CDD:409353
		Ig strand C	364..370	CDD:409353
		Ig strand C'	372..375	CDD:409353
		Ig strand D	378..380	CDD:409353
		Ig strand E	382..387	CDD:409353
		Ig strand F	395..403	CDD:409353
		Ig strand G	409..418	CDD:409353
		IG_like	570..663	CDD:214653	21/133 (16%)
		Ig strand B	574..578	CDD:409353	0/3 (0%)
		Ig strand C	587..591	CDD:409353	1/17 (6%)
		Ig strand E	636..640	CDD:409353	1/13 (8%)
		Ig strand F	650..655	CDD:409353	0/4 (0%)
		IGc2	693..755	CDD:197706	20/124 (16%)
		Ig strand B	695..699	CDD:409353	2/6 (33%)
		Ig strand C	708..712	CDD:409353	1/4 (25%)
		Ig strand E	731..735	CDD:409353	0/16 (0%)
		Ig strand F	745..750	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	770..804	CDD:375470	10/39 (26%)
		PKc_like	837..1175	CDD:419665	138/420 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910