DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tor and fgfr4

DIOPT Version :9

Sequence 1:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_571505.1	Gene:	fgfr4 / 100000160	ZFINID:	ZDB-GENE-980526-488	Length:	922	Species:	Danio rerio

Alignment Length:	948	Identity:	231/948 - (24%)
Similarity:	370/948 - (39%)	Gaps:	276/948 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 ICRTESEI--VFQIDWVQ--HSRGTEPA--PNATYIIRV-DAVK---DDNKETALYLSDDNFLIL 136
            :|:.|:..  ..:..||:  .....||.  |:...::.: |.:|   |.|:..|:........:
Zfish   117 VCKAENSAGQATRSAWVEVLSEVSEEPTEEPSEHLLLELGDVLKLRCDTNRPGAVQWFKSGVRV- 180

  Fly   137 PGLESNSTHNITALAMH-GDGSYSLIAKDQTFATLIRGYQPS-KMGAVNLLRFVPQPDD------ 193
               :.|:...|.|..|. .|.:|.   ....:..::||.:.: :...:.:...|...||
Zfish   181 ---QHNARIQIRAAVMEIADVTYE---DSGVYVCMLRGTKEALRNFTITVADAVGSGDDDDEDNG 239

  Fly   194 LHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPL-------EVQFR-----DRKKLYRHTVDN 246
            |..|..|.|     ....|.....|.|::..|::.|       .|:||     ......|...:.
Zfish   240 LDDIGPETE-----NDQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTIRWLKNG 299

  Fly   247 LEFDKQYHVGVRTVNIMNRLESDLQW---LPIAVP------SCLDWYPY-----NYTL----CPP 293
            .||..::.:|    .|..|.:   .|   :...||      ||:....|     .|.|    ..|
Zfish   300 REFRGEHRIG----GIKLRHQ---HWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSP 357

  Fly   294 HK-------PENLTVT---QKQYLPNILA---LNITWAR------PRYLPDNYTLHIFDLFKGGT 339
            |:       |:|.|..   ..|:|..:.:   .:|.|.:      .||.||.  :....:.|.|:
Zfish   358 HRPILQAGLPKNTTAIVGGDAQFLCKVYSDAQPHIQWLKHIEMNGSRYGPDG--IPYVKIVKTGS 420

  Fly   340 ELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSG----LTLDKVHRGVLLSEGNMVKL 400
             ||.:   .....|:..|::..:.....|...|.|..:.|.    |:.:.|.:.|.|.|.....:
Zfish   421 -LNMS---EVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDI 481

  Fly   401 VLFIIVPICCILMLCSLTFCRR----NRSEVQALQMDAKDAKASEFHL----------SLMDSSG 451
            :::....:..::.:..:..||.    :|.....|.:.    |.|:|.|          |...|:.
Zfish   482 IIYASGFLALVMAIVIVVLCRMQVHPSREPFDTLPVQ----KLSKFPLRRQYSVESNSSGKSSAS 542

  Fly   452 LLVTLSANESLE-----VMD-ELEVEP------HSVLLQDVLGEGAFGLVRR----GVYKKRQ-- 498
            |:.....:.|..     ||: ||..:|      .::.|...||||.||.|.|    |:.|:.|
Zfish   543 LMRVARLSSSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDH 607

  Fly   499 ---VAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQN 560
               ||||:|||:..|:|:.....|::::|.:.||.||:.::|..|: ...:.:|:||.|.|||:.
Zfish   608 MATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQ-DGPLYVLVEYASKGSLRE 671

  Fly   561 FLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSS 625
            :||.                           |.|....:
Zfish   672 YLRA---------------------------RRPPGMDY-------------------------- 683

  Fly   626 RCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKK 690
               |:.:|::
Zfish   684 ---TFDVTKV------------------------------------------------------- 690

  Fly   691 RIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSI 755
                              |...|.:.||:..|.|||.|||:||..:.:||||||||||::.|..:
Zfish   691 ------------------PEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVM 737

  Fly   756 KIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPY 820
            |||||||:|.|:..:.|:|: .:|::|:||:|.|:|..:|||.||||||||||::||.||||.||
Zfish   738 KIADFGLARGVHQIDYYKKT-TNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 801

  Fly   821 PSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATN---- 881
            |.:...:|.:||::||||.:|..||.|::..|..||.:||:.||||..|...|..::::.:
Zfish   802 PGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSISDEYL 866

  Fly   882 DVPERLKQLQAATESKLKSCDGLNSKV------EQVPC 913
            |:....:|...:.|....||...|..|      ...||
Zfish   867 DLSTPFEQYSPSCEDTSSSCSSDNDSVFTHDALSTEPC 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tor	NP_476762.1	FN3	199..261	CDD:214495	14/73 (19%)
		STYKc	475..873	CDD:214568	127/406 (31%)
		PTKc	479..873	CDD:270623	126/402 (31%)
fgfr4	NP_571505.1	IG_like	44..135	CDD:214653	4/17 (24%)
		Ig	52..136	CDD:299845	4/18 (22%)
		IG_like	150..224	CDD:214653	13/80 (16%)
		IGc2	156..212	CDD:197706	11/62 (18%)
		Ig2_FGFR	268..352	CDD:143265	18/90 (20%)
		IG_like	273..352	CDD:214653	17/85 (20%)
		IG_like	367..461	CDD:214653	21/99 (21%)
		Ig3_FGFR-2	375..462	CDD:143266	18/92 (20%)
		PTKc_FGFR4	565..877	CDD:133230	132/442 (30%)
		Pkinase_Tyr	578..854	CDD:285015	127/406 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910