DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and CARMIL3

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_612369.3	Gene:	CARMIL3 / 90668	HGNCID:	20272	Length:	1372	Species:	Homo sapiens

Alignment Length:	1368	Identity:	424/1368 - (30%)
Similarity:	642/1368 - (46%)	Gaps:	253/1368 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYL 70
            :||::|.:|::..|.:.. :|.::.||||||..|.|:|||..|..|::|...|||.|:|..|:.|
Human     7 ELTRELQDSIRRCLSQGA-VLQQHHVKLETKPKKFEDRVLALTSWRLHLFLLKVPAKVESSFNVL 70

  Fly    71 DIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLK 135
            :|....:...... :|..:|           ...|:|.....:.|.:...::||:.::.|....
Human    71 EIRAFNTLSQNQI-LVETER-----------GMVSMRLPSAESVDQVTRHVSSALSKVCPGPGC- 122

  Fly   136 YIIRKIDIQPPE--RETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYL 198
             :||:.:...||  |:|..:.|...|...:|  |||||..||.:||::|:..||||.|||||||.
Human   123 -LIRRGNADTPEGPRDTSPNSETSTSTTHSV--CGGFSETYAALCDYNGLHCREEVQWDVDTIYH 184

  Fly   199 SHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELH 263
            :.|.|..||.||.|||.:||..:|:||.||.:|..|....:||..|.||::||.|.:|..||||.
Human   185 AEDNREFNLLDFSHLESRDLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLHTLSKSGSLEELV 249

  Fly   264 LEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKV 328
            |:..||:.||:.||:.....|.:..:..:.||||.|||||..||....         |..|
Human   250 LDNAGLKTDFVQKLAGVFGENGSCVLHALTLSHNPIEDKGFLSLSQQL---------LCFP---- 301

  Fly   329 SKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNS---LKDDITNLHNFLAQPNV 390
             .||.||.||...::.:|:..:..:...|.:.::||.|||||.|.   ..|:...|::||||||.
Human   302 -SGLTKLCLAKTAISPRGLQALGQTFGANPAFASSLRYLDLSKNPGLLATDEANALYSFLAQPNA 365

  Fly   391 LEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNI 455
            |.||||:.||..::.|.||||.||.:||.:||::.||.|.:||:|.||:|||||:|.::|.|:|:
Human   366 LVHLDLSGTDCVIDLLLGALLHGCCSHLTYLNLARNSCSHRKGREAPPAFKQFFSSAYTLSHVNL 430

  Fly   456 AGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDA 520
            :..|||:|||:.||.||:.|...:.|:|||||..|.:.||..|:..:..|..:.|||:|||..|:
Human   431 SATKLPLEALRALLQGLSLNSHLSDLHLDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNGFDS 495

  Fly   521 ELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLH 585
            :|..::.|:.||.|::.|.|.::. .:|.|.:..::..||.|||::|..|..|.:::::||....
Human   496 DLLTLVPALGKNKSLKHLFLGKNF-NVKAKTLEEILHKLVQLIQEEDCSLQSLSVADSRLKLRTS 559

  Fly   586 DFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHN 650
            ..|||||||..|.|:|:|||.|.|:||::|:||||||:.||||..|:|..:..|:.||..|||.|
Human   560 ILINALGSNTCLAKVDLSGNGMEDIGAKMLSKALQINSSLRTILWDRNNTSALGFLDIARALESN 624

  Fly   651 HSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQLV 715
            |::|.:.|||.||:...:|.|::|:.|.:|:|..|.||.:.......|.||||.|.:.||..|::
Human   625 HTLRFMSFPVSDISQAYRSAPERTEDVWQKIQWCLVRNNHSQTCPQEQAFRLQQGLVTSSAEQML 689

  Fly   716 DKLVAETQDTISLAK-----GGSESASAVQRLITDAENCKQLMPKLQE---AVRNESHPIEMKMT 772
            .:|....|:.:...:     ...:.....:.||.||:|.:.|.|.|.|   .:.|:. |:..::.
Human   690 QRLCGRVQEEVRALRLCPLEPVQDELLYARDLIKDAKNSRALFPSLYELGHVLANDG-PVRQRLE 753

  Fly   773 RVASELSYTIKSYLEETMETMMRTGIEQCP----------KTLGNQIVVQDLRKALAERLVVPEE 827
            .||||:|..:...|:..:|:|:....|.||          |.|.|          :|||:.||..
Human   754 SVASEVSKAVDKELQVILESMVSLTQELCPVAMRVAEGHNKMLSN----------VAERVTVPRN 808

  Fly   828 FLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPS---VLLDEPQ 889
            |::..||..||.:|.||:.|::.|:...::....||:|:.|  |.....:|...:   .|.|.|.
Human   809 FIRGALLEQAGQDIQNKLDEVKLSVVTYLTSSIVDEILQEL--YHSHKSLARHLTQLRTLSDPPG 871

  Fly   890 TPDIVRSRSSHDADGLIIRPGGRG-------SILPKLGLESPTKLEYLNLATPHLPTKRRSLAKK 947
            .|...:..||.          |||       :...:||....|           :..|::...:|
Human   872 CPGQGQDLSSR----------GRGRNHDHEETTDDELGTNIDT-----------MAIKKQKRCRK 915

  Fly   948 VRPQSVVENLSLGHFPDLLESPSSHRSNSQL-SARAAAGAAALVGAANMTDSIAVDDGGVDECCD 1011
            :||.|.            ..|.|.....||| :.....|..:.:|.:..|.|         ...:
Human   916 IRPVSA------------FISGSPQDMESQLGNLGIPPGWFSGLGGSQPTAS---------GSWE 959

  Fly  1012 SITELPSASFQLQHLVKGRPKRAKTR--APTRPLV----TTECAGGSREIGEGLEHFFR------ 1064
            .::|||:..::|:|..:|||:..:|.  .|.||.:    |.:..|.:..:.||||.||.
Human   960 GLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRPSMPAPGTRQENGMATRLDEGLEDFFSRRVLEE 1024

  Fly  1065 ---------------------------------------------PGSVTPTTLTPLVSPTSEEC 1084
                                                         |||.|...|.|...|.....
Human  1025 SSSYPRTLRTVRPGLSEAPLPPLQKKRRRGLFHFRRPRSFKGDRGPGSPTTGLLLPPPPPPPPTQ 1089

  Fly  1085 SSLSFVDSPTMSRDGNGHMTSEETTPIL---------EERRPIKLERQSP--------------- 1125
            .|....|.|::..:.:...:.||.:.:|         ..||.:..|...|
Human  1090 ESPPSPDPPSLGNNSSPCWSPEEESSLLPGFGGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRV 1154

  Fly  1126 -------LLKSASWA----------TRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATGAE 1173
                   |.::..|:          .:..||...:|      |:|     ..:.||||.......
Human  1155 HGVALPGLERAKGWSFDGKREGPGPDQEGSTQAWQK------RRS-----SDDAGPGSWKPPPPP 1208

  Fly  1174 ETSMPSSNLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEP 1238
            :::.||   ..|..|.:.|...:.:|..:|:.                    |.|.|.|..|.|.
Human  1209 QSTKPS---FSAMRRAEATWHIAEESAPNHSC--------------------QSPSPASQDGEEE 1250

  Fly  1239 KAG 1241
            |.|
Human  1251 KEG 1253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	137/320 (43%)
		leucine-rich repeat	289..331	CDD:275381	13/41 (32%)
		leucine-rich repeat	332..352	CDD:275381	6/19 (32%)
		leucine-rich repeat	364..389	CDD:275380	13/27 (48%)
		leucine-rich repeat	391..417	CDD:275380	14/25 (56%)
		leucine-rich repeat	418..449	CDD:275380	17/30 (57%)
		LRR_RI	441..>656	CDD:238064	95/214 (44%)
		leucine-rich repeat	450..467	CDD:275380	9/16 (56%)
		leucine-rich repeat	468..503	CDD:275380	15/34 (44%)
		leucine-rich repeat	508..534	CDD:275380	11/25 (44%)
		leucine-rich repeat	535..564	CDD:275380	7/28 (25%)
		leucine-rich repeat	570..596	CDD:275380	11/25 (44%)
		leucine-rich repeat	597..618	CDD:275380	11/20 (55%)
		CARMIL_C	797..1108	CDD:292619	84/388 (22%)
CARMIL3	NP_612369.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..151		6/24 (25%)
		LRR_RI	185..501	CDD:238064	141/329 (43%)
		LRR 1	244..264		10/19 (53%)
		leucine-rich repeat	245..273	CDD:275381	12/27 (44%)
		LRR 2	274..295		11/20 (55%)
		leucine-rich repeat	275..303	CDD:275380	13/41 (32%)
		LRR 3	303..323		7/19 (37%)
		leucine-rich repeat	304..335	CDD:275380	7/30 (23%)
		LRR 4	335..357		9/21 (43%)
		leucine-rich repeat	336..365	CDD:275380	14/28 (50%)
		LRR_RI	339..600	CDD:238064	120/261 (46%)
		LRR 5	365..385		9/19 (47%)
		leucine-rich repeat	366..391	CDD:275380	14/24 (58%)
		LRR 6	392..413		10/20 (50%)
		leucine-rich repeat	393..420	CDD:275380	15/26 (58%)
		LRR 7	424..444		9/19 (47%)
		leucine-rich repeat	425..452	CDD:275380	14/26 (54%)
		leucine-rich repeat	453..479	CDD:275380	10/25 (40%)
		LRR 8	455..475		10/19 (53%)
		leucine-rich repeat	480..509	CDD:275380	12/28 (43%)
		LRR 9	482..501		8/18 (44%)
		LRR 10	509..530		5/21 (24%)
		leucine-rich repeat	544..570	CDD:275381	11/25 (44%)
		leucine-rich repeat	571..593	CDD:275381	12/21 (57%)
		CARMIL_C	778..1063	CDD:292619	73/338 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..900		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	970..1003		10/32 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1372		43/264 (16%)
		Necessary for localization at the cell membrane. /evidence=ECO:0000269\|PubMed:26578515	1040..1073		2/32 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142531
Domainoid	1	1.000	122	1.000	Domainoid score	I5651
eggNOG	1	0.900	-	-		E1_KOG4242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I657
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208951at2759
OrthoFinder	1	1.000	-	-		FOG0002311
OrthoInspector	1	1.000	-	-		otm40610
orthoMCL	1	0.900	-	-		OOG6_103674
Panther	1	1.100	-	-	O	PTHR24112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3852
SonicParanoid	1	1.000	-	-		X2004
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790