DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and Carmil1

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_011242635.1	Gene:	Carmil1 / 68732	MGIID:	1915982	Length:	1430	Species:	Mus musculus

Alignment Length:	1556	Identity:	528/1556 - (33%)
Similarity:	794/1556 - (51%)	Gaps:	260/1556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHY 69
            |.:.::|.||:|.::||..||.||..||||.|||:.||:|||.|..|.:||||::|:|:|..|.|
Mouse     6 SDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPSKLELTFSY 70

  Fly    70 LDIVGVESKKSTHFSIVTN--DRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTV 132
            |:|.||...|.....:.|.  :.....|:..|...              :|..:.:.:::|||.:
Mouse    71 LEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSE--------------VLAHIGTCLRRIFPGL 121

  Fly   133 -PLKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTI 196
             ||: |::|:.::|.||.......:........|||||||..|||:||:.|..|:|||.||||||
Mouse   122 SPLR-IMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYKEEVQWDVDTI 185

  Fly   197 YLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEE 261
            ||:.|||.|||:||.|||.:||:.|::|||||.:|..|.:..::||.:..|:||.|:.||..|||
Mouse   186 YLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEE 250

  Fly   262 LHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIA 326
            |.||..|||.||..||:.::..|.|..:.||:|:.|.:||:|.|||...|              |
Mouse   251 LVLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQF--------------A 301

  Fly   327 KVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLK-DDITNLHNFLAQPNV 390
            |:.|||..|.|:...|:.||||.:..||:.|...:::||:||||||:|: ||:::::|||||||.
Mouse   302 KLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNT 366

  Fly   391 LEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNI 455
            :.||||::|:.:||.:..||||||...||.||:|.:.||.:||||:||||||||:|:.:|..:|:
Mouse   367 IVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINL 431

  Fly   456 AGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLG----AQGAHVLESCIHGVRVLQSLDISDN 516
            :|.||..|.||.||||||||.|..|:.||||:..||    :.||.|||.||..:..:.|||||||
Mouse   432 SGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDN 496

  Fly   517 NLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLK 581
            .|:::|:.::..:|||.||:.|.|.::...||.|::.||:|.||.:||.:|.||..|.|:::|||
Mouse   497 GLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLK 561

  Fly   582 HDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYA 646
            .::...|||||||.||.|:|||||.|||:||::||||||||.:|||:..|||.:|.||:.||..|
Mouse   562 AEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVA 626

  Fly   647 LEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSST 711
            :|.|:::|.:|.|::|.|..||::|:||:..::|::..|.||....|....|.:|||.|.:.|:|
Mouse   627 MEKNYTLRFMPIPMYDAAQALKTNPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTT 691

  Fly   712 HQLVDKLVAETQDTIS--LAKGG---SESASAVQRLITDAENCKQLMPKLQE--------AVRNE 763
            .|::|::..:.||.::  .|.||   .|...|.:||:.||:|.|.|:|.|..        |....
Mouse   692 QQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLS 756

  Fly   764 SHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEF 828
            |.||:..:..:|.|::..:...|::.:|:|:......||..:....:.|||..|..|::.:|..|
Mouse   757 SSPIQETLESMAGEVTRVVDEQLKDLLESMVDAAETLCPNVMRKAHIRQDLIHASTEKISIPRTF 821

  Fly   829 LQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDE-PQTPD 892
            ::..||..:|.:|:||:.|::.::|:.:|||..||:|::|:...|  .:|...|.|... ||..|
Mouse   822 VKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHR--KLANHFSRLNKSLPQRED 884

  Fly   893 IVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLA--------TPHLPTKRRSL-AKKV 948
            :       :.:.:..:|..| :||....|....:||.|:..        ||  .:||:|: ::.:
Mouse   885 L-------EVELVEEKPVKR-AILTVEDLTEVERLEDLDTCMTLCCTSMTP--KSKRKSIHSRML 939

  Fly   949 RPQSVVENL------SLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVD 1007
            ||.|....:      :|...|..:|.|...      |.|....::.|
Mouse   940 RPVSRAFEMEFDLDKALEEVPIHIEDPPFP------SVRQEKRSSGL------------------ 980

  Fly  1008 ECCDSITELPS-ASFQLQHLVKGRPKRAKTRAPTRPLVTT--------ECAGGSREIGEGLEHFF 1063
                 |:|||| ...:|:|..|.||||.|.:.||:..|.|        |..|....:.||::.||
Mouse   981 -----ISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCTISILPQDGEQNGLMGRVDEGVDEFF 1040

  Fly  1064 RPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQS--PL 1126
                      |..|  |..:|...|       ||..:.|...|.     :|::.....|..  .|
Mouse  1041 ----------TKKV--TKMDCKRSS-------SRSSDAHELGEG-----DEKKKRDSRRSGFLNL 1081

  Fly  1127 LKSASWATRSRS--------TDNLEKYSPLVGRKSPLV---KMRTEGGPGSGSATGAEETSMPSS 1180
            :||     ||||        |:.|.  ||....:||.|   :...:....:|:....||...|..
Mouse  1082 IKS-----RSRSERPPTVLMTEELS--SPKGAMRSPPVDTTRKEIKAAEHNGAPDRTEEIKTPEP 1139

  Fly  1181 NLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLI 1245
              |:....|:..|:..|||..|...|...|.| .|:|:|......|:.|   ...::.|.|.|:|
Mouse  1140 --LEEGPAEEAGRAERSDSRGSPQGGRRYVQV-MGSGLLAEMKAKQERR---AACAQKKLGNDVI 1198

  Fly  1246 TGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITP--------- 1301
            :.:.::..|..| ::||.            ..::..:.||:..:..|.|     ||
Mouse  1199 SQDPSSPVSCNT-ERLEG------------GATVPKLQPGLPEARFGSG-----TPEKNAKAEPR 1245

  Fly  1302 --GGALEKKSVRELAAGLNRMELPLKP--------PVMPRTLLNATSVRTSTSSTGSTSNSVS-- 1354
              ||...:.|.....:....::.| ||        |..|||......  |..|.:|.:|..|:
Mouse  1246 VDGGCRSRSSSSMPTSPKPLLQSP-KPSPSARPSIPQKPRTASRPED--TPDSPSGPSSPKVALL 1307

  Fly  1355 --VSSSTNANTSMTVLNQSQTRSRIVSST-----------SSTDSTE-------------TITE- 1392
              :....:::......|.||:..|..|..           |..||.:             .|.|
Mouse  1308 PPILKKVSSDKERDGQNSSQSSPRSFSQEVVQRGDYFKRHSDHDSGKPSSRGKRSSKLYFAIAEE 1372

  Fly  1393 -------RSTTSTSSSSSS-----SYEKQHAKACANLISNEILSMRNGQLGAKSGSCAESG 1441
                   |.:..|::|..|     .|::|..::          |.::|..|:|   |::||
Mouse  1373 EANAPGYRKSQPTNASRRSWGPAQEYQEQKQRS----------SGKDGHQGSK---CSDSG 1420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	158/322 (49%)
		leucine-rich repeat	289..331	CDD:275381	13/41 (32%)
		leucine-rich repeat	332..352	CDD:275381	8/19 (42%)
		leucine-rich repeat	364..389	CDD:275380	16/25 (64%)
		leucine-rich repeat	391..417	CDD:275380	13/25 (52%)
		leucine-rich repeat	418..449	CDD:275380	20/30 (67%)
		LRR_RI	441..>656	CDD:238064	113/218 (52%)
		leucine-rich repeat	450..467	CDD:275380	7/16 (44%)
		leucine-rich repeat	468..503	CDD:275380	22/38 (58%)
		leucine-rich repeat	508..534	CDD:275380	12/25 (48%)
		leucine-rich repeat	535..564	CDD:275380	11/28 (39%)
		leucine-rich repeat	570..596	CDD:275380	13/25 (52%)
		leucine-rich repeat	597..618	CDD:275380	14/20 (70%)
		CARMIL_C	797..1108	CDD:292619	86/335 (26%)
Carmil1	XP_011242635.1	Carm_PH	38..119	CDD:375405	28/94 (30%)
		LRR_RI	<229..373	CDD:393385	70/157 (45%)
		leucine-rich repeat	248..275	CDD:275378	14/26 (54%)
		leucine-rich repeat	278..305	CDD:275378	13/40 (33%)
		leucine-rich repeat	307..338	CDD:275380	11/30 (37%)
		leucine-rich repeat	339..359	CDD:275380	11/19 (58%)
		leucine-rich repeat	367..393	CDD:275380	13/25 (52%)
		leucine-rich repeat	394..425	CDD:275380	20/30 (67%)
		LRR_RI	417..>634	CDD:393385	112/216 (52%)
		leucine-rich repeat	426..453	CDD:275380	16/26 (62%)
		leucine-rich repeat	454..487	CDD:275380	14/32 (44%)
		leucine-rich repeat	488..514	CDD:275380	12/25 (48%)
		leucine-rich repeat	515..541	CDD:275380	10/25 (40%)
		leucine-rich repeat	550..576	CDD:275380	13/25 (52%)
		CARMIL_C	790..1085	CDD:374283	91/364 (25%)
		PHA02682	1119..>1324	CDD:177464	48/231 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832379
Domainoid	1	1.000	206	1.000	Domainoid score	I2915
eggNOG	1	0.900	-	-		E1_KOG4242
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9757
Inparanoid	1	1.050	702	1.000	Inparanoid score	I662
Isobase	1	0.950	-	0	Normalized mean entropy	S6233
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208951at2759
OrthoFinder	1	1.000	-	-		FOG0002311
OrthoInspector	1	1.000	-	-		otm42686
orthoMCL	1	0.900	-	-		OOG6_103674
Panther	1	1.100	-	-	O	PTHR24112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3852
SonicParanoid	1	1.000	-	-		X2004
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740