DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRR and RNH1

DIOPT Version :9

Sequence 1:NP_001260788.1 Gene:LRR / 35715 FlyBaseID:FBgn0033212 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_002930.2 Gene:RNH1 / 6050 HGNCID:10074 Length:461 Species:Homo sapiens


Alignment Length:339 Identity:87/339 - (25%)
Similarity:135/339 - (39%) Gaps:61/339 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 IVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRS-MWLEELHLEALGLRWDFLNKLSISVITN 284
            :.|.|.....|:.|..::..::...:..:...||.| ..||.|.||:.|:..|  |...:..|..
Human   162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD--NCRDLCGIVA 224

  Fly   285 SNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQ 349
            |..::|.:.|..|.:.|.|.:.||       .|.:|       .|..|..|.:..||:|:||...
Human   225 SKASLRELALGSNKLGDVGMAELC-------PGLLH-------PSSRLRTLWIWECGITAKGCGD 275

  Fly   350 MSHSLTLNQSISNSLTYLDLSGNSLKDDITN-LHNFLAQPNV-LEHLDLASTDITLENLFGALLR 412
            :...|...:|:..    |.|:||.|.|:... |...|.:|.. ||.|.:.|...|         .
Human   276 LCRVLRAKESLKE----LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFT---------A 327

  Fly   413 GCATH----------LAHLNVSHNSFSTKKGKEI------PPSFKQFFTSTFSLKHLNIAGCKLP 461
            .|.:|          |..|.:|:|.......:|:      |.|.         |:.|.:|.|.:.
Human   328 ACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSV---------LRVLWLADCDVS 383

  Fly   462 MEALKNLLLGLACNESTAGLYLDLSSNTLGAQG-AHVLESCIHGVRVLQSLDISDNNLDAELAPV 525
            ..:..:|...|..|.|..  .||||:|.||..| ..::||......:|:.|.:.|.....|:...
Human   384 DSSCSSLAATLLANHSLR--ELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDR 446

  Fly   526 LTAISKN-PSIRTL 538
            |.|:.|: ||:|.:
Human   447 LQALEKDKPSLRVI 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRNP_001260788.1 LRR_RI 198..516 CDD:238064 79/314 (25%)
leucine-rich repeat 289..331 CDD:275381 10/41 (24%)
leucine-rich repeat 332..352 CDD:275381 7/19 (37%)
leucine-rich repeat 364..389 CDD:275380 8/25 (32%)
leucine-rich repeat 391..417 CDD:275380 6/25 (24%)
leucine-rich repeat 418..449 CDD:275380 7/36 (19%)
LRR_RI 441..>656 CDD:238064 28/100 (28%)
leucine-rich repeat 450..467 CDD:275380 4/16 (25%)
leucine-rich repeat 468..503 CDD:275380 14/35 (40%)
leucine-rich repeat 508..534 CDD:275380 7/26 (27%)
leucine-rich repeat 535..564 CDD:275380 1/4 (25%)
leucine-rich repeat 570..596 CDD:275380
leucine-rich repeat 597..618 CDD:275380
CARMIL_C 797..1108 CDD:292619
RNH1NP_002930.2 2 X 5 AA tandem repeats of S-L-D-I-Q 2..11
LRR_RI 6..325 CDD:238064 49/182 (27%)
leucine-rich repeat 6..29 CDD:275380
LRR 1 20..48
leucine-rich repeat 30..57 CDD:275380
LRR 2 49..76
leucine-rich repeat 58..86 CDD:275380
LRR 3 77..105
leucine-rich repeat 87..114 CDD:275380
LRR 4 106..133
leucine-rich repeat 115..143 CDD:275380
LRR 5 134..162 87/339 (26%)
leucine-rich repeat 144..171 CDD:275380 2/8 (25%)
LRR 6 163..190 4/26 (15%)
leucine-rich repeat 172..200 CDD:275380 5/27 (19%)
LRR 7 191..219 11/29 (38%)
leucine-rich repeat 201..228 CDD:275380 10/28 (36%)
LRR 8 220..247 7/26 (27%)
leucine-rich repeat 229..257 CDD:275380 10/41 (24%)
LRR 9 248..276 11/41 (27%)
leucine-rich repeat 258..278 CDD:275380 7/19 (37%)
LRR 10 277..304 8/30 (27%)
leucine-rich repeat 286..314 CDD:275380 9/31 (29%)
LRR 11 305..333 8/36 (22%)
leucine-rich repeat 315..338 CDD:275380 7/31 (23%)
LRR 12 334..361 4/26 (15%)
LRR_RI 340..367 CDD:197686 5/26 (19%)
leucine-rich repeat 343..367 CDD:275380 5/23 (22%)
LRR 13 362..390 6/36 (17%)
leucine-rich repeat 372..399 CDD:275380 7/26 (27%)
LRR 14 391..418 11/28 (39%)
LRR_RI 397..424 CDD:197686 12/28 (43%)
LRR 15 419..447 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142532
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.