DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and CG31635

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001260135.1	Gene:	CG31635 / 33928	FlyBaseID:	FBgn0051635	Length:	1805	Species:	Drosophila melanogaster

Alignment Length:	1731	Identity:	318/1731 - (18%)
Similarity:	557/1731 - (32%)	Gaps:	589/1731 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 QYACMCDFHGVPYREEVAWDVDTIYLSH--------DTRVLNLRDFDHLE--------------- 214
            ||...|..|.....|.|...:.|:.|:.        ..:.|...|.:.||
  Fly   245 QYQQSCKKHNTQPLESVVDHLRTLDLNQARQPLLPLKAKELTANDCEALEEIFKRIQYTCIDLSE 309

  Fly   215 ----PKDLMAIVSALEYNTFFRGLKAAHMR--LSHETLERILHVLKRSMWLEELHLEA-----LG 268
                ...|||:...:||......|..::.:  ::....|...::::||..|:.|:.|:     ||
  Fly   310 CTLDESSLMALFQMIEYYEAANELDISYNKAEMTKRCWELCAYMVERSQELQLLNAESNPITKLG 374

  Fly   269 LRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLC 333
            .  |.|.:    .:.:||  :.|:.|.|           |.|.|..:...:..||.....:|.|.
  Fly   375 A--DSLGR----ALGSSN--LHTLKLEH-----------CGLRGAPLVNLLSFAGRGLYQNKRLK 420

  Fly   334 KLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKDDITNLHNFLAQPNVLEHLDLAS 398
            :|.:.:..|.......::..|..|    :||..:|:|.|:::::..   .:|.|..:|:     |
  Fly   421 ELWVGYNDLDCVDAQHIADMLRYN----HSLELIDISNNNIRNEGV---MYLVQALILQ-----S 473

  Fly   399 TDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPME 463
            |:  ||...|||.|   |....::...:...|:..:.||||     ||:.:.:..:....:||
  Fly   474 TE--LERRMGALKR---TRAIEVDECVSPMETEPPEAIPPS-----TSSTTNQAKDFVDGELP-- 526

  Fly   464 ALKNLLLGLACNESTA-----GLYLDLSS-----NTLGAQGAHVLESCIH---GVRVLQSL---- 511
            |.:..:|.....|:|:     |:.:||.:     ||  ......:.:|..   |..:|..|
  Fly   527 AHEASILETTSEEATSTDPAVGVLVDLENDNDDENT--EDTVRTVRNCNQNGSGQSMLDKLLSMN 589

  Fly   512 -----------------------DISD--NNL-----------DAELAPVLTAISKNPSIRTLHL 540
                                   |||:  |.:           :.|:||.:.:.|...|......
  Fly   590 SESSSEEAPSNISTDTLAACCSEDISEISNEIYEPNAVKQPTAEGEVAPAMISSSPMESESVAVA 654

  Fly   541 TRSLTGMKPKH--------------IPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINAL 591
            :.::..:.|.|              |.|..:|  ..::.::..:...:::.|...:..:...|.
  Fly   655 SATMEPLSPAHQQQQCSQNERNLCDITPSTEA--KTVEPNESCVQNNIINNNNNNNANNSHNNT- 716

  Fly   592 GSNQSLQ----------------KLDISGNFMGDVGARLLAKALQ----INNRL-------RTIY 629
             :|.::|                :|||.....|...|.:.....:    ||...       |.:.
  Fly   717 -NNNTIQLPSEAGASAILSVVPPQLDIENIPSGSSPAAIFEVTAEESDCINGSAVAGAAGSRPLD 780

  Fly   630 MDKNGVTLQGYADIVYALEHNHSMRTIPFPVF------DIAPHLKSHPDKTDAVMR--KMQELLQ 686
            ::||....:.:.|       .||..:    .|      ||:.||.....:...::.  ::.::.:
  Fly   781 VNKNAKAGEDFED-------THSTDS----AFESASEGDISRHLPDELSRLSVLLESTRLDDMTK 834

  Fly   687 RNCNGLKRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSESASAVQRL--------I 743
            ..| |::.||         ....||..|   |.|:...|::    .:....|:::|        :
  Fly   835 EMC-GIETAT---------IATESTECL---LAAQEAATLT----PTPVVPALEKLENAFPPPKV 882

  Fly   744 TDAENC----KQLMPKLQEAVRNESHP---------IEMKMTRVASELSY----------TIKSY 785
            |.||.|    |:|.|....::.....|         ..:.:.|..|..:|          :..|.
  Fly   883 TIAEECLLKDKELSPSSYPSLSPAPTPPPPSTSPGGASLGLRRTESSCAYLNQSSRNRSQSSDSL 947

  Fly   786 LEETMETMMRTG----------------IEQCPK--------------------------TLGNQ 808
            ..||....|.:|                .|:..|                          ||.|.
  Fly   948 CSETSLDGMSSGASNNSVSSTASADPKFAEKLTKNDTLSRRQLAEATLEANRSPSGLKALTLWNN 1012

  Fly   809 IVVQDLRKALAERL--VVPEEFLQI---CLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEAL 868
            .:.:|...|:||.|  .:..|.|.|   ||.|:..|.|.:           :::...|...|...
  Fly  1013 NLSKDCAPAVAELLQKTISLELLNIGKNCLSNDFVSTIKD-----------SLTKNTTLTTLGLQ 1066

  Fly   869 TRYRRGMGIAESPSVLL----DEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEY 929
            :.:....||....|:|.    .:.|..||..::...::..:|.........|.::.:....|
  Fly  1067 SAHLNAKGIETLASILTFGGNSKLQRIDIRDNKLEVESLNIIAEVLKSNKTLTQIDINDEPK--- 1128

  Fly   930 LNLATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDL--------LESPSSHRSNSQLSARAAAGA 986
             .|..|.:|      ...|.|.|.:...|:|....|        :.|..|.....|....|...|
  Fly  1129 -RLTLPIVP------IVNVIPPSPLPQESIGSDAHLDYTRVLGTVRSLCSRNEKRQAQELAEKTA 1186

  Fly   987 AALVGAANMTDSI--AVDDGG-----------------VDECCDSITELPSASFQLQHLVKGRPK 1032
            ..:.|.:|:..|:  ....||                 ||....::|...:|:
  Fly  1187 NMVGGGSNVGGSLPGIRCRGGYYLGSRKISLTCHSRPIVDAATGTVTATSTAT------------ 1239

  Fly  1033 RAKTRAPTRPLVTTECAGGSREIGEGLEHFFRPGSVTPTT---------------LTPLVSP--- 1079
            .|.|..|| |....|...|.|....|..    |.:::|::               .:||:||
  Fly  1240 AAATALPT-PTALLEVKRGPRLRSPGPS----PPTISPSSSPNRSRFHVSRVAEVASPLISPLAQ 1299

  Fly  1080 --------TSEECSSLSFVDSPTMSR--------------------------------------- 1097
                    ::..|.|:..:.||:.|:
  Fly  1300 HPPPHTPRSASSCMSIPTIGSPSGSQNSLNAVGALPTSSSLPAMASVTSSTQTIKRLSVSPRSRF 1364

  Fly  1098 -------DGNGHMTSEETTPILEERRPIKLERQSPLLKSA------SWATRS------------- 1136
                   |....|.:.:..||.....||.|. .:|:||||      |.|..:
  Fly  1365 HVSRIYEDPQVPMANRQMPPITPHTPPIDLP-PTPMLKSARKAVLLSEAVEAAAAAVPVSSVVIV 1428

  Fly  1137 RSTDNLE-----KYSPLVGRK-------SPLVKMRTEGGPGSGSATGAEETSMPSSNLLKATARE 1189
            .|:||::     |...:.|:|       ||.....:...|||.|       |..|||...:|:
  Fly  1429 ESSDNIDAHISTKAVEVTGQKVSPHLTISPTSSHSSSTSPGSSS-------SGSSSNCNGSTS-- 1484

  Fly  1190 DKTRSPSSDSIKSHAA------------GEGSV-IVKTGNGIL----------RTPIVLQKPRPW 1231
              |.:..:||:.|...            |:..: :.|...|::          ..|::  |..|.
  Fly  1485 --TSTDVTDSVASSGPEVPQRICPLAVFGDNDITLTKESAGVVALSAAAAANNTNPVL--KSEPE 1545

  Fly  1232 SVVGSEPKAGGDLITGNGNADSSK----------TTPDKL------------EEDDVEIVTFGNT 1274
            |:..:||.:         ||..::          :..|||            :...:..|...||
  Fly  1546 SLPPAEPVS---------NAPQTRARKTSWIANPSAVDKLLTIFNIGSSPEPKASQISHVPAANT 1601

  Fly  1275 CSGSIVGITPGIALSTSGGGS--IVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNAT 1337
            .:.|....|   |.|..||.|  |....|..::.:|:.....|.                 |..:
  Fly  1602 ITNSSQNAT---AASVVGGDSSTITNSNPILSVARKTAPASWAS-----------------LTGS 1646

  Fly  1338 SVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETITERSTTSTSSSS 1402
            ::..::.:|.|::.:.|.|....|:..:...::...|..|..:.|...:|.:...:|..||.:|:
  Fly  1647 NISNASQNTASSTETGSSSFLDTASRQLRDFSKQVFRQNISFNNSGEQATPSAPPQSELSTGTSA 1711

  Fly  1403 SSSYEKQHAKAC-------------------ANLISNEILS-----MRNGQLGAKSGSCAESGGV 1443
            |||.|......|                   .:.|:.|.|.     .|...:..|:.:..|.|.:
  Fly  1712 SSSTESPSPPECNAAYIPLSLKRQLKENISPEHTINEETLHTLQKLSRAEDVALKAEAVTELGDI 1776

  Fly  1444 KRIAGKEISTLFEETLVEELQQSMATRRGFRDSTYTKEDVV 1484
            :.:...|::   :..|.|:.||         |...|..:||
  Fly  1777 EIVMHSEVA---DCVLPEDKQQ---------DQEETVSNVV 1805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	79/393 (20%)
		leucine-rich repeat	289..331	CDD:275381	8/41 (20%)
		leucine-rich repeat	332..352	CDD:275381	3/19 (16%)
		leucine-rich repeat	364..389	CDD:275380	6/24 (25%)
		leucine-rich repeat	391..417	CDD:275380	9/25 (36%)
		leucine-rich repeat	418..449	CDD:275380	7/30 (23%)
		LRR_RI	441..>656	CDD:238064	48/308 (16%)
		leucine-rich repeat	450..467	CDD:275380	3/16 (19%)
		leucine-rich repeat	468..503	CDD:275380	9/44 (20%)
		leucine-rich repeat	508..534	CDD:275380	10/65 (15%)
		leucine-rich repeat	535..564	CDD:275380	5/42 (12%)
		leucine-rich repeat	570..596	CDD:275380	3/25 (12%)
		leucine-rich repeat	597..618	CDD:275380	6/36 (17%)
		CARMIL_C	797..1108	CDD:292619	76/460 (17%)
CG31635	NP_001260135.1	leucine-rich repeat	265..292	CDD:275380	4/26 (15%)
		LRR_RI	276..>469	CDD:238064	43/218 (20%)
		leucine-rich repeat	293..329	CDD:275380	7/35 (20%)
		leucine-rich repeat	330..359	CDD:275380	4/28 (14%)
		leucine-rich repeat	360..386	CDD:275380	7/31 (23%)
		leucine-rich repeat	387..418	CDD:275380	8/41 (20%)
		leucine-rich repeat	419..446	CDD:275380	5/30 (17%)
		LRR_RI	<961..>1127	CDD:238064	29/176 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24112
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030