DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and Carmil2

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_038954145.1	Gene:	Carmil2 / 307797	RGDID:	1562390	Length:	1452	Species:	Rattus norvegicus

Alignment Length:	1423	Identity:	401/1423 - (28%)
Similarity:	610/1423 - (42%)	Gaps:	269/1423 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RVYLLSAKVPTKIECHFHYLDIVGV---ESKKSTHFSI-----VTNDRPYSFVTTGDAGNFSSVR 107
            |.|||...:|.:::|.|.||::..:   |:.....|.:     :..:.|      |.|......:
  Rat   107 RAYLLHTCLPLRVDCTFSYLEVQAMALQETPPRVTFELESLPKLVLEFP------GVAALEQLAQ 165

  Fly   108 HNHLLNADVILTDLASAIKQIFPTVPLKYIIRK---------IDIQPPERETIFSEEFRPSDPRN 163
            |            :|:|||::||...|..:.||         ::...|...|:      ||
  Rat   166 H------------VAAAIKKVFPRSTLGKLFRKPTPSSLLARLEKSHPLESTV------PS---- 208

  Fly   164 VGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYN 228
             .|||||...|..:||::|.|:|||:.|||||||.....|...|.||.||..:||...|:||.||
  Rat   209 -SPCGGFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFCLGDFSHLGSRDLALSVAALSYN 272

  Fly   229 TFFRGLKAAHMRLSHETLERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTID 293
            .:||.|....|:||.|..|:|||:..:|.:||||.||..|||.||:.:|:.::..:.|..:|.:.
  Rat   273 LWFRRLSCMDMKLSLEVSEQILHMTSQSSYLEELVLETCGLRGDFVRRLAQALAGHFNSGLRELS 337

  Fly   294 LSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQ 358
            ||.|:::|:|.::|.       :...|..|       .|.||.||..|||.:|:..:..:|..|.
  Rat   338 LSGNLLDDRGMATLS-------RHLEHCPG-------ALRKLCLAQTGLTPRGMRALGRALATNA 388

  Fly   359 SISNSLTYLDLSGN----SLKDDITNLHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLA 419
            :..::||:||||||    ....|...|:.||::||||.:|:||.||..|..||.||..||..:|.
  Rat   389 TFDSTLTHLDLSGNPGALGASQDGGGLYTFLSRPNVLAYLNLAGTDTALGMLFMALSGGCCANLT 453

  Fly   420 HLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLD 484
            ||..|.|.||..|.:.:|.:.::|......|:||.:||||||.|||:.||.|||.|.....|:||
  Rat   454 HLEASRNIFSRTKSQAVPDALQRFLGGARMLRHLGLAGCKLPPEALRALLDGLALNTQIHDLHLD 518

  Fly   485 LSSNTLGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKP 549
            ||:..|.:.||.|::..:.....|.|||:|||...:::..::.||.::.|::.:.|.|:......
  Rat   519 LSACELRSVGAQVIQDLVCDAGALSSLDLSDNGFGSDMVTLVLAIGRSRSLKHVALGRNFNVRCK 583

  Fly   550 KHIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARL 614
            :.:..|:..:|.|:|.||.||..|.::|::||......|.|||:|..|..||||||.:||.||::
  Rat   584 ETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKQGASVLIRALGTNPKLSVLDISGNAIGDTGAKM 648

  Fly   615 LAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMR 679
            |||||::|.|||::..|:|..:..|..|:..|||.|||::::|.|:.||....:|.|:.|...:.
  Rat   649 LAKALRVNTRLRSVIWDRNNTSALGLLDVAEALEQNHSLKSMPLPLNDITQAHRSRPELTARAVH 713

  Fly   680 KMQELLQRNCNGLKRATGQGFR---LQHGFMLSSTHQLVDKLVAETQDTISL--AKGGSESASAV 739
            ::|..|.||    .||.....|   ||...::|...:.|::|....|:.:.|  ...|.:...||
  Rat   714 QIQACLWRN----NRADSTSDRKPCLQPLGLISDHSEQVNELCQSVQEHVELLGCGAGPQGEVAV 774

  Fly   740 QR---LITDAENCKQLMPKLQEAVRNESH--PIEMKMTRVASELSYTIKSYLEETMETMMRTGIE 799
            .:   .|.:|.....::|.|.||..:.||  .::.|:..:..::....:..:::..:|.:.|...
  Rat   775 HQAEDAIQNANFSLSILPILFEAGSSPSHHWQLQQKLEGLLGQVGEICRQDIQDFTQTTLDTTRS 839

  Fly   800 QCPKTLGNQIVVQDLRKALAERLV--------VPEEFLQICL--LNNAGSEIMNKVGE--IEQSL 852
            .||:.|..    ...||.|...||        :||..||..|  |.:....|...:.|  :.|:|
  Rat   840 LCPQMLQR----PGWRKQLEGVLVGSGGLPELLPEHLLQDALTRLRDMRLSITGTLAENIVAQAL 900

  Fly   853 AAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILP 917
            |..  ..|.|.::|:|.:        ::|..::  |..|.:.               |...::|.
  Rat   901 AGL--HAARDRLVESLAQ--------QAPVTVV--PAVPPLC---------------GDELTLLE 938

  Fly   918 KLGLES---PTKLE------------YLNLATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLE 967
            ..|:|.   ||:.|            :|..:...|.......|::....           |:|..
  Rat   939 SGGVEEFFFPTEEEEEREKDDGSSWKWLEPSNCFLVPSLHGAAEEAERD-----------PELAA 992

  Fly   968 SPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHLVKGRPK 1032
            ........:..|||.:...||....|.....:               :||.|...|:|..:.||:
  Rat   993 PGEDAEPQAGPSARGSPSPAAPGPPAGPLPRM---------------DLPPAGQPLRHPTRARPR 1042

  Fly  1033 RAKT---RAP-----TRPLVTTECAGGSREIGEGLEHFF-----------RPGSVTPTT--LTPL 1076
            ..:.   |.|     ..|.:..|..|.:..:.||:|.||           .|...|.|.  .||:
  Rat  1043 PRRQHHHRPPPGGPQVSPALLQEGNGLTARVDEGVEEFFSKRLIQQDRLWAPEEDTATEGGTTPV 1107

  Fly  1077 VSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDN 1141
            .....::..:|.....|..:|   |.....||:|                    ..|.|:|.|
  Rat  1108 PRTLRKKLGTLFAFKKPRSTR---GPRPDLETSP--------------------GAAARARKT-- 1147

  Fly  1142 LEKYSPLVGRKSPLVKMRTEGGPGSGSATGAEE--TSMPSS---NLLKATAREDKTRS----PSS 1197
                  .:|.     .:|....||.|...|..|  ||.|.:   |..:.| ||.|..|    |:.
  Rat  1148 ------TLGD-----LLRPPARPGRGEEPGGAEGGTSSPDAARRNRPRYT-RESKAYSMILLPAE 1200

  Fly  1198 DSIKSHAAGEGSVIVKTGNGIL------RTPIVLQK------------PRPWSVVGSEPKAG--G 1242
            :.....|..:....::.|:..|      |..:|||:            .|..|..|...|||  |
  Rat  1201 EEAAVGARPDKRRPLERGDTELAPSFEQRVQVVLQRIGVSRGSGGAESKRKQSKDGEIKKAGSDG 1265

  Fly  1243 DLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIA------------LSTSGGGS 1295
            |::      |||..||....:.....|:...:|.....|..|..|            |...|.|.
  Rat  1266 DIM------DSSTETPPISIKSRTHSVSADPSCRPGPGGQGPESATWKTLGQQLNAELRGRGWGQ 1324

  Fly  1296 IVGITPGGALEKKSVRELAAGLNRMELPLKPPVMPRTLLNATSVRTSTSSTGSTSNSV 1353
            ..|..|.......|.|..:...:.:.||..|.:.||.  ....:|....|.|..:.||
  Rat  1325 QDGPGPPSPCPSPSPRRTSPAPDILSLPEDPCLGPRN--EDGQLRPRPLSAGRRAVSV 1380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	128/321 (40%)
		leucine-rich repeat	289..331	CDD:275381	9/41 (22%)
		leucine-rich repeat	332..352	CDD:275381	9/19 (47%)
		leucine-rich repeat	364..389	CDD:275380	12/28 (43%)
		leucine-rich repeat	391..417	CDD:275380	13/25 (52%)
		leucine-rich repeat	418..449	CDD:275380	10/30 (33%)
		LRR_RI	441..>656	CDD:238064	87/214 (41%)
		leucine-rich repeat	450..467	CDD:275380	12/16 (75%)
		leucine-rich repeat	468..503	CDD:275380	15/34 (44%)
		leucine-rich repeat	508..534	CDD:275380	9/25 (36%)
		leucine-rich repeat	535..564	CDD:275380	5/28 (18%)
		leucine-rich repeat	570..596	CDD:275380	10/25 (40%)
		leucine-rich repeat	597..618	CDD:275380	13/20 (65%)
		CARMIL_C	797..1108	CDD:292619	70/358 (20%)
Carmil2	XP_038954145.1	Carm_PH	<102..176	CDD:407743	19/86 (22%)
		leucine-rich repeat	278..302	CDD:275381	10/23 (43%)
		leucine-rich repeat	303..332	CDD:275381	13/28 (46%)
		leucine-rich repeat	333..360	CDD:275381	8/33 (24%)
		LRR_RI	335..700	CDD:423007	147/378 (39%)
		leucine-rich repeat	362..393	CDD:275381	11/30 (37%)
		leucine-rich repeat	394..424	CDD:275381	13/29 (45%)
		leucine-rich repeat	425..451	CDD:275381	13/25 (52%)
		leucine-rich repeat	452..483	CDD:275381	10/30 (33%)
		leucine-rich repeat	484..506	CDD:275381	14/21 (67%)
		leucine-rich repeat	508..541	CDD:275380	10/32 (31%)
		leucine-rich repeat	569..595	CDD:275380	3/25 (12%)
		leucine-rich repeat	596..630	CDD:275380	15/33 (45%)
		leucine-rich repeat	631..650	CDD:275380	11/18 (61%)
		CARMIL_C	837..1126	CDD:406410	68/345 (20%)
		PHA03247	<984..1452	CDD:223021	100/468 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52641
OrthoDB	1	1.010	-	-		D208951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103674
Panther	1	1.100	-	-	LDO	PTHR24112
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860