DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and Carmil1

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_017456025.1	Gene:	Carmil1 / 306941	RGDID:	1306623	Length:	1428	Species:	Rattus norvegicus

Alignment Length:	1509	Identity:	517/1509 - (34%)
Similarity:	774/1509 - (51%)	Gaps:	233/1509 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SQLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHY 69
            |.:.::|.||:|.::||..||.||..||||.|||:.||:|||.|..|.:||||::|||:|..|.|
  Rat     6 SDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPTKLELTFSY 70

  Fly    70 LDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTV-P 133
            |:|.||...|.|...:.|           :..|. |::...|.:|..:|..:.:.:::|||.: |
  Rat    71 LEIHGVICHKPTQMVVET-----------EKCNV-SMKMASLEDASDVLAHIGTCLRRIFPGLSP 123

  Fly   134 LKYIIRKIDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAWDVDTIYL 198
            |: |::|:.::|.||.......:........|||||||..|||:||:.|..|||||.||||||||
  Rat   124 LR-IMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYREEVQWDVDTIYL 187

  Fly   199 SHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMWLEELH 263
            :.|||.|||:||.|||.:||:.|::|||||.:|..|.:..::||.:..|:||.|:.||..||||.
  Rat   188 TQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNLLEELV 252

  Fly   264 LEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKV 328
            ||..|||.||..||:.::..|.|..:.||:|:.|.:||:|.|||...|              ||:
  Rat   253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQF--------------AKL 303

  Fly   329 SKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLK-DDITNLHNFLAQPNVLE 392
            .|||..|.|:...|:.||||.:..||:.|...:::||:||||||.|: ||:::::|||||||.:.
  Rat   304 PKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNVLRGDDLSHMYNFLAQPNTIV 368

  Fly   393 HLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAG 457
            ||||::|:.:||.:..||||||...||.||:|.:.||.:||||:||||||||:|:.:|..:|::|
  Rat   369 HLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSG 433

  Fly   458 CKLPMEALKNLLLGLACNESTAGLYLDLSSNTLG----AQGAHVLESCIHGVRVLQSLDISDNNL 518
            .||..|.||.||||||||.|..|:.||||:..||    :.||.|||.||..:..:.|||||||.|
  Rat   434 TKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGL 498

  Fly   519 DAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENKLKHD 583
            :::|:.::..:|:|.||:.|.|.::...||.|::.||:|.||.:||.:|.||..|.|:::|||.:
  Rat   499 ESDLSTLIVWLSRNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKTE 563

  Fly   584 LHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIVYALE 648
            :...|||||||.||.|:|||||.|||:||::||||||||.:|||:..|||.:|.||:.||..|:|
  Rat   564 VTIIINALGSNTSLTKVDISGNSMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAME 628

  Fly   649 HNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGFMLSSTHQ 713
            .|:::|.:|.|::|.:..||:.|:||:..::|::..|.||....|....|.:|||.|.:.|:|.|
  Rat   629 KNYTLRFMPIPMYDASQALKTSPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQ 693

  Fly   714 LVDKLVAETQDTIS--LAKGG---SESASAVQRLITDAENCKQLMPKLQE--------AVRNESH 765
            ::|::..:.||.::  .|.||   .|...|.:||:.||:|.|.|:|.|..        |....|.
  Rat   694 MIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSS 758

  Fly   766 PIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQ 830
            ||:..:..:|.|::..:...|:..:|:|:......||..:....:.|||..|..|::.:|..|::
  Rat   759 PIQEILESMAGEVTRVVDEQLKGLLESMVDAAENLCPNVMRKAHIRQDLIHASTEKISIPRTFVK 823

  Fly   831 ICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMG-----IAESPSVLLDEPQT 890
            ..||..:|.:|:||:.|::.::|:.:|||..||:|::|:...|.:.     :::|      .||.
  Rat   824 NVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSNSHRKLANHFSRLSKS------LPQR 882

  Fly   891 PDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLA--------TPHLPTKRRSL-AK 946
            .|:       :.:.:..:|..| :||....|....|||.|:..        ||  .:||:|: ::
  Rat   883 EDL-------EVELVEEKPVKR-AILTVEDLTEVEKLEDLDTCMTLCCTSMTP--KSKRKSIHSR 937

  Fly   947 KVRPQSVVENL------SLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGG 1005
            .:||.|....:      :|...|..:|.|...      |.|....::.|
  Rat   938 MLRPVSRAFEMEFDLDKALEEVPIHIEDPPFP------SVRQEKRSSGL---------------- 980

  Fly  1006 VDECCDSITELPS-ASFQLQHLVKGRPKRAKTRAPTRPLVTT--------ECAGGSREIGEGLEH 1061
                   |:|||| ...:|:|..|.||||.|.:.||:..|.:        |..|....:.||::.
  Rat   981 -------ISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCSINIIPHDGEQNGLMGRVDEGVDE 1038

  Fly  1062 FFRPGSVTPTTLTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPL 1126
            ||          |..|  |..:|..     |.|...|.:..:..:|     :::|..:......|
  Rat  1039 FF----------TKKV--TKMDCKR-----SSTRCSDTHDLVEGDE-----KKKRDSRRSGFLNL 1081

  Fly  1127 LKSASWATRSRS--------TDNLEKYSPLVGRKSPLV---KMRTEGGPGSGSATGAEETSMPSS 1180
            :||     ||||        |:.|.  ||....:||.|   :...:....:|:....||...|..
  Rat  1082 IKS-----RSRSERPPTVLMTEELS--SPKGAVRSPPVDTARKEIKAAEHNGAPERTEEMRTPEP 1139

  Fly  1181 NLLKATAREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRPWSVVGSEPKAGGDLI 1245
              |:....|:..|:..|||..|...|...|.| .|:|:|......|:.|   ...::.|.|.|:|
  Rat  1140 --LEEGLAEEAGRAERSDSRGSPQGGRRYVQV-MGSGLLAEMKAKQERR---AACAQKKLGNDVI 1198

  Fly  1246 TGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSGGGSIVGITPG-------- 1302
                :.|.|.......|..|                          ||.::..:.||
  Rat  1199 ----SQDPSSPVMSNTERLD--------------------------GGATVPKLQPGLPEARFGL 1233

  Fly  1303 GALEKKSVRE--LAAGL---NRMELPLKP-----------------PVMPRTLLNATSVRTSTSS 1345
            |..||.:..|  :..|.   |...:|..|                 |..|||......  |..|.
  Rat  1234 GTPEKNAKAEPRVDGGCRSRNSSSMPTSPKPLLQSPKPSPAARPSIPQKPRTASKPED--TPDSP 1296

  Fly  1346 TGSTSNSVSVSSSTNANTSMTVLNQSQTRSRIVSSTSSTDSTETIT--ERSTTSTSSSSSSSYEK 1408
            :|.:|..|::........|:......|:.|:   |:..|.|.|.:.  :.....:.....||..|
  Rat  1297 SGPSSPKVALLPPILKKVSLDKERDDQSSSQ---SSPRTFSQEVVQRGDHFKRHSDHDKPSSRGK 1358

  Fly  1409 QHAKACANLISNEI 1422
            :.:|.|..:...|:
  Rat  1359 RSSKLCFAIAEEEV 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	158/322 (49%)
		leucine-rich repeat	289..331	CDD:275381	13/41 (32%)
		leucine-rich repeat	332..352	CDD:275381	8/19 (42%)
		leucine-rich repeat	364..389	CDD:275380	16/25 (64%)
		leucine-rich repeat	391..417	CDD:275380	13/25 (52%)
		leucine-rich repeat	418..449	CDD:275380	20/30 (67%)
		LRR_RI	441..>656	CDD:238064	112/218 (51%)
		leucine-rich repeat	450..467	CDD:275380	7/16 (44%)
		leucine-rich repeat	468..503	CDD:275380	22/38 (58%)
		leucine-rich repeat	508..534	CDD:275380	11/25 (44%)
		leucine-rich repeat	535..564	CDD:275380	11/28 (39%)
		leucine-rich repeat	570..596	CDD:275380	13/25 (52%)
		leucine-rich repeat	597..618	CDD:275380	14/20 (70%)
		CARMIL_C	797..1108	CDD:292619	82/339 (24%)
Carmil1	XP_017456025.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336031
Domainoid	1	1.000	205	1.000	Domainoid score	I2836
eggNOG	1	0.900	-	-		E1_KOG4242
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9757
Inparanoid	1	1.050	700	1.000	Inparanoid score	I642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208951at2759
OrthoFinder	1	1.000	-	-		FOG0002311
OrthoInspector	1	1.000	-	-		otm44751
orthoMCL	1	0.900	-	-		OOG6_103674
Panther	1	1.100	-	-	O	PTHR24112
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2004
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800