DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and Carmil3

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006519110.1	Gene:	Carmil3 / 268747	MGIID:	2448573	Length:	1386	Species:	Mus musculus

Alignment Length:	1462	Identity:	442/1462 - (30%)
Similarity:	675/1462 - (46%)	Gaps:	286/1462 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QLTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYL 70
            :||::|.:|::..|.:.. :|.::.||||||..|.|:|||..|..|::|...|||.|:|..|:.|
Mouse     7 ELTRELQDSIRRCLSQGA-VLQQHRVKLETKPKKFEDRVLALTSWRLHLFPLKVPAKVESSFNVL 70

  Fly    71 DI----------VGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAI 125
            :|          :.||:::.|                      .|:|.....:.|.:...::||:
Mouse    71 EIRAFNTLSQNQILVETERGT----------------------VSMRLPSAESVDQVTRHVSSAL 113

  Fly   126 KQIFPTVPLKYIIRKIDIQPPE--RETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREE 188
            .::.|....  :||:.:...||  |:|..:.|...|...:|  |||||..||.:||::|:..|||
Mouse   114 SKVCPGPGC--LIRRGNADTPEGPRDTSPNSETSTSTTHSV--CGGFSETYAALCDYNGLHCREE 174

  Fly   189 VAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVL 253
            |.|||||||.:.|.|..||.||.|||.:||..:|:||.||.:|..|....:||..|.||::||.|
Mouse   175 VQWDVDTIYHAEDNREFNLLDFSHLESRDLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLHTL 239

  Fly   254 KRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGA 318
            .:|..||||.|:..||:.||:.||:.....|.:..:..:.||||.|||||..||....
Mouse   240 SKSGSLEELVLDNAGLKTDFVQKLAGVFGENGSCVLHALILSHNPIEDKGFLSLSQQL------- 297

  Fly   319 IHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNS---LKDDITN 380
              |..|     .||.||.||...::.:|:..:..:...|.:.::||.|||||.|.   ..|:...
Mouse   298 --LCFP-----TGLTKLCLAKTAISPRGLQALGQTFGANPAFASSLRYLDLSKNPGLLATDEANA 355

  Fly   381 LHNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFT 445
            |::||||||.|.||||:.||..::.|.||||.||.:||.:||::.||.|.:||:|.||:|||||:
Mouse   356 LYSFLAQPNALVHLDLSGTDCAVDMLLGALLHGCCSHLTYLNLARNSCSHRKGREAPPAFKQFFS 420

  Fly   446 STFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQS 510
            |.::|.|:|::..:||:|||:.||.||:.|...:.|:|||||..|.:.||..|:..:..|..:.|
Mouse   421 SVYTLSHVNLSATRLPLEALRALLQGLSLNSHLSDLHLDLSSCELRSAGAQALQEQLGAVTCIGS 485

  Fly   511 LDISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVL 575
            ||:|||..|::|..::.|:.||.|::.|.|.::. .:|.|.:..::..||.|||::|..|..|.:
Mouse   486 LDLSDNGFDSDLLTLVPALGKNKSLKHLFLGKNF-NVKAKTLEEILHKLVQLIQEEDCSLQSLSV 549

  Fly   576 SENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGY 640
            ::::||......|||||||..|.|:|:|||.|.|:||::|:||||||:.||||..|:|..:..|:
Mouse   550 ADSRLKLRTSILINALGSNTCLAKVDLSGNGMEDIGAKMLSKALQINSSLRTILWDRNNTSALGF 614

  Fly   641 ADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHG 705
            .||..|||.||::|.:.|||.||:...:|.|::|:.|.:|:|..|.||.:.......|.||||.|
Mouse   615 LDIARALESNHTLRFMSFPVSDISQAYRSAPERTEDVWQKIQWCLVRNNHSQTCPQEQAFRLQQG 679

  Fly   706 FMLSSTHQLVDKLVAETQDTISLAK-----GGSESASAVQRLITDAENCKQLMPKLQE---AVRN 762
            .:.||..|::.:|....|:.:...:     ...:.....:.||.||:|.:.|.|.|.|   .:.|
Mouse   680 LVTSSAEQMLQRLCGRVQEEVRALRLCPLEPVQDELLYARDLIKDAKNSRALFPSLYELGHVLAN 744

  Fly   763 ESHPIEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCP----------KTLGNQIVVQDLRKA 817
            :. |:..::..||||:|..:...|:..:|:|:....|.||          |.|.|
Mouse   745 DG-PVRQRLESVASEVSKAVDKELQVILESMVSLTQELCPVAMRVAEGHNKMLSN---------- 798

  Fly   818 LAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLE-------ALTRYRRGM 875
            :|||:.||..|::..||..||.:|.||:.|::.|:...:::...||:|:       :|.|:...:
Mouse   799 VAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTNSIVDEILQELYHSHKSLARHLTQL 863

  Fly   876 GIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTK 940
            .....|.....:.|.|.......:||.:                  |:..:|. .|:.|  :..|
Mouse   864 RTLSDPPGGASQGQDPSSRGRGRNHDHE------------------ETDDELG-TNIDT--MAIK 907

  Fly   941 RRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQL-SARAAAGAAALVGAANMTDSIAVDDG 1004
            ::...:|:||.|.            ..|.|.....||| |.....|..:.:||:..|.|
Mouse   908 KQKRCRKIRPVSA------------FISGSPQDMESQLGSLGIPPGWFSGLGASQTTAS------ 954

  Fly  1005 GVDECCDSITELPSASFQLQHLVKGRPKRAKTR--APTRPLVTTECAGGSREIG------EGLEH 1061
               ...:.::|||:..::|:|..:|||:..:|.  .|.|| ......|..:|.|      ||||.
Mouse   955 ---GSWEGLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRP-SQVPVPGPRQENGMATRLDEGLED 1015

  Fly  1062 FFR---------------------------------------------------PGSVTPTTLTP 1075
            ||.                                                   |||.|...|.|
Mouse  1016 FFSRRVMDESSSYPRTLRTMRPGLSEPPLPPLQKKRRRGLFHFRRPRSFKGDRGPGSPTAGLLLP 1080

  Fly  1076 LVSPTSEECSSLSFVDSPTMSRDGNGHMTSEETTPILE----------------------ERRPI 1118
            ...|......|....|.|::..:.:...:.||.:.:|.                      |..|.
Mouse  1081 PPPPPPPTQESPPSPDPPSLGNNSSPCWSPEEESSLLPGFGGARGSSFCRKMGTERLEAGEGAPA 1145

  Fly  1119 KLERQSP----------LLKSASWA--TRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSATG 1171
            ....|.|          |.::..|:  .:...||..::.|....:|.   :...:.|||:.....
Mouse  1146 PGTAQQPRVHGGVALPGLGRTKGWSFDGKREGTDPDQEDSTQAWQKR---RSSDDAGPGAWKPPP 1207

  Fly  1172 AEETSMPSSNLLK---AT---AREDKTRSPSSDSIKSHAAGEGSVIVKTGNGILRTPIVLQKPRP 1230
            ..::|.||.:.::   ||   |......||:.:|..:|:.                    |.|.|
Mouse  1208 PPQSSKPSFSAMRRAEATWHIASPPVCYSPAEESAANHSC--------------------QSPSP 1252

  Fly  1231 WSVVGSEPKAGG---DLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIVGITPGIALSTSG 1292
            .|..|.|.|.|.   :.:....||        ||:|..              :|..|...::...
Mouse  1253 ASQDGDEEKQGALFPERMVPTRNA--------KLQEPP--------------IGPRPPKPVAVPR 1295

  Fly  1293 GGSIVGITPGGALEKKSVRELAAGLNRMELPL 1324
            |.....: |||..|.:| ...|.|.|:..|.|
Mouse  1296 GRRAPQV-PGGREETES-SSAAPGANKPRLRL 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	136/320 (43%)
		leucine-rich repeat	289..331	CDD:275381	13/41 (32%)
		leucine-rich repeat	332..352	CDD:275381	6/19 (32%)
		leucine-rich repeat	364..389	CDD:275380	13/27 (48%)
		leucine-rich repeat	391..417	CDD:275380	14/25 (56%)
		leucine-rich repeat	418..449	CDD:275380	17/30 (57%)
		LRR_RI	441..>656	CDD:238064	94/214 (44%)
		leucine-rich repeat	450..467	CDD:275380	8/16 (50%)
		leucine-rich repeat	468..503	CDD:275380	15/34 (44%)
		leucine-rich repeat	508..534	CDD:275380	11/25 (44%)
		leucine-rich repeat	535..564	CDD:275380	7/28 (25%)
		leucine-rich repeat	570..596	CDD:275380	11/25 (44%)
		leucine-rich repeat	597..618	CDD:275380	11/20 (55%)
		CARMIL_C	797..1108	CDD:292619	83/387 (21%)
Carmil3	XP_006519110.1	Carm_PH	30..118	CDD:375405	30/109 (28%)
		leucine-rich repeat	245..273	CDD:275381	12/27 (44%)
		leucine-rich repeat	275..303	CDD:275380	13/41 (32%)
		leucine-rich repeat	304..335	CDD:275380	7/30 (23%)
		LRR_RI	307..600	CDD:393385	127/293 (43%)
		leucine-rich repeat	336..365	CDD:275380	14/28 (50%)
		leucine-rich repeat	366..391	CDD:275380	14/24 (58%)
		leucine-rich repeat	393..420	CDD:275380	15/26 (58%)
		leucine-rich repeat	425..455	CDD:275380	13/29 (45%)
		leucine-rich repeat	456..479	CDD:275380	10/22 (45%)
		LRR_RI	475..>640	CDD:393385	71/165 (43%)
		leucine-rich repeat	480..509	CDD:275380	12/28 (43%)
		leucine-rich repeat	544..570	CDD:275380	11/25 (44%)
		leucine-rich repeat	571..598	CDD:275380	17/26 (65%)
		CARMIL_C	778..1062	CDD:374283	72/336 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832381
Domainoid	1	1.000	127	1.000	Domainoid score	I5360
eggNOG	1	0.900	-	-		E1_KOG4242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	702	1.000	Inparanoid score	I662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208951at2759
OrthoFinder	1	1.000	-	-		FOG0002311
OrthoInspector	1	1.000	-	-		otm42686
orthoMCL	1	0.900	-	-		OOG6_103674
Panther	1	1.100	-	-	O	PTHR24112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3852
SonicParanoid	1	1.000	-	-		X2004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790