DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRR and Carmil2

DIOPT Version :9

Sequence 1:NP_001260788.1 Gene:LRR / 35715 FlyBaseID:FBgn0033212 Length:1486 Species:Drosophila melanogaster
Sequence 2:XP_017168231.1 Gene:Carmil2 / 234695 MGIID:2685431 Length:1409 Species:Mus musculus


Alignment Length:1456 Identity:406/1456 - (27%)
Similarity:619/1456 - (42%) Gaps:258/1456 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 ESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGV-- 75
            |..:.:..:..::|:|..:..|   ...::.:|.....|.|||...:|.:::|.|.||::..:  
Mouse    15 EITRFLWPKEAELLLKTWLPQE---GAEQSHILALLRWRAYLLHTCLPLRVDCTFSYLEVQAMAL 76

  Fly    76 -ESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLKYIIR 139
             |:.....|.:  ...|...:      .|..|     ...:.:...:|:|||::||...|..:.|
Mouse    77 QETPPRVTFEL--ESLPELVL------EFPCV-----AALEQLAQHVAAAIKKVFPRSTLGKLFR 128

  Fly   140 K---------IDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAW--DV 193
            |         ::...|...||      ||     .|||||...|..:||::|.|:|||:.|  ||
Mouse   129 KPTPSSLLARLERSHPLESTI------PS-----SPCGGFLETYEALCDYNGFPFREEIQWVRDV 182

  Fly   194 DTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMW 258
            ||||.....|...|.||.|...:||...|:||.||.:||.|....|:||.|..|:|||:..:|.:
Mouse   183 DTIYHRQGCRHFCLGDFSHFGSRDLALSVAALSYNLWFRRLSCEDMKLSLEVSEQILHMTSQSSY 247

  Fly   259 LEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAG 323
            ||||.|||.|||.||:.:|:.::..:.|..:|.:.||.|:::|:|.::|.       :...|..|
Mouse   248 LEELVLEACGLRGDFVRRLAQALAGHFNSGLRELSLSGNLLDDRGMAALS-------RHLEHCPG 305

  Fly   324 PIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGN----SLKDDITNLHNF 384
                   .|.:|:||..|||.:|:..:..:|..|.:..::||:||||||    ....|...|:.|
Mouse   306 -------ALRRLSLAQTGLTPRGMRALGRALATNATFDSTLTHLDLSGNPGALGPSQDSGGLYTF 363

  Fly   385 LAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFS 449
            |::||||.:|:||.||.||..||.||..||.:.|.||..|.|.||..|.:..|.:.::|...|..
Mouse   364 LSRPNVLAYLNLAGTDATLGTLFTALAGGCCSSLTHLEASRNIFSRMKSQAAPAALQRFLGGTRM 428

  Fly   450 LKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDIS 514
            |:||.:||||||.|||:.||.|||.|.....|:||||:..|.:.||.|::..:.....|.|||:|
Mouse   429 LRHLGLAGCKLPPEALRALLEGLALNTQIHDLHLDLSACELRSVGAQVIQDLVCDAGALSSLDLS 493

  Fly   515 DNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENK 579
            ||...:::..::.||.::.|::.:.|.|:......:.:..|:..:..|:|.||.||..|.::|::
Mouse   494 DNGFGSDMVTLVLAIGRSRSLKHVALGRNFNVRCKETLDDVLHRIAQLMQDDDCPLQSLSVAESR 558

  Fly   580 LKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIV 644
            ||......|.|||:|..|..||||||.:||.||::|||||::|.|||::..|:|..:..|..|:.
Mouse   559 LKQGASILIRALGTNPKLTALDISGNAIGDAGAKMLAKALRVNTRLRSVIWDRNNTSALGLLDVA 623

  Fly   645 YALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQH-GFML 708
            .|||.|||::::|.|:.|:....:|.|:.|...:.::|..|.|| |.:...:.....||. |.:.
Mouse   624 QALEQNHSLKSMPLPLNDVTQAHRSRPELTTRAVHQIQACLWRN-NQVDSTSDLKPCLQPLGLIS 687

  Fly   709 SSTHQLVDKLVAETQDTISL--AKGGSESASAVQR---LITDAENCKQLMPKLQEAVRNESH--P 766
            ..:.|.|::|....|:.:.|  ...|.:...||.:   .|.:|.....::|.|.||.|:.||  .
Mouse   688 DHSEQEVNELCQSVQEHMELLGCGAGPQGEVAVHQAEDAIQNANFSLSILPILYEAGRSPSHHWQ 752

  Fly   767 IEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLV----VPEE 827
            ::.|:..:..::....:..:::..:|.:.|....||:.|    .....||.|...||    :| |
Mouse   753 LQQKLESLLGQVGEICRQDIQDFTQTTLDTTRSLCPQML----QTPGWRKQLEGVLVGSGGLP-E 812

  Fly   828 FLQICLLNNAGSEI----MNKVGEIEQSLAA---AISDRATDEVLEALTRYRRGMGIAESPSVLL 885
            .|...||.:|.|.:    ::..|.:.:|:.|   |....|.|.::|.||:               
Mouse   813 LLPEHLLQDAFSRLRDMRLSITGTLAESIVAQALAGLHAARDRLVERLTQ--------------- 862

  Fly   886 DEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTKRRSLAKK--- 947
               |.|             :.:.|.     :|.||....:.||...|.....||::....:|   
Mouse   863 ---QAP-------------VTMAPA-----VPPLGGNELSPLETGGLEELFFPTEKEEEREKDES 906

  Fly   948 -----VRPQSVVENLSLGH--------FPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSI 999
                 :.|.:....:|..|        .|:|..........:..|||.:...||....|.....:
Mouse   907 SSWKWLEPSNCFHLVSSLHGAAEEAERDPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRM 971

  Fly  1000 AVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKT---RAP-----TRPLVTTECAGGSREIG 1056
                           :||.|...|:|..:.||:..:.   |.|     ..|.:..|..|.:..:.
Mouse   972 ---------------DLPPAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALLQEGNGLTARVD 1021

  Fly  1057 EGLEHFFRPGSV----------TPTT---LTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEET 1108
            ||:|.||....:          .|.|   .||:.....::..:|.....|..:|   |.....||
Mouse  1022 EGVEEFFSKRLIQQDHFWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTR---GPRPDLET 1083

  Fly  1109 TPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVK-MRTEGGPGSGSATGA 1172
            :|....|                                  .|||.|.. :|....||.|...|.
Mouse  1084 SPGAAAR----------------------------------ARKSTLGDLLRPPARPGRGEEPGG 1114

  Fly  1173 EE--TSMP-----------------SSNLLKAT------AREDKTRSPSSDSIKSHAAGEGSVIV 1212
            .|  ||.|                 |..||.|.      .|.||.|.......:...:.|..|.|
Mouse  1115 AEGGTSSPDPARRNRPRYTRESKAYSMILLPAEEEAAVGTRPDKRRPLERGDTELAPSFEQRVQV 1179

  Fly  1213 KTGN-GILRTPIVLQKPRPWSVVGSEPKAG--GDLITGNGNADSSKTTPDKLEEDDVEIVTFGNT 1274
            .... |:.|.....:..|..|..|...|||  ||::      |||..||....:.....|:...:
Mouse  1180 MLQRIGVSRASGGAESKRKQSKDGEIKKAGSDGDIM------DSSTETPPISIKSRTHSVSADPS 1238

  Fly  1275 CSGSIVGITPGIA------------LSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPP 1327
            |.....|..|..|            |...|.|...|..|.......|.|..:...:.:.||..|.
Mouse  1239 CRPGPGGQGPESATWKTLGQQLNAELRGRGWGQQDGPGPPSPCPSPSPRRTSPAPDILSLPEDPC 1303

  Fly  1328 VMPRTLLNATSVRTSTSSTGSTSNSV 1353
            :.||.  ....:|....|.|..:.||
Mouse  1304 LGPRN--EDGQLRPRPLSAGRRAVSV 1327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRNP_001260788.1 LRR_RI 198..516 CDD:238064 129/321 (40%)
leucine-rich repeat 289..331 CDD:275381 9/41 (22%)
leucine-rich repeat 332..352 CDD:275381 8/19 (42%)
leucine-rich repeat 364..389 CDD:275380 12/28 (43%)
leucine-rich repeat 391..417 CDD:275380 14/25 (56%)
leucine-rich repeat 418..449 CDD:275380 11/30 (37%)
LRR_RI 441..>656 CDD:238064 87/214 (41%)
leucine-rich repeat 450..467 CDD:275380 12/16 (75%)
leucine-rich repeat 468..503 CDD:275380 15/34 (44%)
leucine-rich repeat 508..534 CDD:275380 9/25 (36%)
leucine-rich repeat 535..564 CDD:275380 4/28 (14%)
leucine-rich repeat 570..596 CDD:275380 10/25 (40%)
leucine-rich repeat 597..618 CDD:275380 13/20 (65%)
CARMIL_C 797..1108 CDD:292619 72/358 (20%)
Carmil2XP_017168231.1 Carm_PH 41..119 CDD:375405 19/90 (21%)
leucine-rich repeat 223..247 CDD:275381 10/23 (43%)
leucine-rich repeat 248..277 CDD:275381 14/28 (50%)
leucine-rich repeat 278..305 CDD:275381 8/33 (24%)
LRR_RI 280..645 CDD:393385 146/378 (39%)
leucine-rich repeat 307..338 CDD:275381 10/30 (33%)
leucine-rich repeat 339..369 CDD:275381 13/29 (45%)
leucine-rich repeat 370..396 CDD:275381 14/25 (56%)
leucine-rich repeat 397..428 CDD:275381 11/30 (37%)
leucine-rich repeat 429..451 CDD:275381 14/21 (67%)
leucine-rich repeat 461..486 CDD:275380 8/24 (33%)
leucine-rich repeat 514..547 CDD:275380 6/32 (19%)
leucine-rich repeat 549..575 CDD:275380 10/25 (40%)
leucine-rich repeat 576..596 CDD:275380 12/19 (63%)
CARMIL_C 783..1072 CDD:374283 69/344 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832380
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52641
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103674
Panther 1 1.100 - - LDO PTHR24112
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3852
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.880

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