Protein Alignment LRR and Carmil2

DIOPT Version :10

• Sequence 1: NP_001260788.1
• Gene: LRR / 35715
• FlyBaseID: FBgn0033212
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: XP_017168231.1
• Gene: Carmil2 / 234695
• MGIID: 2685431
• Length: 1409
• Species: Mus musculus
• Alignment Length: 1456
• Identity: 406/1456 - (27%)
• Similarity: 619/1456 - (42%)
• Gaps: 258/1456 - (17%)

  Fly    13 ESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLDIVGV-- 75
            |..:.:..:..::|:|..:..|   ...::.:|.....|.|||...:|.:::|.|.||::..:
Mouse    15 EITRFLWPKEAELLLKTWLPQE---GAEQSHILALLRWRAYLLHTCLPLRVDCTFSYLEVQAMAL 76

  Fly    76 -ESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLKYIIR 139
             |:.....|.:  ...|...:      .|..|     ...:.:...:|:|||::||...|..:.|
Mouse    77 QETPPRVTFEL--ESLPELVL------EFPCV-----AALEQLAQHVAAAIKKVFPRSTLGKLFR 128

  Fly   140 K---------IDIQPPERETIFSEEFRPSDPRNVGPCGGFSAQYACMCDFHGVPYREEVAW--DV 193
            |         ::...|...||      ||     .|||||...|..:||::|.|:|||:.|  ||
Mouse   129 KPTPSSLLARLERSHPLESTI------PS-----SPCGGFLETYEALCDYNGFPFREEIQWVRDV 182

  Fly   194 DTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLKRSMW 258
            ||||.....|...|.||.|...:||...|:||.||.:||.|....|:||.|..|:|||:..:|.:
Mouse   183 DTIYHRQGCRHFCLGDFSHFGSRDLALSVAALSYNLWFRRLSCEDMKLSLEVSEQILHMTSQSSY 247

  Fly   259 LEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAG 323
            ||||.|||.|||.||:.:|:.::..:.|..:|.:.||.|:::|:|.::|.       :...|..|
Mouse   248 LEELVLEACGLRGDFVRRLAQALAGHFNSGLRELSLSGNLLDDRGMAALS-------RHLEHCPG 305

  Fly   324 PIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGN----SLKDDITNLHNF 384
                   .|.:|:||..|||.:|:..:..:|..|.:..::||:||||||    ....|...|:.|
Mouse   306 -------ALRRLSLAQTGLTPRGMRALGRALATNATFDSTLTHLDLSGNPGALGPSQDSGGLYTF 363

  Fly   385 LAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFS 449
            |::||||.:|:||.||.||..||.||..||.:.|.||..|.|.||..|.:..|.:.::|...|..
Mouse   364 LSRPNVLAYLNLAGTDATLGTLFTALAGGCCSSLTHLEASRNIFSRMKSQAAPAALQRFLGGTRM 428

  Fly   450 LKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSLDIS 514
            |:||.:||||||.|||:.||.|||.|.....|:||||:..|.:.||.|::..:.....|.|||:|
Mouse   429 LRHLGLAGCKLPPEALRALLEGLALNTQIHDLHLDLSACELRSVGAQVIQDLVCDAGALSSLDLS 493

  Fly   515 DNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLSENK 579
            ||...:::..::.||.::.|::.:.|.|:......:.:..|:..:..|:|.||.||..|.::|::
Mouse   494 DNGFGSDMVTLVLAIGRSRSLKHVALGRNFNVRCKETLDDVLHRIAQLMQDDDCPLQSLSVAESR 558

  Fly   580 LKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYADIV 644
            ||......|.|||:|..|..||||||.:||.||::|||||::|.|||::..|:|..:..|..|:.
Mouse   559 LKQGASILIRALGTNPKLTALDISGNAIGDAGAKMLAKALRVNTRLRSVIWDRNNTSALGLLDVA 623

  Fly   645 YALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQH-GFML 708
            .|||.|||::::|.|:.|:....:|.|:.|...:.::|..|.|| |.:...:.....||. |.:.
Mouse   624 QALEQNHSLKSMPLPLNDVTQAHRSRPELTTRAVHQIQACLWRN-NQVDSTSDLKPCLQPLGLIS 687

  Fly   709 SSTHQLVDKLVAETQDTISL--AKGGSESASAVQR---LITDAENCKQLMPKLQEAVRNESH--P 766
            ..:.|.|::|....|:.:.|  ...|.:...||.:   .|.:|.....::|.|.||.|:.||  .
Mouse   688 DHSEQEVNELCQSVQEHMELLGCGAGPQGEVAVHQAEDAIQNANFSLSILPILYEAGRSPSHHWQ 752

  Fly   767 IEMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLV----VPEE 827
            ::.|:..:..::....:..:::..:|.:.|....||:.|    .....||.|...||    :| |
Mouse   753 LQQKLESLLGQVGEICRQDIQDFTQTTLDTTRSLCPQML----QTPGWRKQLEGVLVGSGGLP-E 812

  Fly   828 FLQICLLNNAGSEI----MNKVGEIEQSLAA---AISDRATDEVLEALTRYRRGMGIAESPSVLL 885
            .|...||.:|.|.:    ::..|.:.:|:.|   |....|.|.::|.||:
Mouse   813 LLPEHLLQDAFSRLRDMRLSITGTLAESIVAQALAGLHAARDRLVERLTQ--------------- 862

  Fly   886 DEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTKRRSLAKK--- 947
               |.|             :.:.|.     :|.||....:.||...|.....||::....:|
Mouse   863 ---QAP-------------VTMAPA-----VPPLGGNELSPLETGGLEELFFPTEKEEEREKDES 906

  Fly   948 -----VRPQSVVENLSLGH--------FPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSI 999
                 :.|.:....:|..|        .|:|..........:..|||.:...||....|.....:
Mouse   907 SSWKWLEPSNCFHLVSSLHGAAEEAERDPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRM 971

  Fly  1000 AVDDGGVDECCDSITELPSASFQLQHLVKGRPKRAKT---RAP-----TRPLVTTECAGGSREIG 1056
                           :||.|...|:|..:.||:..:.   |.|     ..|.:..|..|.:..:.
Mouse   972 ---------------DLPPAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALLQEGNGLTARVD 1021

  Fly  1057 EGLEHFFRPGSV----------TPTT---LTPLVSPTSEECSSLSFVDSPTMSRDGNGHMTSEET 1108
            ||:|.||....:          .|.|   .||:.....::..:|.....|..:|   |.....||
Mouse  1022 EGVEEFFSKRLIQQDHFWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTR---GPRPDLET 1083

  Fly  1109 TPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVK-MRTEGGPGSGSATGA 1172
            :|....|                                  .|||.|.. :|....||.|...|.
Mouse  1084 SPGAAAR----------------------------------ARKSTLGDLLRPPARPGRGEEPGG 1114

  Fly  1173 EE--TSMP-----------------SSNLLKAT------AREDKTRSPSSDSIKSHAAGEGSVIV 1212
            .|  ||.|                 |..||.|.      .|.||.|.......:...:.|..|.|
Mouse  1115 AEGGTSSPDPARRNRPRYTRESKAYSMILLPAEEEAAVGTRPDKRRPLERGDTELAPSFEQRVQV 1179

  Fly  1213 KTGN-GILRTPIVLQKPRPWSVVGSEPKAG--GDLITGNGNADSSKTTPDKLEEDDVEIVTFGNT 1274
            .... |:.|.....:..|..|..|...|||  ||::      |||..||....:.....|:...:
Mouse  1180 MLQRIGVSRASGGAESKRKQSKDGEIKKAGSDGDIM------DSSTETPPISIKSRTHSVSADPS 1238

  Fly  1275 CSGSIVGITPGIA------------LSTSGGGSIVGITPGGALEKKSVRELAAGLNRMELPLKPP 1327
            |.....|..|..|            |...|.|...|..|.......|.|..:...:.:.||..|.
Mouse  1239 CRPGPGGQGPESATWKTLGQQLNAELRGRGWGQQDGPGPPSPCPSPSPRRTSPAPDILSLPEDPC 1303

  Fly  1328 VMPRTLLNATSVRTSTSSTGSTSNSV 1353
            :.||.  ....:|....|.|..:.||
Mouse  1304 LGPRN--EDGQLRPRPLSAGRRAVSV 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	Carm_PH	25..130	CDD:436119	22/107 (21%)
		RNA1	<198..402	CDD:444072	78/207 (38%)
		leucine-rich repeat	289..331	CDD:275381	9/41 (22%)
		leucine-rich repeat	332..352	CDD:275381	8/19 (42%)
		RNA1	<335..653	CDD:444072	133/321 (41%)
		leucine-rich repeat	364..389	CDD:275380	12/28 (43%)
		leucine-rich repeat	391..417	CDD:275380	14/25 (56%)
		leucine-rich repeat	418..449	CDD:275380	11/30 (37%)
		leucine-rich repeat	450..467	CDD:275380	12/16 (75%)
		leucine-rich repeat	468..503	CDD:275380	15/34 (44%)
		leucine-rich repeat	508..534	CDD:275380	9/25 (36%)
		leucine-rich repeat	535..564	CDD:275380	4/28 (14%)
		leucine-rich repeat	570..596	CDD:275380	10/25 (40%)
		leucine-rich repeat	597..618	CDD:275380	13/20 (65%)
		CARMIL_C	797..1111	CDD:464966	74/361 (20%)
Carmil2	XP_017168231.1	Carm_PH	<43..119	CDD:436119	19/88 (22%)
		PPP1R42	<221..347	CDD:455733	50/139 (36%)
		leucine-rich repeat	223..247	CDD:275381	10/23 (43%)
		leucine-rich repeat	248..277	CDD:275381	14/28 (50%)
		leucine-rich repeat	278..305	CDD:275381	8/33 (24%)
		RNA1	<299..651	CDD:444072	141/358 (39%)
		leucine-rich repeat	307..338	CDD:275381	10/30 (33%)
		leucine-rich repeat	339..369	CDD:275381	13/29 (45%)
		leucine-rich repeat	370..396	CDD:275381	14/25 (56%)
		leucine-rich repeat	397..428	CDD:275381	11/30 (37%)
		leucine-rich repeat	429..451	CDD:275381	14/21 (67%)
		leucine-rich repeat	461..486	CDD:275380	8/24 (33%)
		leucine-rich repeat	514..547	CDD:275380	6/32 (19%)
		leucine-rich repeat	549..575	CDD:275380	10/25 (40%)
		leucine-rich repeat	576..596	CDD:275380	12/19 (63%)
		CARMIL_C	783..1076	CDD:464966	71/351 (20%)