DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRR and crml-1

DIOPT Version :10

Sequence 1:NP_001260788.1 Gene:LRR / 35715 FlyBaseID:FBgn0033212 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_001309450.1 Gene:crml-1 / 172455 WormBaseID:WBGene00010641 Length:1056 Species:Caenorhabditis elegans


Alignment Length:1263 Identity:326/1263 - (25%)
Similarity:528/1263 - (41%) Gaps:298/1263 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 STRSQLTKDLNESVKSILGR---HTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPT-- 61
            ||..:|...:......|||.   .::|:|:  |.:..|.||.|.|:.:.:..|::.|..|..:  
 Worm     6 STIQELCDFVQHKPSQILGNKFFDSRIVVQ--VDVAHKADKYEPRIFIISKFRIFFLMGKTTSSL 68

  Fly    62 KIECHFHYLDIVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLN-------ADVILT 119
            |||..||.|.|      |:.|  :::.:.....:..|        .|...:|       |..:..
 Worm    69 KIEKSFHVLAI------KAIH--VISEEELVIHLDDG--------VHKKKINIKCSIHPAVHLAR 117

  Fly   120 DLASAIKQIFPTVPLKYIIRKIDIQPPERETIFSEEFRPS----DPRNVGPCGGFSAQYACMCDF 180
            .|.||:|..||...: |:...||:.|....|.|     ||    .||   ||..|...||.:|||
 Worm   118 QLLSAVKHYFPDFGV-YLQSSIDVNPSALYTEF-----PSLPTASPR---PCHSFRRTYAALCDF 173

  Fly   181 HGVPYREEVAWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHET 245
            :..|||:||:|||:.||.::..|.|.:.||.||.||||:.||..|:|:.:|.||....:|:|.|.
 Worm   174 YDQPYRDEVSWDVEKIYTANKLRDLKIDDFSHLLPKDLLPIVGVLQYSAYFTGLICDAVRVSSEV 238

  Fly   246 LERILHVLKRSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIED-KGASSLCA 309
            ::.:|.|:::|..|::|.|.:..|..||:..|:.:...|.|..:..:|||.|.|:| ||.:.|.:
 Worm   239 IDVVLSVIRKSQNLKKLQLRSCSLPKDFITLLASAFHNNQNACLEYLDLSRNPIDDKKGFTILSS 303

  Fly   310 LFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMS----HSLTLNQSISNSLTYLDLS 370
            :..::.|               |..:..:.|.|:.|.:|.:.    :.:|..:|....||.|.||
 Worm   304 VLPRLNQ---------------LKYVNFSECQLSDKSINLLCTGLYNGMTSCKSGGMQLTELILS 353

  Fly   371 GNSLKDDITNLHNFLAQPNVLEHLDLASTDITLENL-----FGAL------LRGCATHLAHLNVS 424
            .|.:||||:.:.|.::....|..||.:.|.|.|:.|     ||.|      |.||          
 Worm   354 ANPMKDDISGIINLVSISTSLRVLDFSDTGIHLDKLWNSLKFGGLQIEKLILNGC---------- 408

  Fly   425 HNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNT 489
                |..|..|...:.|::|:...:|.|::.....:|.|.||.:|||||.|:......|||.: |
 Worm   409 ----SLSKKSEGVQTAKEYFSMAVNLSHISFNNTSMPSEYLKAVLLGLASNQQLQPFRLDLDA-T 468

  Fly   490 LGAQGAHVLESCIHGVRVLQSLDISDNNLDAELAPVLTAISKNPSIRTLHLTRS-LTGMKP--KH 551
            .....|.||::||.|:| .::|.:.|||||.||..||.::.....:|.|.:..| :..:|.  |.
 Worm   469 CEKGSASVLDACIGGIR-CETLSLRDNNLDGELQGVLQSLMMVTCLRRLDIGGSNMNQLKKNNKQ 532

  Fly   552 IPPVMDALVNLIQ--KDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARL 614
            :..:...|:::::  .::..|.||.||:.:|...|...||.|.:..:|:.||||||.||:.|||:
 Worm   533 VHVINKVLLDVVKLYSEEGCLEELNLSDCRLGAYLSVLINTLAATTTLKSLDISGNEMGNFGARI 597

  Fly   615 LAKALQINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPV---FDIAPHLKSHPDKTDA 676
            |:||||:|..||::.:|.|.:...|:.|:..:::.||::...|:||   ||....::.  .:|.|
 Worm   598 LSKALQVNVSLRSVSIDNNHIGADGFVDLATSIKMNHTLTHFPYPVHDAFDCMQRVER--PRTVA 660

  Fly   677 VMRKMQELLQRNCNGL-------KRATGQGFRLQHGFMLSSTHQLVDKLVAETQDTISLAKGGSE 734
            .:.::|..|.||...|       |:...:|       :|....:..|::|....|:||       
 Worm   661 ALSQIQNCLYRNRTALGADEANCKKMFAEG-------VLQKMEKANDEVVGSIVDSIS------- 711

  Fly   735 SASAVQRLITDAENCKQLMPKLQEAVRNESHPIEMKMTRVASE-LSYTIKSYLEETMETMMRTGI 798
                       |...:...||:.|.:.......:|:..|:.|| :|.||...|..|.        
 Worm   712 -----------AFGQEPFPPKMIEIIEEFVGKFQMEGGRIISESISRTIGGDLSATS-------- 757

  Fly   799 EQCPKTLGNQIVVQDLRKALAERLVVPEEFLQICLLNNAGSEIMNKVGEIEQSLAAAISDRATDE 863
                            |:|                               ||...|.:::..|::
 Worm   758 ----------------RRA-------------------------------EQLATARLAEVCTEQ 775

  Fly   864 VLEALTRYR-RGMGIAESPSVLLDEPQTPDIVRSRSSHDADGLIIRPGGRGSILPKLGLESPTKL 927
            |....:.:: |.|  .|.....|.:      :....|.||..|     ||.|   .:|..||.  
 Worm   776 VKHVFSEWKWREM--CEHVESELSK------MSIGGSGDACSL-----GRTS---SVGTGSPA-- 822

  Fly   928 EYLNLATPHLPTKRRSLAKKVRPQSVVENLSLGHFPDLLESPSSHRSNSQLSARAAAGAAALVGA 992
                :::|..|  :||.|.. ||:|::.:|:                                  
 Worm   823 ----MSSPFTP--KRSQAGH-RPRSIIGDLT---------------------------------- 846

  Fly   993 ANMTDSIAVDDG---GVDECCDSITELPSASFQLQHLVKGRPKR-------AKTRAPTRPLVTTE 1047
            ::.|.|..|.|.   ||:      .:||.....|.||.|.||::       ..:......::|::
 Worm   847 SSTTSSETVGDSTEQGVN------LDLPPKPSVLSHLQKARPRKRGGASSILNSSLSEDVMMTSK 905

  Fly  1048 CAGGSR-----EIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSLSFVDSP--TMSRDGNGHMTS 1105
            .:||..     ::.|.::...:.....||.:...:.|.|...|.:....|.  |:|...:..::.
 Worm   906 SSGGPENGDLADLIEEVDEVEQEPRKVPTGVRVAMIPDSSLISQVHLRPSAERTLSASSDFSLSP 970

  Fly  1106 EETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRKSPLVKMRTEGGPGSGSAT 1170
            .|.:              ||...::...|.|.::|     ||      |.:..|...|||.....
 Worm   971 REAS--------------SPTTSNSKIMTSSSASD-----SP------PPLPQRNRVGPGGAPPP 1010

  Fly  1171 GAEETSMPSSNLLKATAREDKTRSPSSD 1198
            .......|.|.|:..|:  ..|..|::|
 Worm  1011 LLPPKPEPRSRLIGMTS--PTTPPPTAD 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRNP_001260788.1 Carm_PH 25..130 CDD:436119 28/113 (25%)
RNA1 <198..402 CDD:444072 64/208 (31%)
leucine-rich repeat 289..331 CDD:275381 10/42 (24%)
leucine-rich repeat 332..352 CDD:275381 5/23 (22%)
RNA1 <335..653 CDD:444072 110/337 (33%)
leucine-rich repeat 364..389 CDD:275380 11/24 (46%)
leucine-rich repeat 391..417 CDD:275380 13/36 (36%)
leucine-rich repeat 418..449 CDD:275380 5/30 (17%)
leucine-rich repeat 450..467 CDD:275380 5/16 (31%)
leucine-rich repeat 468..503 CDD:275380 14/34 (41%)
leucine-rich repeat 508..534 CDD:275380 10/25 (40%)
leucine-rich repeat 535..564 CDD:275380 6/31 (19%)
leucine-rich repeat 570..596 CDD:275380 10/25 (40%)
leucine-rich repeat 597..618 CDD:275380 13/20 (65%)
CARMIL_C 797..1111 CDD:464966 57/331 (17%)
crml-1NP_001309450.1 Carm_PH 31..128 CDD:436119 28/114 (25%)
LRR <246..>466 CDD:443914 70/248 (28%)
leucine-rich repeat 252..279 CDD:275380 8/26 (31%)
leucine-rich repeat 282..310 CDD:275380 9/27 (33%)
leucine-rich repeat 311..335 CDD:275380 5/23 (22%)
leucine-rich repeat 347..373 CDD:275380 11/25 (44%)
leucine-rich repeat 374..399 CDD:275380 9/24 (38%)
leucine-rich repeat 400..454 CDD:275380 18/67 (27%)
RNA1 <415..637 CDD:444072 78/223 (35%)
leucine-rich repeat 458..512 CDD:275380 21/55 (38%)
leucine-rich repeat 513..545 CDD:275380 6/31 (19%)
leucine-rich repeat 553..579 CDD:275380 10/25 (40%)
leucine-rich repeat 580..607 CDD:275380 18/26 (69%)
leucine-rich repeat 608..626 CDD:275380 5/17 (29%)

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